Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation
- Authors: Garaev Т.М.1, Yudin I.I.1, Breslav N.V.1, Savochkina Т.Е.1, Krepkaya А.S.1, Grebennikova Т.V.1, Nikiforova S.Е.2, Myshletsov I.I.2, Avdeeva V.V.2, Malinina Е.А.2
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Affiliations:
- National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
- Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 69, No 5 (2024)
- Pages: 736-742
- Section: КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ
- URL: https://kazanmedjournal.ru/0044-457X/article/view/666540
- DOI: https://doi.org/10.31857/S0044457X24050113
- EDN: https://elibrary.ru/YEWODX
- ID: 666540
Cite item
Abstract
This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.
About the authors
Т. М. Garaev
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
I. I. Yudin
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
N. V. Breslav
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
Т. Е. Savochkina
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
А. S. Krepkaya
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
Т. V. Grebennikova
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
S. Е. Nikiforova
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
I. I. Myshletsov
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
V. V. Avdeeva
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
Е. А. Malinina
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow
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