Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains  in vitro  due to zinc(II) complexation

Т. М. Garaev; Гараев Т. М.; I. I. Yudin; Юдин И. И.; N. V. Breslav; Бреслав Н. В.; Т. Е. Savochkina; Савочкина Т. Е.; А. S. Krepkaya; Крепкая А. С.; Т. V. Grebennikova; Гребенникова Т. В.; S. Е. Nikiforova; Никифорова С. Е.; I. I. Myshletsov; Мышлецов И. И.; V. V. Avdeeva; Авдеева В. В.; Е. А. Malinina; Малинина Е. А.

doi:10.31857/S0044457X24050113

Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

作者: Garaev Т.М.¹, Yudin I.I.¹, Breslav N.V.¹, Savochkina Т.Е.¹, Krepkaya А.S.¹, Grebennikova Т.V.¹, Nikiforova S.Е.², Myshletsov I.I.², Avdeeva V.V.², Malinina Е.А.²
隶属关系:
1. National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation
2. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences
期: 卷 69, 编号 5 (2024)
页面: 736-742
栏目: КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ
URL: https://kazanmedjournal.ru/0044-457X/article/view/666540
DOI: https://doi.org/10.31857/S0044457X24050113
EDN: https://elibrary.ru/YEWODX
ID: 666540

如何引用文章

全文:

开放存取

##reader.subscriptionAccessGranted##
受限制的访问

订阅存取

详细
作者简介
参考
补充文件
统计

详细

This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

关键词

influenza A, antiviral activity, water solubility, zinc, L-amino acids, aromatic carboxylic acids

参考

Sarkar A., Mandal K. // Angew. Chem. Int. Ed. Engl. 2021. V. 60. P. 23492. https://doi.org/10.1002/anie.202107481
Davies W.L., Grunnert R.R., Haff R.F. et al. // Science. 1964. V. 44. P. 862.
Togo Y., Hornick R.B., Dawkins A.T. // J. Am. Med. Assoc. 1968. V. 203. P. 1089.
Wendel H.A., Snyder M.T., Pell S. // Clin. Pharmacol. Ther. 1966. V. 7. P. 38.
Okada A., Miura T., Takeuchi H. // Biochemistry. 2001. V. 40. P. 6053.
Avdeeva V.V., Garaev T.M., Malinina E.A. et al. // Russ. J. Inorg. Chem. 2022. V. 67. P. 28. https://doi.org/10.1134/S0036023622010028
Shibnev V.A., Deryabin P.G., Garaev T.M. et al. // Russ. J. Bioorg. Chem. 2017. V. 43. P. 517.
Garaev T.M., Odnovorov A.I., Grebennikova T.V. et al. // Adv. Pharm. Bull. 2021. V. 11. P. 700.
Shibnev V.A., Garaev T.M., Finogenova M.P. et al. // Pharm. Chem. J. 2012. V. 46. P. 36.
Шибнев В.А., Гараев Т.М., Финогенова М.П. и др. Пат. RU 2461544 С1. 2012.
Климочкин Ю.Н., Леонова М.В., Ширяев А.К. Пат. RU 2553991 С1. 2008.
Шибнев В.А., Дерябин П.Г., Бурцева Е.И. Пат. RU 2572102 С1. 2014.
Caetano-Silva M.E., Cilla A., Bertoldo-Pacheco M.T. et al. // J. Food Comp. Anal. 2018. V. 68. P. 95. https://doi.org/10.1016/j.jfca.2017.03.010
Lebedeva N.S., Mal’kova E.A., Pavlycheva N.A. et al. // Russ. J. Coord. Chem. 2004. V. 30. P. 864. https://doi.org/10.1007/s11173-005-0006-5
Zhdanova K.A., Savel’eva I.O., Usanev A.Yu. et al. // Russ. J. Inorg. Chem. 2022. V. 67. P. 1756. https://doi.org/10.1134/S0036023622601209
Dojer B., Golobič A., Babič N. et al. // J. Mol. Struct. 2022. V. 1265. P. 133393. https://doi.org/10.1016/j.molstruc.2022.133393
Chuprin A.S., Dudkin S.V., Vologzhanina A.V. et al. // Russ. J. Inorg. Chem. 2023. V. 68. P. 713. https://doi.org/10.1134/S003602362360065X
Jacob W., Mukherjee R. // Inorg. Chim. Acta. 2006. V. 359. P. 4565. https://doi.org/10.1016/j.ica.2006.07.003
Leite S.M.G., Lima L.M.P., Gama S. et al. // Inorg. Chem. 2016. V. 55. P. 11801. https://doi.org/10.1021/acs.inorgchem.6b01884
Wei Liao, Ziwei Zhu, Chenglian Feng et al. // J. Environ. Sci. 2023. V. 127. P. 495. https://doi.org/10.1016/j.jes.2022.06.002
Gur’eva Y.A., Zalevskaya O.A., Kuchin A.V. // Russ. J. Coord. Chem. 2023. V. 49. P. 631. https://doi.org/10.1134/S1070328423700665
Uvarova M.A., Novikova M.V., Eliseenkova V.A. et al. // Russ. J. Coord. Chem. 2023. V. 49. P. 680. https://doi.org/10.1134/S1070328423600419
Betancourth J.G., Sánchez-Rodríguez N.E., Giraldo-Dávila D. et al. // Russ. J. Inorg. Chem. 2022. V. 67. P. 2200. https://doi.org/10.1134/S0036023622600782
Ivanova I.S., Tsebrikova G.S., Ilyukhin A.B. et al. // Russ. J. Inorg. Chem. 2023. https://doi.org/10.1134/S0036023623601393
Ermakova E.A., Golubeva Y.A., Smirnova K.S. et al. // Russ. J. Coord. Chem. 2023. V. 49. P. 593. https://doi.org/10.1134/S1070328423600158
Garaev T.M., Yudin I.I., Breslav N.V. et al. // Tetrahedron. 2023. V. 151. № 133785.
Garaev T., Breslav N., Grebennikova T. et al. // Proc. 9th Int. Electron. Conf. Med. Chem., 1–30 November 2023, MDPI: Basel, Switzerland. https://doi.org/10.3390/ECMC2023–15805
Garaev T.M., Yudin I.I., Breslav N.V. et al. // Curr. Pharm. Res. 2023 (in press).
Shibnev V.A., Garaev T.M., Finogenova M.P. et al. // Pharm. Chem. J. 2012. V. 46. P. 1.
Бурцева Е.И., Шевченко Е.С., Ленева И.А. и др. // Вопр. вирусологии. 2007. № 2. С. 24.
Лeнeвa И.A., Фaдeeвa Н.И., Фeдякинa И.T. и др. // Хим.-фарм. журн. 1994. № 9. C. 4.
Шибнев В.А., Дерябин П.Г., Бурцева Е.И. Пат. RU 2624906 С1. 2015.

补充文件

附件文件

动作

1. JATS XML

下载

用户名
密码
记住我

忘记您的密码?	注册

用户名
密码
记住我

忘记您的密码?	注册

卷 70, 编号 3 (2025)

Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

全文:

详细

关键词

作者简介

Т. Garaev

I. Yudin

N. Breslav

Т. Savochkina

А. Krepkaya

Т. Grebennikova

S. Nikiforova

I. Myshletsov

V. Avdeeva

Е. Malinina

参考

补充文件