Hemostasis state, adipokine levels and markers of endothelial dysfunction in young patients with components of the metabolic syndrome

Aim. To carry out a comparative assessment of hemostasis, adipokines levels and markers of endothelial dysfunction in young patients with a variety of components of the metabolic syndrome.

Methods. The study included 154 patients aged 18-44 years who were divided into four groups matched for age and sex: the first group - 35 patients with metabolic syndrome, the second group - 25 patients with hypertension without abdominal obesity, the third group - 22 patients with abdominal obesity without hypertension, the fourth group - 72 healthy subjects (control group). We studied the vascular-platelet, coagulation and anticoagulation units of the hemostasis system, the fibrinolytic system, the levels of adipokines and markers of endothelial dysfunction.

Results. Patients with metabolic syndrome showed signs of activation of coagulation together with a slowdown functions of the fibrinolytic system and activation of the anticoagulation system. In young patients with hypertension without abdominal obesity increased were the levels of endothelin, plasminogen activator inhibitor type 1, angiotensin II inhibitor and extrinsic pathway of coagulation. Patients with abdominal obesity without arterial hypertension had no significant change in adipokin levels and markers of endothelial dysfunction compared to control group.

Conclusion. In young patients with a variety of components of the metabolic syndrome revealed were signs of intravascular activation of blood coagulation in conjunction with the imbalance of adipokines levels and endothelial dysfunction.