Observation of the Short-term Efficacy of Technetium-99 Conjugated with Methylene Diphosphonate Combined Therapy in the Treatment of Postmenopausal Osteoporosis


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Abstract

Objective:To investigate the short-term efficacy and safety of Yunke (technetium-99 conjugated methylene diphosphonate) combined with pulsed electromagnetic field (PEMF) and Gukang capsule in the treatment of postmenopausal osteoporosis (PMOP).

Methods:A total of 112 patients with PMOP who received treatment in the Department of Nuclear Medicine of the hospital from January 2019 to June 2020 were selected and randomly divided into 4 groups of 28 patients each. Group A received Yunke and PEMFs, group B received Gukang capsules and PEMFs, group C received Yunke and Gukang capsules and PEMFs, and group D received PEMFs. All groups were given adequate amounts of calcium and active vitamin D. Intervention 2 sessions of 3 months each. Outcome measures were bone mineral density (BMD) and pain improvement.

Results:Compared with 1 course of treatment, the symptoms of bone pain were relieved more significantly after 2 courses of treatment in group A (50.0% vs. 64.3%), group B (46.4% vs 64.3%), group C (78.6% vs 92.9%) and group D (21.4% vs 28.6%) (p < 0.05). After 2 courses of treatment, bone pain symptoms were less relieved in group A (96.4% vs. 64.3%), group B (96.4% vs 64.3%), and group D (96.4% vs 28.6%) compared with group C (p < 0.05). Compared with group C, BMD values of L4 vertebrae and femoral neck were significantly decreased in groups A, B, and D (p < 0.05). Compared with those before treatment, BMD of L4 vertebrae and femoral neck increased significantly in groups A, B, C, and D after 2 courses of treatment (p < 0.05).

Conclusion:Yunke combined therapy can effectively relieve the pain symptoms, increase BMD, and reduce the risk of fracture in patients with PMOP in a short period, which is an effective method for the treatment of PMOP.

About the authors

Wen Sun

Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical University

Email: info@benthamscience.net

Quan Xie

Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical College

Email: info@benthamscience.net

Juan-Juan Yan

Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical College

Email: info@benthamscience.net

Ying Huang

Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical College

Email: info@benthamscience.net

Ying Zhou

Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical College

Email: info@benthamscience.net

Huan Xiao

Department of Nuclear Medicine, The First Affiliated Hospital of Hainan Medical Universit

Author for correspondence.
Email: info@benthamscience.net

Chao-Qun Wang

Department of Nuclear Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University

Author for correspondence.
Email: info@benthamscience.net

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