Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

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This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

Sobre autores

Т. Garaev

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

I. Yudin

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

N. Breslav

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

Т. Savochkina

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

А. Krepkaya

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

Т. Grebennikova

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

S. Nikiforova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

I. Myshletsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

V. Avdeeva

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Autor responsável pela correspondência
Email: avdeeva.varvara@mail.ru
Rússia, Moscow

Е. Malinina

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Rússia, Moscow

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