Searching for Essential Genes and Targeted Drugs Common to Breast Cancer and Osteoarthritis


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Аннотация

Background:It is documented that osteoarthritis can promote the progression of breast cancer (BC).

Objective:This study aims to search for the essential genes associated with breast cancer (BC) and osteoarthritis (OA), explore the relationship between epithelial-mesenchymal transition (EMT)- related genes and the two diseases, and identify the candidate drugs.

Methods:The genes related to both BC and OA were determined by text mining. Protein-protein Interaction (PPI) analysis was carried out, and as a result, the exported genes were found to be related to EMT. PPI and the correlation of mRNA of these genes were also analyzed. Different kinds of enrichment analyses were performed on these genes. A prognostic analysis was performed on these genes for examining their expression levels at different pathological stages, in different tissues, and in different immune cells. Drug–gene interaction database was employed for potential drug discovery.

Results:A total number of 1422 genes were identified as common to BC and OA and 58 genes were found to be related to EMT. We found that HDAC2 and TGFBR1 were significantly poor in overall survival. High expression of HDAC2 plays a vital role in the increase of pathological stages. Four immune cells might play a role in this process. Fifty-seven drugs were identified that could potentially have therapeutic effects.

Conclusion:EMT may be one of the mechanisms by which OA affects BC. Using the drugs can have potential therapeutic effects, which may benefit patients with both diseases and broaden the indications for drug use.

Об авторах

Liantao Guo

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University

Email: info@benthamscience.net

Deguang Kong

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University

Email: info@benthamscience.net

Jianhua Liu

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University

Email: info@benthamscience.net

Lan Luo

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University

Email: info@benthamscience.net

Weijie Zheng

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University

Email: info@benthamscience.net

Chuang Chen

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University

Автор, ответственный за переписку.
Email: info@benthamscience.net

Shengrong Sun

Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University

Автор, ответственный за переписку.
Email: info@benthamscience.net

Список литературы

  1. Henley, S.J.; Ward, E.M.; Scott, S.; Ma, J.; Anderson, R.N.; Firth, A.U.; Thomas, C.C.; Islami, F.; Weir, H.K.; Lewis, D.R.; Sherman, R.L.; Wu, M.; Benard, V.B.; Richardson, L.C.; Jemal, A.; Cronin, K.; Kohler, B.A. Annual report to the nation on the status of cancer, part I: National cancer statistics. Cancer, 2020, 126(10), 2225-2249. doi: 10.1002/cncr.32802 PMID: 32162336
  2. Siegel, R.L.; Miller, K.D.; Fuchs, H.E.; Jemal, A. Cancer Statistics, 2021. CA Cancer J. Clin., 2021, 71(1), 7-33. doi: 10.3322/caac.21654 PMID: 33433946
  3. Arnedos, M.; Vicier, C.; Loi, S.; Lefebvre, C.; Michiels, S.; Bonnefoi, H.; Andre, F. Precision medicine for metastatic breast cancer-limitations and solutions. Nat. Rev. Clin. Oncol., 2015, 12(12), 693-704. doi: 10.1038/nrclinonc.2015.123 PMID: 26196250
  4. Koboldt, D.C.; Fulton, R.S.; McLellan, M.D.; Schmidt, H.; Kalicki-Veizer, J.; McMichael, J.F.; Fulton, L.L.; Dooling, D.J.; Ding, L.; Mardis, E.R.; Wilson, R.K.; Ally, A.; Balasundaram, M.; Butterfield, Y.S.N.; Carlsen, R.; Carter, C.; Chu, A.; Chuah, E.; Chun, H.J.E.; Coope, R.J.N.; Dhalla, N.; Guin, R.; Hirst, C.; Hirst, M.; Holt, R.A.; Lee, D.; Li, H.Y.I.; Mayo, M.; Moore, R.A.; Mungall, A.J.; Pleasance, E.; Robertson, A.G.; Schein, J.E.; Shafiei, A.; Sipahimalani, P.; Slobodan, J.R.; Stoll, D.; Tam, A.; Thiessen, N.; Varhol, R.J.; Wye, N.; Zeng, T.; Zhao, Y.J.; Birol, I.; Jones, S.J.M.; Marra, M.A.; Cherniack, A.D.; Saksena, G.; Onofrio, R.C.; Pho, N.H.; Carter, S.L.; Schumacher, S.E.; Tabak, B.; Hernandez, B.; Gentry, J.; Nguyen, H.; Crenshaw, A.; Ardlie, K.; Beroukhim, R.; Winckler, W.; Getz, G.; Gabriel, S.B.; Meyerson, M.; Chin, L.; Park, P.J.; Kucherlapati, R.; Hoadley, K.A.; Auman, J.T.; Fan, C.; Turman, Y.J.; Shi, Y.; Li, L.; Topal, M.D.; He, X.P.; Chao, H.H.; Prat, A.; Silva, G.O.; Iglesia, M.D.; Zhao, W.; Usary, J.; Berg, J.S.; Adams, M.; Booker, J.; Wu, J.Y.; Gulabani, A.; Bodenheimer, T.; Hoyle, A.P.; Simons, J.V.; Soloway, M.G.; Mose, L.E.; Jefferys, S.R.; Balu, S.; Parker, J.S.; Hayes, D.N.; Perou, C.M.; Malik, S.; Mahurkar, S.; Shen, H.; Weisenberger, D.J.; Triche, T.; Lai, P.H.; Bootwalla, M.S.; Maglinte, D.T.; Berman, B.P.; Van den Berg, D.J.; Baylin, S.B.; Laird, P.W.; Creighton, C.J.; Donehower, L.A.; Getz, G.; Noble, M.; Voet, D.; Saksena, G.; Gehlenborg, N.; DiCara, D.; Zhang, J.H.; Zhang, H.L.; Wu, C.J.; Liu, S.Y.; Lawrence, M.S.; Zou, L.H.; Sivachenko, A.; Lin, P.; Stojanov, P.; Jing, R.; Cho, J.; Sinha, R.; Park, R.W.; Nazaire, M.D.; Robinson, J.; Thorvaldsdottir, H.; Mesirov, J.; Park, P.J.; Chin, L.; Reynolds, S.; Kreisberg, R.B.; Bernard, B.; Bressler, R.; Erkkila, T.; Lin, J.; Thorsson, V.; Zhang, W.; Shmulevich, I.; Ciriello, G.; Weinhold, N.; Schultz, N.; Gao, J.J.; Cerami, E.; Gross, B.; Jacobsen, A.; Sinha, R.; Aksoy, B.A.; Antipin, Y.; Reva, B.; Shen, R.L.; Taylor, B.S.; Ladanyi, M.; Sander, C.; Anur, P.; Spellman, P.T.; Lu, Y.L.; Liu, W.B.; Verhaak, R.R.G.; Mills, G.B.; Akbani, R.; Zhang, N.X.; Broom, B.M.; Casasent, T.D.; Wakefield, C.; Unruh, A.K.; Baggerly, K.; Coombes, K.; Weinstein, J.N.; Haussler, D.; Benz, C.C.; Stuart, J.M.; Benz, S.C.; Zhu, J.C.; Szeto, C.C.; Scott, G.K.; Yau, C.; Paul, E.O.; Carlin, D.; Wong, C.; Sokolov, A.; Thusberg, J.; Mooney, S.; Ng, S.; Goldstein, T.C.; Ellrott, K.; Grifford, M.; Wilks, C.; Ma, S.; Craft, B.; Yan, C.H.; Hu, Y.; Meerzaman, D.; Gastier-Foster, J.M.; Bowen, J.; Ramirez, N.C.; Black, A.D.; Pyatt, R.E.; White, P.; Zmuda, E.J.; Frick, J.; Lichtenberg, T.; Brookens, R.; George, M.M.; Gerken, M.A.; Harper, H.A.; Leraas, K.M.; Wise, L.J.; Tabler, T.R.; McAllister, C.; Barr, T.; Hart-Kothari, M.; Tarvin, K.; Saller, C.; Sandusky, G.; Mitchell, C.; Iacocca, M.V.; Brown, J.; Rabeno, B.; Czerwinski, C.; Petrelli, N.; Dolzhansky, O.; Abramov, M.; Voronina, O.; Potapova, O.; Marks, J.R.; Suchorska, W.M.; Murawa, D.; Kycler, W.; Ibbs, M.; Korski, K.; Spychala, A.; Murawa, P.; Brzezinski, J.J.; Perz, H.; Lazniak, R.; Teresiak, M.; Tatka, H.; Leporowska, E.; Bogusz-Czerniewicz, M.; Malicki, J.; Mackiewicz, A.; Wiznerowicz, M.; Le, X.V.; Kohl, B.; Tien, N.V.; Thorp, R.; Bang, N.V.; Sussman, H.; Phu, B.D.; Hajek, R.; Hung, N.P.; Tran, V.T.P.; Thang, H.Q.; Khan, K.Z.; Penny, R.; Mallery, D.; Curley, E.; Shelton, C.; Yena, P.; Ingle, J.N.; Couch, F.J.; Lingle, W.L.; King, T.A.; Gonzalez-Angulo, A.M.; Mills, G.B.; Dyer, M.D.; Liu, S.Y.; Meng, X.L.; Patangan, M.; Waldman, F.; Stoppler, H.; Rathmell, W.K.; Thorne, L.; Huang, M.; Boice, L.; Hill, A.; Morrison, C.; Gaudioso, C.; Bshara, W.; Daily, K.; Egea, S.C.; Pegram, M.D.; Gomez-Fernandez, C.; Dhir, R.; Bhargava, R.; Brufsky, A.; Shriver, C.D.; Hooke, J.A.; Campbell, J.L.; Mural, R.J.; Hu, H.; Somiari, S.; Larson, C.; Deyarmin, B.; Kvecher, L.; Kovatich, A.J.; Ellis, M.J.; King, T.A.; Hu, H.; Couch, F.J.; Mural, R.J.; Stricker, T.; White, K.; Olopade, O.; Ingle, J.N.; Luo, C.Q.; Chen, Y.Q.; Marks, J.R.; Waldman, F.; Wiznerowicz, M.; Bose, R.; Chang, L.W.; Beck, A.H.; Gonzalez-Angulo, A.M.; Pihl, T.; Jensen, M.; Sfeir, R.; Kahn, A.; Chu, A.; Kothiyal, P.; Wang, Z.N.; Snyder, E.; Pontius, J.; Ayala, B.; Backus, M.; Walton, J.; Baboud, J.; Berton, D.; Nicholls, M.; Srinivasan, D.; Raman, R.; Girshik, S.; Kigonya, P.; Alonso, S.; Sanbhadti, R.; Barletta, S.; Pot, D.; Sheth, M.; Demchok, J.A.; Shaw, K.R.M.; Yang, L.M.; Eley, G.; Ferguson, M.L.; Tarnuzzer, R.W.; Zhang, J.S.; Dillon, L.A.L.; Buetow, K.; Fielding, P.; Ozenberger, B.A.; Guyer, M.S.; Sofia, H.J.; Palchik, J.D.; Canc Genome Atlas, N. Comprehensive molecular portraits of human breast tumours. Nature, 2012, 490(7418), 61-70. doi: 10.1038/nature11412 PMID: 23000897
  5. Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 2021, 71(3), 209-249. doi: 10.3322/caac.21660 PMID: 33538338
  6. Allemani, C.; Matsuda, T.; Di Carlo, V.; Harewood, R.; Matz, M. Nikšić, M.; Bonaventure, A.; Valkov, M.; Johnson, C.J.; Estève, J.; Ogunbiyi, O.J.; Azevedo e Silva, G.; Chen, W.Q.; Eser, S.; Engholm, G.; Stiller, C.A.; Monnereau, A.; Woods, R.R.; Visser, O.; Lim, G.H.; Aitken, J.; Weir, H.K.; Coleman, M.P.; Bouzbid, S.; Hamdi-Chérif, M.; Zaidi, Z.; Meguenni, K.; Regagba, D.; Bayo, S.; Cheick Bougadari, T.; Manraj, S.S.; Bendahhou, K.; Fabowale, A.; Bradshaw, D.; Somdyala, N.I.M.; Kumcher, I.; Moreno, F.; Calabrano, G.H.; Espinola, S.B.; Carballo Quintero, B.; Fita, R.; Diumenjo, M.C.; Laspada, W.D.; Ibañez, S.G.; Lima, C.A.; De Souza, P.C.F.; Del Pino, K.; Laporte, C.; Curado, M.P.; de Oliveira, J.C.; Veneziano, C.L.A.; Veneziano, D.B.; Latorre, M.R.D.O.; Tanaka, L.F.; Rebelo, M.S.; Santos, M.O.; Galaz, J.C.; Aparicio Aravena, M.; Sanhueza Monsalve, J.; Herrmann, D.A.; Vargas, S.; Herrera, V.M.; Uribe, C.J.; Bravo, L.E.; Garcia, L.S.; Arias-Ortiz, N.E.; Morantes, D.; Jurado, D.M.; Yépez Chamorro, M.C.; Delgado, S.; Ramirez, M.; Galán Alvarez, Y.H.; Torres, P.; Martínez-Reyes, F.; Jaramillo, L.; Quinto, R.; Castillo, J.; Mendoza, M.; Cueva, P.; Yépez, J.G.; Bhakkan, B.; Deloumeaux, J.; Joachim, C.; Macni, J.; Carrillo, R.; Shalkow, K.J.; Rivera, G.R.; Poquioma, E.; Tortolero-Luna, G.; Zavala, D.; Alonso, R.; Barrios, E.; Eckstrand, A.; Nikiforuk, C.; Noonan, G.; Turner, D.; Kumar, E.; Zhang, B.; McCrate, F.R.; Ryan, S.; MacIntyre, M.; Saint-Jacques, N.; Nishri, D.E.; McClure, C.A.; Vriends, K.A.; Kozie, S.; Stuart-Panko, H.; Freeman, T.; George, J.T.; Brockhouse, J.T.; O’Brien, D.K.; Holt, A.; Almon, L.; Kwong, S.; Morris, C.; Rycroft, R.; Mueller, L.; Phillips, C.E.; Brown, H.; Cromartie, B.; Schwartz, A.G.; Vigneau, F.; Levin, G.M.; Wohler, B.; Bayakly, R.; Ward, K.C.; Gomez, S.L.; McKinley, M.; Cress, R.; Green, M.D.; Miyagi, K.; Ruppert, L.P.; Lynch, C.F.; Huang, B.; Tucker, T.C.; Deapen, D.; Liu, L.; Hsieh, M.C.; Wu, X.C.; Schwenn, M.; Gershman, S.T.; Knowlton, R.C.; Alverson, G.; Copeland, G.E.; Bushhouse, S.; Rogers, D.B.; Jackson-Thompson, J.; Lemons, D.; Zimmerman, H.J.; Hood, M.; Roberts-Johnson, J.; Rees, J.R.; Riddle, B.; Pawlish, K.S.; Stroup, A.; Key, C.; Wiggins, C.; Kahn, A.R.; Schymura, M.J.; Radhakrishnan, S.; Rao, C.; Giljahn, L.K.; Slocumb, R.M.; Espinoza, R.E.; Khan, F.; Aird, K.G.; Beran, T.; Rubertone, J.J.; Slack, S.J.; Garcia, L.; Rousseau, D.L.; Janes, T.A.; Schwartz, S.M.; Bolick, S.W.; Hurley, D.M.; Whiteside, M.A.; Miller-Gianturco, P.; Williams, M.A.; Herget, K.; Sweeney, C.; Johnson, A.T.; Keitheri Cheteri, M.B.; Migliore Santiago, P.; Blankenship, S.E.; Farley, S.; Borchers, R.; Malicki, R.; Espinoza, J.R.; Grandpre, J.; Wilson, R.; Edwards, B.K.; Mariotto, A.; Lei, Y.; Wang, N.; Chen, J.S.; Zhou, Y.; He, Y.T.; Song, G.H.; Gu, X.P.; Mei, D.; Mu, H.J.; Ge, H.M.; Wu, T.H.; Li, Y.Y.; Zhao, D.L.; Jin, F.; Zhang, J.H.; Zhu, F.D.; Junhua, Q.; Yang, Y.L.; Jiang, C.X.; Biao, W.; Wang, J.; Li, Q.L.; Yi, H.; Zhou, X.; Dong, J.; Li, W.; Fu, F.X.; Liu, S.Z.; Chen, J.G.; Zhu, J.; Li, Y.H.; Lu, Y.Q.; Fan, M.; Huang, S.Q.; Guo, G.P.; Zhaolai, H.; Wei, K.; Zeng, H.; Demetriou, A.V.; Mang, W.K.; Ngan, K.C.; Kataki, A.C.; Krishnatreya, M.; Jayalekshmi, P.A.; Sebastian, P.; Nandakumar, A.; Malekzadeh, R.; Roshandel, G.; Keinan-Boker, L.; Silverman, B.G.; Ito, H.; Nakagawa, H.; Sato, M.; Tobori, F.; Nakata, I.; Teramoto, N.; Hattori, M.; Kaizaki, Y.; Moki, F.; Sugiyama, H.; Utada, M.; Nishimura, M.; Yoshida, K.; Kurosawa, K.; Nemoto, Y.; Narimatsu, H.; Sakaguchi, M.; Kanemura, S.; Naito, M.; Narisawa, R.; Miyashiro, I.; Nakata, K.; Sato, S.; Yoshii, M.; Oki, I.; Fukushima, N.; Shibata, A.; Iwasa, K.; Ono, C.; Nimri, O.; Jung, K.W.; Won, Y.J.; Alawadhi, E.; Elbasmi, A.; Ab Manan, A.; Adam, F.; Sanjaajmats, E.; Tudev, U.; Ochir, C.; Al Khater, A.M.; El Mistiri, M.M.; Teo, Y.Y.; Chiang, C.J.; Lee, W.C.; Buasom, R.; Sangrajrang, S.; Kamsa-ard, S.; Wiangnon, S.; Daoprasert, K.; Pongnikorn, D.; Leklob, A.; Sangkitipaiboon, S.; Geater, S.L.; Sriplung, H.; Ceylan, O.; Kög, I.; Dirican, O.; Köse, T.; Gurbuz, T.; Karaşahin, F.E.; Turhan, D.; Aktaş U.; Halat, Y.; Yakut, C.I.; Altinisik, M.; Cavusoglu, Y.; Türkköylü, A.; Üçüncü, N.; Hackl, M.; Zborovskaya, A.A.; Aleinikova, O.V.; Henau, K.; Van Eycken, L.; Valerianova, Z.; Yordanova, M.R.; Šekerija, M.; Dušek, L.; Zvolský, M.; Storm, H.; Innos, K.; Mägi, M.; Malila, N.; Seppä, K.; Jégu, J.; Velten, M.; Cornet, E.; Troussard, X.; Bouvier, A.M.; Guizard, A.V.; Bouvier, V.; Launoy, G.; Arveux, P.; Maynadié, M.; Mounier, M.; Woronoff, A.S.; Daoulas, M.; Robaszkiewicz, M.; Clavel, J.; Goujon, S.; Lacour, B.; Baldi, I.; Pouchieu, C.; Amadeo, B.; Coureau, G.; Orazio, S.; Preux, P.M.; Rharbaoui, F.; Marrer, E.; Trétarre, B.; Colonna, M.; Delafosse, P.; Ligier, K.; Plouvier, S.; Cowppli-Bony, A.; Molinié, F.; Bara, S.; Ganry, O.; Lapôtre-Ledoux, B.; Grosclaude, P.; Bossard, N.; Uhry, Z.; Bray, F.; Piñeros, M.; Stabenow, R.; Wilsdorf-Köhler, H.; Eberle, A.; Luttmann, S.; Löhden, I.; Nennecke, A.L.; Kieschke, J.; Sirri, E.; Emrich, K.; Zeissig, S.R.; Holleczek, B.; Eisemann, N.; Katalinic, A.; Asquez, R.A.; Kumar, V.; Petridou, E.; Ólafsdóttir, E.J.; Tryggvadóttir, L.; Clough-Gorr, K.; Walsh, P.M.; Sundseth, H.; Mazzoleni, G.; Vittadello, F.; Coviello, E.; Cuccaro, F.; Galasso, R.; Sampietro, G.; Giacomin, A.; Magoni, M.; Ardizzone, A.; D’Argenzio, A.; Castaing, M.; Grosso, G.; Lavecchia, A.M.; Sutera Sardo, A.; Gola, G.; Gatti, L.; Ricci, P.; Ferretti, S.; Serraino, D.; Zucchetto, A.; Celesia, M.V.; Filiberti, R.A.; Pannozzo, F.; Melcarne, A.; Quarta, F.; Russo, A.G.; Carrozzi, G.; Cirilli, C.; Cavalieri d’Oro, L.; Rognoni, M.; Fusco, M.; Vitale, M.F.; Usala, M.; Cusimano, R.; Mazzucco, W.; Michiara, M.; Sgargi, P.; Boschetti, L.; Borciani, E.; Seghini, P.; Maule, M.M.; Merletti, F.; Tumino, R.; Mancuso, P.; Vicentini, M.; Cassetti, T.; Sassatelli, R.; Falcini, F.; Giorgetti, S.; Caiazzo, A.L.; Cavallo, R.; Cesaraccio, R.; Pirino, D.R.; Contrino, M.L.; Tisano, F.; Fanetti, A.C.; Maspero, S.; Carone, S.; Mincuzzi, A.; Candela, G.; Scuderi, T.; Gentilini, M.A.; Piffer, S.; Rosso, S.; Barchielli, A.; Caldarella, A.; Bianconi, F.; Stracci, F.; Contiero, P.; Tagliabue, G.; Rugge, M.; Zorzi, M.; Beggiato, S.; Brustolin, A.; Berrino, F.; Gatta, G.; Sant, M.; Buzzoni, C.; Mangone, L.; Capocaccia, R.; De Angelis, R.; Zanetti, R.; Maurina, A.; Pildava, S.; Lipunova, N.; Vincerževskiené, I.; Agius, D.; Calleja, N.; Siesling, S.; Larønningen, S.; Møller, B.; Dyzmann-Sroka, A.; Trojanowski, M.; Góźdź, S.Mężyk, R.; Mierzwa, T.; Molong, L.; Rachtan, J.; Szewczyk, S.; BBłaszczyk, J.; Kępska, K.; Kościańska, B.; Tarocińska, K.; Zwierko, M.; Drosik, K.; Maksimowicz, K.M.; Purwin-Porowska, E.; Reca, E.; Wójcik-Tomaszewska, J.; Tukiendorf, A.; Grądalska-Lampart, M.; Radziszewska, A.U.; Gos, A.; Talerczyk, M.; Wyborska, M.; Didkowska, J.A.; Wojciechowska, U.; Bielska-Lasota, M.; Forjaz de Lacerda, G.; Rego, R.A.; Bastos, J.; Silva, M.A.; Antunes, L.; Laranja Pontes, J.; Mayer-da-Silva, A.; Miranda, A.; Blaga, L.M.; Coza, D.; Gusenkova, L.; Lazarevich, O.; Prudnikova, O.; Vjushkov, D.M.; Egorova, A.G.; Orlov, A.E.; Kudyakov, L.A.; Pikalova, L.V.; Adamcik, J.; Safaei Diba, C.; Primic-Žakelj, M.; Zadnik, V.; Larrañaga, N.; Lopez de Munain, A.; Herrera, A.A.; Redondas, R.; Marcos-Gragera, R.; Vilardell Gil, M.L.; Molina, E.; Sánchez Perez, M.J.; Franch Sureda, P.; Ramos Montserrat, M.; Chirlaque, M.D.; Navarro, C.; Ardanaz, E.E.; Guevara, M.M.; Fernández-Delgado, R.; Peris-Bonet, R.; Carulla, M.; Galceran, J.; Alberich, C.; Vicente-Raneda, M.; Khan, S.; Pettersson, D.; Dickman, P.; Avelina, I.; Staehelin, K.; Camey, B.; Bouchardy, C.; Schaffar, R.; Frick, H.; Herrmann, C.; Bulliard, J.L.; Maspoli-Conconi, M.; Kuehni, C.E.; Redmond, S.M.; Bordoni, A.; Ortelli, L.; Chiolero, A.; Konzelmann, I.; Matthes, K.L.; Rohrmann, S.; Broggio, J.; Rashbass, J.; Fitzpatrick, D.; Gavin, A.; Clark, D.I.; Deas, A.J.; Huws, D.W.; White, C.; Montel, L.; Rachet, B.; Turculet, A.D.; Stephens, R.; Chalker, E.; Phung, H.; Walton, R.; You, H.; Guthridge, S.; Johnson, F.; Gordon, P.; D’Onise, K.; Priest, K.; Stokes, B.C.; Venn, A.; Farrugia, H.; Thursfield, V.; Dowling, J.; Currow, D.; Hendrix, J.; Lewis, C. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet, 2018, 391(10125), 1023-1075. doi: 10.1016/S0140-6736(17)33326-3 PMID: 29395269
  7. Tulotta, C.; Ottewell, P. The role of IL-1B in breast cancer bone metastasis. Endocr. Relat. Cancer, 2018, 25(7), R421-R434. doi: 10.1530/ERC-17-0309 PMID: 29760166
  8. Chaffer, C.L.; San Juan, B.P.; Lim, E.; Weinberg, R.A. EMT, cell plasticity and metastasis. Cancer Metastasis Rev., 2016, 35(4), 645-654. doi: 10.1007/s10555-016-9648-7 PMID: 27878502
  9. Karamanou, K.; Franchi, M.; Vynios, D.; Brézillon, S. Epithelial-to-mesenchymal transition and invadopodia markers in breast cancer: Lumican a key regulator. Semin. Cancer Biol., 2020, 62, 125-133. doi: 10.1016/j.semcancer.2019.08.003 PMID: 31401293
  10. Kalluri, R.; Weinberg, R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest., 2009, 119(6), 1420-1428. doi: 10.1172/JCI39104 PMID: 19487818
  11. Kong, D.; Zhou, H.; Neelakantan, D.; Hughes, C.J.; Hsu, J.Y.; Srinivasan, R.R.; Lewis, M.T.; Ford, H.L. VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk. Oncogene, 2021, 40(5), 964-979. doi: 10.1038/s41388-020-01539-x PMID: 33299122
  12. Gupta, G.P. Massagué, J. Cancer metastasis: Building a framework. Cell, 2006, 127(4), 679-695. doi: 10.1016/j.cell.2006.11.001 PMID: 17110329
  13. Davis, F.M.; Azimi, I.; Faville, R.A.; Peters, A.A.; Jalink, K.; Putney, J.W., Jr; Goodhill, G.J.; Thompson, E.W.; Roberts-Thomson, S.J.; Monteith, G.R. Induction of epithelial–mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene, 2014, 33(18), 2307-2316. doi: 10.1038/onc.2013.187 PMID: 23686305
  14. Zeng, K.; He, B.; Yang, B.B.; Xu, T.; Chen, X.; Xu, M.; Liu, X.; Sun, H.; Pan, Y.; Wang, S. The pro-metastasis effect of circANKS1B in breast cancer. Mol. Cancer, 2018, 17(1), 160. doi: 10.1186/s12943-018-0914-x PMID: 30454010
  15. Samuel, S.M.; Varghese, E.; Varghese, S.; Büsselberg, D. Challenges and perspectives in the treatment of diabetes associated breast cancer. Cancer Treat. Rev., 2018, 70, 98-111. doi: 10.1016/j.ctrv.2018.08.004 PMID: 30130687
  16. Sin, A.; Tang, W.; Wen, C.Y.; Chung, S.K.; Chiu, K.Y. The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis. Osteoarthr. Cartil., 2015, 23(4), 516-524. doi: 10.1016/j.joca.2014.11.002 PMID: 25463446
  17. Astephen Wilson, J.L.; Kobsar, D. Osteoarthritis year in review 2020: Mechanics. Osteoarthr. Cartil., 2021, 29(2), 161-169. doi: 10.1016/j.joca.2020.12.009 PMID: 33421562
  18. Jacob, L.; Kostev, K. Osteoarthritis and the incidence of fracture in the United Kingdom: A retrospective cohort study of 258,696 patients. Osteoarthr. Cartil., 2021, 29(2), 215-221. doi: 10.1016/j.joca.2020.12.006 PMID: 33359250
  19. Glyn-Jones, S.; Palmer, A.J.R.; Agricola, R.; Price, A.J.; Vincent, T.L.; Weinans, H.; Carr, A.J. Osteoarthritis. Lancet, 2015, 386(9991), 376-387. doi: 10.1016/S0140-6736(14)60802-3 PMID: 25748615
  20. Sharma, T.; Radosevich, J.A.; Pachori, G.; Mandal, C.C. A molecular view of pathological microcalcification in breast cancer. J. Mammary Gland Biol. Neoplasia, 2016, 21(1-2), 25-40. doi: 10.1007/s10911-015-9349-9 PMID: 26769216
  21. Quigley, D.A.; Tahiri, A.; Lüders, T.; Riis, M.H.; Balmain, A.; Børresen-Dale, A.L.; Bukholm, I.; Kristensen, V. Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue. OncoImmunology, 2017, 6(11), e1356142. doi: 10.1080/2162402X.2017.1356142 PMID: 29147603
  22. Clemenceau, A.; Michou, L.; Diorio, C.; Durocher, F. Breast cancer and microcalcifications: An osteoimmunological disorder? Int. J. Mol. Sci., 2020, 21(22), 8613. doi: 10.3390/ijms21228613 PMID: 33203195
  23. Wagner, P.; Olsson, H.; Lidgren, L.; Robertsson, O.; Ranstam, J. Increased cancer risks among arthroplasty patients: 30year follow-up of the Swedish knee arthroplasty register. Eur. J. Cancer, 2011, 47(7), 1061-1071. doi: 10.1016/j.ejca.2010.11.023 PMID: 21227681
  24. Ward, M.M.; Alehashemi, S. Risks of solid cancers in elderly persons with osteoarthritis or ankylosing spondylitis. Rheumatology, 2020, 59(12), 3817-3825. doi: 10.1093/rheumatology/keaa166 PMID: 32442295
  25. Bonfiglio, R.; Scimeca, M.; Toschi, N.; Pistolese, C.A.; Giannini, E.; Antonacci, C.; Ciuffa, S.; Tancredi, V.; Tarantino, U.; Albonici, L.; Bonanno, E. Radiological, histological and chemical analysis of breast microcalcifications: Diagnostic value and biological significance. J. Mammary Gland Biol. Neoplasia, 2018, 23(1-2), 89-99. doi: 10.1007/s10911-018-9396-0 PMID: 29744755
  26. Gnant, M.; Pfeiler, G.; Steger, G.G.; Egle, D.; Greil, R.; Fitzal, F.; Wette, V.; Balic, M.; Haslbauer, F.; Melbinger-Zeinitzer, E.; Bjelic-Radisic, V.; Jakesz, R.; Marth, C.; Sevelda, P.; Mlineritsch, B.; Exner, R.; Fesl, C.; Frantal, S.; Singer, C.F. Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol., 2019, 20(3), 339-351. doi: 10.1016/S1470-2045(18)30862-3 PMID: 30795951
  27. Vetter, M.; Landin, J.; Szczerba, B.M.; Castro-Giner, F.; Gkountela, S.; Donato, C.; Krol, I.; Scherrer, R.; Balmelli, C.; Malinovska, A.; Zippelius, A.; Kurzeder, C.; Heinzelmann-Schwarz, V.; Weber, W.P.; Rochlitz, C.; Aceto, N. Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer. Breast Cancer Res., 2018, 20(1), 141. doi: 10.1186/s13058-018-1067-y PMID: 30458879
  28. Holen, I.; Lefley, D.V.; Francis, S.E.; Rennicks, S.; Bradbury, S.; Coleman, R.E.; Ottewell, P. IL-1 drives breast cancer growth and bone metastasis in vivo. Oncotarget, 2016, 7(46), 75571-75584. doi: 10.18632/oncotarget.12289 PMID: 27765923
  29. Wu, T.C.; Xu, K.; Martinek, J.; Young, R.R.; Banchereau, R.; George, J.; Turner, J.; Kim, K.I.; Zurawski, S.; Wang, X.; Blankenship, D.; Brookes, H.M.; Marches, F.; Obermoser, G.; Lavecchio, E.; Levin, M.K.; Bae, S.; Chung, C.H.; Smith, J.L.; Cepika, A.M.; Oxley, K.L.; Snipes, G.J.; Banchereau, J.; Pascual, V.; O’Shaughnessy, J.; Palucka, A.K. IL1 receptor antagonist controls transcriptional signature of inflammation in patients with metastatic breast cancer. Cancer Res., 2018, 78(18), 5243-5258. doi: 10.1158/0008-5472.CAN-18-0413 PMID: 30012670
  30. Tulotta, C.; Lefley, D.V.; Freeman, K.; Gregory, W.M.; Hanby, A.M.; Heath, P.R.; Nutter, F.; Wilkinson, J.M.; Spicer-Hadlington, A.R.; Liu, X.; Bradbury, S.M.J.; Hambley, L.; Cookson, V.; Allocca, G.; Kruithof de Julio, M.; Coleman, R.E.; Brown, J.E.; Holen, I.; Ottewell, P.D. Endogenous production of IL1B by breast cancer cells drives metastasis and colonization of the bone microenvironment. Clin. Cancer Res., 2019, 25(9), 2769-2782. doi: 10.1158/1078-0432.CCR-18-2202 PMID: 30670488
  31. Rodriguez-Barrueco, R.; Yu, J.; Saucedo-Cuevas, L.P.; Olivan, M.; Llobet-Navas, D.; Putcha, P.; Castro, V.; Murga-Penas, E.M.; Collazo-Lorduy, A.; Castillo-Martin, M.; Alvarez, M.; Cordon-Cardo, C.; Kalinsky, K.; Maurer, M.; Califano, A.; Silva, J.M. Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR − /HER2 + breast cancers. Genes Dev., 2015, 29(15), 1631-1648. doi: 10.1101/gad.262642.115 PMID: 26227964
  32. Alraouji, N.N.; Al-Mohanna, F.H.; Ghebeh, H.; Arafah, M.; Almeer, R.; Al-Tweigeri, T.; Aboussekhra, A. Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triplenegative breast cancer. Mol. Carcinog., 2020, 59(9), 1041-1051. doi: 10.1002/mc.23234 PMID: 32537818
  33. Jin, K.; Pandey, N.B.; Popel, A.S. Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis. Breast Cancer Res., 2018, 20(1), 54. doi: 10.1186/s13058-018-0981-3 PMID: 29898755
  34. Yan, J.; Qin, W.; Xiao, B.; Wan, Q.; Tay, F.R.; Niu, L.; Jiao, K. Pathological calcification in osteoarthritis: An outcome or a disease initiator? Biol. Rev. Camb. Philos. Soc., 2020, 95(4), 960-985. doi: 10.1111/brv.12595 PMID: 32207559
  35. Scimeca, M.; Bonfiglio, R.; Menichini, E.; Albonici, L.; Urbano, N.; De Caro, M.T.; Mauriello, A.; Schillaci, O.; Gambacurta, A.; Bonanno, E. Microcalcifications drive breast cancer occurrence and development by macrophage-mediated epithelial to mesenchymal transition. Int. J. Mol. Sci., 2019, 20(22), 5633. doi: 10.3390/ijms20225633 PMID: 31718020
  36. Hsiao, Y.W.; Lu, T.P. Text-mining in cancer research may help identify effective treatments. Transl. Lung Cancer Res., 2019, 8(S4), S460-S463. doi: 10.21037/tlcr.2019.12.20 PMID: 32038938
  37. Zheng, S.; Dharssi, S.; Wu, M.; Li, J.; Lu, Z. Text mining for drug discovery. Methods Mol. Biol., 2019, 1939, 231-252. doi: 10.1007/978-1-4939-9089-4_13 PMID: 30848465
  38. Isayev, O. Text mining facilitates materials discovery. Nature, 2019, 571(7763), 42-43. doi: 10.1038/d41586-019-01978-x PMID: 31270488
  39. Tao, D.; Yang, P.; Feng, H. Utilization of text mining as a big data analysis tool for food science and nutrition. Compr. Rev. Food Sci. Food Saf., 2020, 19(2), 875-894. doi: 10.1111/1541-4337.12540 PMID: 33325182
  40. Wang, L.L.; Lo, K. Text mining approaches for dealing with the rapidly expanding literature on COVID-19. Brief. Bioinform., 2021, 22(2), 781-799. doi: 10.1093/bib/bbaa296 PMID: 33279995
  41. Lee, J.; Yoon, W.; Kim, S.; Kim, D.; Kim, S.; So, C.H.; Kang, J. BioBERT: A pre-trained biomedical language representation model for biomedical text mining. Bioinformatics, 2020, 36(4), 1234-1240. doi: 10.1093/bioinformatics/btz682 PMID: 31501885
  42. Wang, J.H.; Zhao, L.F.; Wang, H.F.; Wen, Y.T.; Jiang, K.K.; Mao, X.M.; Zhou, Z.Y.; Yao, K.T.; Geng, Q.S.; Guo, D.; Huang, Z.X. GenCLiP 3: Mining human genes’ functions and regulatory networks from PubMed based on co-occurrences and natural language processing. Bioinformatics, 2019, 36(6), btz807. doi: 10.1093/bioinformatics/btz807 PMID: 31681951
  43. Wang, J.H.; Zhao, L.F.; Lin, P.; Su, X.R.; Chen, S.J.; Huang, L.Q.; Wang, H.F.; Zhang, H.; Hu, Z.F.; Yao, K.T.; Huang, Z.X. GenCLiP 2.0: A web server for functional clustering of genes and construction of molecular networks based on free terms. Bioinformatics, 2014, 30(17), 2534-2536. doi: 10.1093/bioinformatics/btu241 PMID: 24764463
  44. Zhang, N.; Xu, W.; Wang, S.; Qiao, Y.; Zhang, X. Computational drug discovery in chemotherapy-induced alopecia via text mining and biomedical databases. Clin. Ther., 2019, 41(5), 972-980.e8. doi: 10.1016/j.clinthera.2019.04.003 PMID: 31030996
  45. Kirk, J.; Shah, N.; Noll, B.; Stevens, C.B.; Lawler, M.; Mougeot, F.B.; Mougeot, J.L.C. Text mining-based in silico drug discovery in oral mucositis caused by high-dose cancer therapy. Support. Care Cancer, 2018, 26(8), 2695-2705. doi: 10.1007/s00520-018-4096-2 PMID: 29476419
  46. Hu, D.; Jiang, J.; Lin, Z.; Zhang, C.; Moonasar, N.; Qian, S. Identification of key genes and pathways in scleral extracellular matrix remodeling in glaucoma: Potential therapeutic agents discovered using bioinformatics analysis. Int. J. Med. Sci., 2021, 18(7), 1554-1565. doi: 10.7150/ijms.52846 PMID: 33746571
  47. Szklarczyk, D.; Gable, A.L.; Nastou, K.C.; Lyon, D.; Kirsch, R.; Pyysalo, S.; Doncheva, N.T.; Legeay, M.; Fang, T.; Bork, P.; Jensen, L.J.; von Mering, C. The STRING database in 2021: Customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res., 2021, 49(D1), D605-D612. doi: 10.1093/nar/gkaa1074 PMID: 33237311
  48. Yi, L.; Wu, G.; Guo, L.; Zou, X.; Huang, P. Comprehensive analysis of the PD-L1 and immune infiltrates of m6A RNA methylation regulators in head and neck squamous cell carcinoma. Mol. Ther. Nucleic Acids, 2020, 21, 299-314. doi: 10.1016/j.omtn.2020.06.001 PMID: 32622331
  49. Koh, Y.W.; Han, J.H.; Haam, S.; Jung, J.; Lee, H.W. Increased CMTM6 can predict the clinical response to PD-1 inhibitors in non-small cell lung cancer patients. OncoImmunol., 2019, 8(10), e1629261. doi: 10.1080/2162402X.2019.1629261 PMID: 31646074
  50. Hoadley, K.A.; Yau, C.; Wolf, D.M.; Cherniack, A.D.; Tamborero, D.; Ng, S.; Leiserson, M.D.M.; Niu, B.; McLellan, M.D.; Uzunangelov, V.; Zhang, J.; Kandoth, C.; Akbani, R.; Shen, H.; Omberg, L.; Chu, A.; Margolin, A.A.; van’t Veer, L.J.; Lopez-Bigas, N.; Laird, P.W.; Raphael, B.J.; Ding, L.; Robertson, A.G.; Byers, L.A.; Mills, G.B.; Weinstein, J.N.; Van Waes, C.; Chen, Z.; Collisson, E.A.; Benz, C.C.; Perou, C.M.; Stuart, J.M. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell, 2014, 158(4), 929-944. doi: 10.1016/j.cell.2014.06.049 PMID: 25109877
  51. Iglesia, M.D.; Parker, J.S.; Hoadley, K.A.; Serody, J.S.; Perou, C.M.; Vincent, B.G. Genomic analysis of immune cell infiltrates across 11 tumor types. J. Natl. Cancer Inst., 2016, 108(11), djw144. doi: 10.1093/jnci/djw144 PMID: 27335052
  52. Zhou, Y.; Zhou, B.; Pache, L.; Chang, M.; Khodabakhshi, A.H.; Tanaseichuk, O.; Benner, C.; Chanda, S.K. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun., 2019, 10(1), 1523. doi: 10.1038/s41467-019-09234-6 PMID: 30944313
  53. Tang, Z.; Li, C.; Kang, B.; Gao, G.; Li, C.; Zhang, Z. GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res., 2017, 45(W1), W98-W102. doi: 10.1093/nar/gkx247 PMID: 28407145
  54. Tang, Z.; Kang, B.; Li, C.; Chen, T.; Zhang, Z. GEPIA2: An enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res., 2019, 47(W1), W556-W560. doi: 10.1093/nar/gkz430 PMID: 31114875
  55. Li, C.; Tang, Z.; Zhang, W.; Ye, Z.; Liu, F. GEPIA2021: Integrating multiple deconvolution-based analysis into GEPIA. Nucleic Acids Res., 2021, 49(W1), W242-W246. doi: 10.1093/nar/gkab418 PMID: 34050758
  56. Cotto, K.C.; Wagner, A.H.; Feng, Y.Y.; Kiwala, S.; Coffman, A.C.; Spies, G.; Wollam, A.; Spies, N.C.; Griffith, O.L.; Griffith, M. DGIdb 3.0: A redesign and expansion of the drug–gene interaction database. Nucleic Acids Res., 2018, 46(D1), D1068-D1073. doi: 10.1093/nar/gkx1143 PMID: 29156001
  57. Wishart, D.S.; Feunang, Y.D.; Guo, A.C.; Lo, E.J.; Marcu, A.; Grant, J.R.; Sajed, T.; Johnson, D.; Li, C.; Sayeeda, Z.; Assempour, N.; Iynkkaran, I.; Liu, Y.; Maciejewski, A.; Gale, N.; Wilson, A.; Chin, L.; Cummings, R.; Le, D.; Pon, A.; Knox, C.; Wilson, M. DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Res., 2018, 46(D1), D1074-D1082. doi: 10.1093/nar/gkx1037 PMID: 29126136
  58. Nelson, A.E.; Allen, K.D.; Golightly, Y.M.; Goode, A.P.; Jordan, J.M. A systematic review of recommendations and guidelines for the management of osteoarthritis: The Chronic Osteoarthritis Management Initiative of the U.S. Bone and Joint Initiative. Semin. Arthritis Rheum., 2014, 43(6), 701-712. doi: 10.1016/j.semarthrit.2013.11.012 PMID: 24387819
  59. Block, J.A. OA guidelines: Improving care or merely codifying practice? Nat. Rev. Rheumatol., 2014, 10(6), 324-326. doi: 10.1038/nrrheum.2014.61 PMID: 24752185
  60. Hunter, D.J.; Bierma-Zeinstra, S. Osteoarthritis. Lancet, 2019, 393(10182), 1745-1759. doi: 10.1016/S0140-6736(19)30417-9 PMID: 31034380
  61. Ferguson, R.J.; Palmer, A.J.R.; Taylor, A.; Porter, M.L.; Malchau, H.; Glyn-Jones, S. Hip replacement. Lancet, 2018, 392(10158), 1662-1671. doi: 10.1016/S0140-6736(18)31777-X PMID: 30496081
  62. Carr, A.J.; Robertsson, O.; Graves, S.; Price, A.J.; Arden, N.K.; Judge, A.; Beard, D.J. Knee replacement. Lancet, 2012, 379(9823), 1331-1340. doi: 10.1016/S0140-6736(11)60752-6 PMID: 22398175
  63. Smith-Turchyn, J.; Mukherjee, S.; Richardson, J.; Ball, E.; Bordeleau, L.; Neil-Sztramko, S.; Levine, O.; Thabane, L.; Sathiyapalan, A.; Sabiston, C. Evaluation of a novel strategy to implement exercise evidence into clinical practice in breast cancer care: protocol for the NEXT-BRCA randomised controlled trial. BMJ Open Sport Exerc. Med., 2020, 6(1), e000922. doi: 10.1136/bmjsem-2020-000922 PMID: 33178447
  64. Furmaniak, A.C.; Menig, M.; Markes, M.H. Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Libr., 2016, 2016(9), CD005001. doi: 10.1002/14651858.CD005001.pub3 PMID: 27650122
  65. Ferket, B.S.; Feldman, Z.; Zhou, J.; Oei, E.H.; Bierma-Zeinstra, S.M.A.; Mazumdar, M. Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative. BMJ, 2017, 356, j1131. doi: 10.1136/bmj.j1131 PMID: 28351833
  66. Tankó, L.B.; Søndergaard, B.C.; Oestergaard, S.; Karsdal, M.A.; Christiansen, C. An update review of cellular mechanisms conferring the indirect and direct effects of estrogen on articular cartilage. Climacteric, 2008, 11(1), 4-16. doi: 10.1080/13697130701857639 PMID: 18202960
  67. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Aromatase inhibitors versus tamoxifen in early breast cancer: Patient-level meta-analysis of the randomised trials. Lancet, 2015, 386(10001), 1341-1352. doi: 10.1016/S0140-6736(15)61074-1 PMID: 26211827
  68. Goldvaser, H.; Barnes, T.A.; Šeruga, B.; Cescon, D.W.; Ocaña, A.; Ribnikar, D.; Amir, E. Toxicity of extended adjuvant therapy with aromatase inhibitors in early breast cancer: A systematic review and meta-analysis. J. Natl. Cancer Inst., 2018, 110(1), 31-39. doi: 10.1093/jnci/djx141 PMID: 28922781
  69. Coleman, R.; Body, J.J.; Aapro, M.; Hadji, P.; Herrstedt, J. Bone health in cancer patients. ESMO Clinical Practice Guidelines. Ann. Oncol., 2014, 25(S3), iii124-iii137. doi: 10.1093/annonc/mdu103 PMID: 24782453
  70. Shapiro, C.L.; Recht, A. Late effects of adjuvant therapy for breast cancer. J. Natl. Cancer Inst. Monogr., 1994, (16), 101-112. PMID: 7999452
  71. Henry, N.L.; Giles, J.T.; Ang, D.; Mohan, M.; Dadabhoy, D.; Robarge, J.; Hayden, J.; Lemler, S.; Shahverdi, K.; Powers, P.; Li, L.; Flockhart, D.; Stearns, V.; Hayes, D.F.; Storniolo, A.M.; Clauw, D.J. Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. Breast Cancer Res. Treat., 2008, 111(2), 365-372. doi: 10.1007/s10549-007-9774-6 PMID: 17922185
  72. Mao, J.J.; Stricker, C.; Bruner, D.; Xie, S.; Bowman, M.A.; Farrar, J.T.; Greene, B.T.; DeMichele, A. Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors. Cancer, 2009, 115(16), 3631-3639. doi: 10.1002/cncr.24419 PMID: 19517460
  73. Milstone, Z.J.; Lawson, G.; Trivedi, C.M. Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development, and craniofacial morphogenesis. Dev. Dyn., 2017, 246(12), 1015-1026. doi: 10.1002/dvdy.24563 PMID: 28791750
  74. Krämer, O.H. HDAC2: A critical factor in health and disease. Trends Pharmacol. Sci., 2009, 30(12), 647-655. doi: 10.1016/j.tips.2009.09.007 PMID: 19892411
  75. Riccio, A. New endogenous regulators of class I histone deacetylases. Sci. Signal., 2010, 3(103), pe1. doi: 10.1126/scisignal.3103pe1 PMID: 20051592
  76. Lee, Y.H.; Seo, D.; Choi, K.J.; Andersen, J.B.; Won, M.A.; Kitade, M.; Gómez-Quiroz, L.E.; Judge, A.D.; Marquardt, J.U.; Raggi, C.; Conner, E.A.; MacLachlan, I.; Factor, V.M.; Thorgeirsson, S.S. Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2. Cancer Res., 2014, 74(17), 4752-4761. doi: 10.1158/0008-5472.CAN-13-3531 PMID: 24958469
  77. Kiweler, N.; Brill, B.; Wirth, M.; Breuksch, I.; Laguna, T.; Dietrich, C.; Strand, S.; Schneider, G.; Groner, B.; Butter, F.; Heinzel, T.; Brenner, W.; Krämer, O.H. The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells. Arch. Toxicol., 2018, 92(7), 2227-2243. doi: 10.1007/s00204-018-2229-5 PMID: 29845424
  78. Huang, W.T.; Tsai, Y.H.; Chen, S.H.; Kuo, C.W.; Kuo, Y.L.; Lee, K.T.; Chen, W.C.; Wu, P.C.; Chuang, C.Y.; Cheng, S.M.; Lin, C.H.; Leung, E.Y.; Chang, Y.C.; Cheung, C.H.A. HDAC2 and HDAC5 up-regulations modulate survivin and miR-125a-5p expressions and promote hormone therapy resistance in estrogen receptor positive breast cancer cells. Front. Pharmacol., 2017, 8, 902. doi: 10.3389/fphar.2017.00902 PMID: 29326587
  79. Darvishi, N.; Rahimi, K.; Mansouri, K.; Fathi, F.; Menbari, M.N.; Mohammadi, G.; Abdi, M. MiR-646 prevents proliferation and progression of human breast cancer cell lines by suppressing HDAC2 expression. Mol. Cell. Probes, 2020, 53, 101649. doi: 10.1016/j.mcp.2020.101649 PMID: 32777446
  80. Bayat, S.; Mansoori, D.S.; Mansoori, D.N.; Shekari, K.M.; Alivand, M.R. Downregulation of HDAC2 and HDAC3via oleuropein as a potent prevention and therapeutic agent in MCF-7 breast cancer cells. J. Cell. Biochem., 2019, 120(6), 9172-9180. doi: 10.1002/jcb.28193 PMID: 30618185
  81. Zhang, N.; Zhang, H.; Liu, Y.; Su, P.; Zhang, J.; Wang, X.; Sun, M.; Chen, B.; Zhao, W.; Wang, L.; Wang, H.; Moran, M.S.; Haffty, B.G.; Yang, Q. SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2. Cell Death Differ., 2019, 26(5), 843-859. doi: 10.1038/s41418-018-0158-8 PMID: 29988076
  82. Zhang, Z.; Qiu, N.; Yin, J.; Zhang, J.; Liu, H.; Guo, W.; Liu, M.; Liu, T.; Chen, D.; Luo, K.; Li, H.; He, Z.; Liu, J.; Zheng, G. SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression. Theranostics, 2020, 10(10), 4290-4307. doi: 10.7150/thno.41008 PMID: 32292495
  83. Roy, S.S.; Gonugunta, V.K.; Bandyopadhyay, A.; Rao, M.K.; Goodall, G.J.; Sun, L-Z.; Tekmal, R.R.; Vadlamudi, R.K. Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. Oncogene, 2014, 33(28), 3707-3716. doi: 10.1038/onc.2013.332 PMID: 23975430
  84. Fu, J.; Qin, L.; He, T.; Qin, J.; Hong, J.; Wong, J.; Liao, L.; Xu, J. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res., 2011, 21(2), 275-289. doi: 10.1038/cr.2010.118 PMID: 20714342
  85. Wang, Z.; Zhou, N.; Wang, W.; Yu, Y.; Xia, L.; Li, N. HDAC2 interacts with microRNA-503-5p to regulate SGK1 in osteoarthritis. Arthritis Res. Ther., 2021, 23(1), 78. doi: 10.1186/s13075-020-02373-y PMID: 33750441
  86. Mao, G.; Zhang, Z.; Huang, Z.; Chen, W.; Huang, G.; Meng, F.; Zhang, Z.; Kang, Y. MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation. Osteoarthr. Cartil., 2017, 25(4), 521-532. doi: 10.1016/j.joca.2016.11.006 PMID: 27884646
  87. Culley, K.L.; Hui, W.; Barter, M.J.; Davidson, R.K.; Swingler, T.E.; Destrument, A.P.M.; Scott, J.L.; Donell, S.T.; Fenwick, S.; Rowan, A.D.; Young, D.A.; Clark, I.M. Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. Arthritis Rheum., 2013, 65(7), 1822-1830. doi: 10.1002/art.37965 PMID: 23575963
  88. van Tilborg, A.A.G.; de Vries, A.; Zwarthoff, E.C. The chromosome 9q genesTGFBR1,TSC1, andZNF189 are rarely mutated in bladder cancer. J. Pathol., 2001, 194(1), 76-80. doi: 10.1002/path.860 PMID: 11329144
  89. Daley, D.; Morgan, W.; Lewis, S.; Willis, J.; Elston, R.C.; Markowitz, S.D.; Wiesner, G.L. Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia? Cancer Epidemiol. Biomarkers Prev., 2007, 16(5), 892-894. doi: 10.1158/1055-9965.EPI-06-0965 PMID: 17507611
  90. Bose, S.; Morgan, L.J.; Booth, D.R.; Goudie, D.R.; Ferguson-Smith, M.A.; Richards, F.M. The elusive multiple self-healing squamous epithelioma (MSSE) gene: Further mapping, analysis of candidates, and loss of heterozygosity. Oncogene, 2006, 25(5), 806-812. doi: 10.1038/sj.onc.1209092 PMID: 16170343
  91. Siegel, P.M.; Massagué, J. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat. Rev. Cancer, 2003, 3(11), 807-820. doi: 10.1038/nrc1208 PMID: 14557817
  92. Pasche, B.; Knobloch, T.J.; Bian, Y.; Liu, J.; Phukan, S.; Rosman, D.; Kaklamani, V.; Baddi, L.; Siddiqui, F.S.; Frankel, W.; Prior, T.W.; Schuller, D.E.; Agrawal, A.; Lang, J.; Dolan, M.E.; Vokes, E.E.; Lane, W.S.; Huang, C.C.; Caldes, T.; Di Cristofano, A.; Hampel, H.; Nilsson, I.; von Heijne, G.; Fodde, R.; Murty, V.V.; de la Chapelle, A.; Weghorst, C.M. Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA, 2005, 294(13), 1634-1646. doi: 10.1001/jama.294.13.1634 PMID: 16204663
  93. Lei, B.; Wang, D.; Zhang, M.; Deng, Y.; Jiang, H.; Li, Y. miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis. J. Exp. Clin. Cancer Res., 2020, 39(1), 71. doi: 10.1186/s13046-020-01571-5 PMID: 32336285
  94. Schmierer, B.; Hill, C.S. TGFβ–SMAD signal transduction: Molecular specificity and functional flexibility. Nat. Rev. Mol. Cell Biol., 2007, 8(12), 970-982. doi: 10.1038/nrm2297 PMID: 18000526
  95. Wrana, J.L.; Attisano, L.; Wieser, R.; Ventura, F.; Massagué, J. Mechanism of activation of the TGF-β receptor. Nature, 1994, 370(6488), 341-347. doi: 10.1038/370341a0 PMID: 8047140
  96. Liu, Y.Y.; Zhang, S.; Yu, T.J.; Zhang, F.L.; Yang, F.; Huang, Y.N.; Ma, D.; Liu, G.Y.; Shao, Z.M.; Li, D.Q. Pregnancy-specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF‐β/Smad signaling to drive breast cancer progression. Clin. Transl. Med., 2020, 10(8), e245. doi: 10.1002/ctm2.245 PMID: 33377651
  97. Park, C.Y.; Son, J.Y.; Jin, C.H.; Nam, J.S.; Kim, D.K.; Sheen, Y.Y. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung. Eur. J. Cancer, 2011, 47(17), 2642-2653. doi: 10.1016/j.ejca.2011.07.007 PMID: 21852112
  98. Wang, S.; Huang, M.; Wang, Z.; Wang, W.; Zhang, Z.; Qu, S.; Liu, C. MicroRNA 133b targets TGF‐β receptor I to inhibit TGF‐β-induced epithelial to mesenchymal transition and metastasis by suppressing the TGF‐β/SMAD pathway in breast cancer. Int. J. Oncol., 2019, 55(5), 1097-1109. doi: 10.3892/ijo.2019.4879 PMID: 31545407
  99. Wu, Y.; Tran, T.; Dwabe, S.; Sarkissyan, M.; Kim, J.; Nava, M.; Clayton, S.; Pietras, R.; Farias-Eisner, R.; Vadgama, J.V. A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells. Breast Cancer Res. Treat., 2017, 163(3), 449-460. doi: 10.1007/s10549-017-4211-y PMID: 28337662
  100. Liu, W.; Feng, M.; Jayasuriya, C.T.; Peng, H.; Zhang, L.; Guan, Y.; Froehlich, J.A.; Terek, R.M.; Chen, Q. Human osteoarthritis cartilage-derived stromal cells activate joint degeneration through TGF-beta lateral signaling. FASEB J., 2020, 34(12), 16552-16566. doi: 10.1096/fj.202001448R PMID: 33118211
  101. Li, Z.; Kupcsik, L.; Yao, S.J.; Alini, M.; Stoddart, M.J. Mechanical load modulates chondrogenesis of human mesenchymal stem cells through the TGF-β pathway. J. Cell. Mol. Med., 2010, 14(6a), 1338-1346. doi: 10.1111/j.1582-4934.2009.00780.x PMID: 19432813
  102. Blaney Davidson, E.N.; Vitters, E.L.; van der Kraan, P.M.; van den Berg, W.B. Expression of transforming growth factor- (TGF) and the TGF signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann. Rheum. Dis., 2006, 65(11), 1414-1421. doi: 10.1136/ard.2005.045971 PMID: 16439443
  103. Dong, M.; Ning, Z.Q.; Xing, P.Y.; Xu, J.L.; Cao, H.X.; Dou, G.F.; Meng, Z.Y.; Shi, Y.K.; Lu, X.P.; Feng, F.Y. Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas. Cancer Chemother. Pharmacol., 2012, 69(6), 1413-1422. doi: 10.1007/s00280-012-1847-5 PMID: 22362161
  104. Ning, Z.Q.; Li, Z.B.; Newman, M.J.; Shan, S.; Wang, X.H.; Pan, D.S.; Zhang, J.; Dong, M.; Du, X.; Lu, X.P. Chidamide (CS055/HBI-8000): A new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother. Pharmacol., 2012, 69(4), 901-909. doi: 10.1007/s00280-011-1766-x PMID: 22080169
  105. Lu, X.; Ning, Z.; Li, Z.; Cao, H.; Wang, X. Development of chidamide for peripheral T-cell lymphoma, the first orphan drug approved in China. Intractable Rare Dis. Res., 2016, 5(3), 185-191. doi: 10.5582/irdr.2016.01024 PMID: 27672541
  106. Gao, S.; Li, X.; Zang, J.; Xu, W.; Zhang, Y. Preclinical and clinical studies of chidamide (CS055/HBI-8000), An orally available subtype-selective HDAC inhibitor for cancer therapy. Anticancer. Agents Med. Chem., 2017, 17(6), 802-812. PMID: 27592546
  107. Lazarova, D.; Bordonaro, M. ZEB1 mediates drug resistance and EMT in p300-Deficient CRC. J. Cancer, 2017, 8(8), 1453-1459. doi: 10.7150/jca.18762 PMID: 28638460
  108. Su, Y.; Hopfinger, N.R.; Nguyen, T.D.; Pogash, T.J.; Santucci-Pereira, J.; Russo, J. Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors. J. Exp. Clin. Cancer Res., 2018, 37(1), 314. doi: 10.1186/s13046-018-0988-8 PMID: 30547810
  109. Tsiftsoglou, A.S.; Bonovolias, I.D.; Tsiftsoglou, S.A. Multilevel targeting of hematopoietic stem cell self-renewal, differentiation and apoptosis for leukemia therapy. Pharmacol. Ther., 2009, 122(3), 264-280. doi: 10.1016/j.pharmthera.2009.03.001 PMID: 19306896
  110. Salvador, M.A.; Wicinski, J.; Cabaud, O.; Toiron, Y.; Finetti, P.; Josselin, E.; Lelièvre, H.; Kraus-Berthier, L.; Depil, S.; Bertucci, F.; Collette, Y.; Birnbaum, D.; Charafe-Jauffret, E.; Ginestier, C. The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression. Clin. Cancer Res., 2013, 19(23), 6520-6531. doi: 10.1158/1078-0432.CCR-13-0877 PMID: 24141629
  111. Hii, L.W.; Chung, F.F.L.; Soo, J.S.S.; Tan, B.S.; Mai, C.W.; Leong, C.O. Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously. Breast Cancer Res. Treat., 2020, 179(3), 615-629. doi: 10.1007/s10549-019-05504-5 PMID: 31784862
  112. Zhang, Q.; Wang, T.; Geng, C.; Zhang, Y.; Zhang, J.; Ning, Z.; Jiang, Z. Exploratory clinical study of chidamide, an oral subtypeselective histone deacetylase inhibitor, in combination with exemestane in hormone receptor-positive advanced breast cancer. Chin. J. Cancer Res., 2018, 30(6), 605-612. doi: 10.21147/j.issn.1000-9604.2018.06.05 PMID: 30700929

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