Interrelation of KIF3A gene polymorphism with predisposition to dermatoses

Aim. To study interrelation of KIF3A gene rs2897442 A/G polymorphism with the dermatoses risk in the Republic of Tatarstan.

Methods. The study involved 95 dermatological patients (67 patients with atopic dermatitis, 16 - psoriasis, 16 - eczema). The control group included 325 people who have not been diagnosed abovementioned skin diseases. KIF3A gene polymorphism was detected by real time polymerase chain reaction. Clinical examination included the atopic dermatitis diagnosis according to Hanifin and Rajka criteria, disease severity determination according to SCORAD scale, skin structural parameters (microrelief, microtopography) study, skin microbial flora characterization.

Results. A statistically significant difference was found out in the KIF3A gene risk allele (G) frequency in patients with skin diseases and concomitant bacterial or fungal infection compared to the control group (57.5 vs 39.7%, p=0.0493). Herewith the presence of unfavourable genotypes (AG+GG) increased the risk of such complications by more than 5 times (OR=5.3, p=0.0145) compared to the normal genotype (AA). Besides, lower (29.2%, p=0.0039) KIF3A gene G allele frequency in the European control group compared with the Russian control group was found.

Conclusion. KIF3A gene rs2897442 A/G polymorphism is associated with complicated forms of dermatoses among Republic of Tatarstan residents; population of the Republic of Tatarstan is genetically more prone to the atopic dermatitis development compared to the European population.