The Relationship of Inflammation with Energetic Metabolism and Mitochondrial Dysfunction in Autistic Spectrum Disorders

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

According to the totality of inflammatory markers, a cluster of patients with autism spectrum disorders (ASD) and high levels of inflammation (N = 35, 70%) was identified. Discriminant analysis showed that the catabolite of the kynurenine pathway, which makes the greatest contribution to the pathogenesis of RAS, is quinolic acid. Dysregulation of energy metabolism has been revealed, including both the main pathways of catabolism (glycolysis, the Krebs cycle) and alternative pathways (beta-oxidation, ketogenesis, branched amino acid metabolism) with impaired mitochondrial function (meglutol) in patients with ASD. Correlations have been revealed for a number of energy exchange metabolites with indicators of inflammation. Inflammation in ASD is associated with dysregulation of energy metabolism and mitochondrial dysfunction. These data can serve as the basis for new treatment protocols, including anti-inflammatory therapy, metabolic correction, and restoration of mitochondrial function.

全文:

受限制的访问

作者简介

V. Generalov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

T. Klushnik

Medical Center “PlanetaMed”

编辑信件的主要联系方式.
Email: klushnik2004@mail.ru
韩国, Moscow

T. Obodzinskaya

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

G. Larionov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

A. Aleksandrenkova

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

T. Sadykov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

A. Yugai

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

Yu. Kazakova

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

L. Mamedov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
俄罗斯联邦, Moscow

参考

  1. Баландина О.В., Бондарь Е.А., Власов В.В., Григоренко Е.Л., Кузнецова Ю.Е., Кузюкова А.А., Лебедева Е.И., Мартынихин И.А., Менделевич В.Д., Мешкова Е.С., Намазова-Баранова Л.С., Новиков А.Ю., Осин Е.К., Портнова А.А., Рачин А.П., Романова Р.С., Сиволап Ю.П., Таланцева О.И., Устинова Н.В., Шарков А.А. // Клин. рекомендации “Расстройства аутистического спектра” 2024 ID: 594_3.
  2. Zeidan J., Fombone E., Scorah J., Ibrahim A., Durkin M.S., Saxena S., Yusuf A., Shih A., Elsabbagh M. Autism Research. 2022. V. 15. № 5. P. 778–790.
  3. Hughes H.K., Moreno R.J., Ashwood P. // Brain, Behavior, and Immunity. 2023. V.108 P. 245–254.
  4. Matta S.M., Hill-Yardin E.L., Crack P.J. // Brain, behavior, and immunity. 2019. V. 79. P. 75–90.
  5. Toscano C.V.A., Barros L., Lima A.B., Nunes T., Carvalho H.M., Gaspar J.M. // Neuroscience & Biobehavioral Reviews. 2021. V. 129. P. 63–74.
  6. Liao X., Yang J., Wang H., Li Y. // J. Psychiatr. Res. 2020. V. 130. P. 167–176.
  7. Liao X., Liu Y., Fu X., Li Y. // Molecular neurobiology. 2020. V. 57. P. 3424–3438.
  8. Shen Y., Zhong J.G., Lan W.T., Li Y.H., Gong J.H., Zhao B.X., Hou X.H. // Frontiers in Psychiatry. 2023. V. 14. P. 1086068.
  9. Than U.T.T., Nguyen L.T., Nguyen P.H., Nguyen X.H., Trinh D P., Hoang D.H., Nguyen P.A.T., Dang V.D. // Scientific Reports. 2023. V. 13. № 1. P. 22587.
  10. Клюшник Т.П., Андросова Л.В., Симашкова Н.В., Зозуля С.А., Отман И.Н., Коваль-Зайцев А.А. // Журнал неврологии и психиатрии им. С.С. Корсакова. 2011. Т. 111. № 8. С. 4145.
  11. Hughes H.K., Moreno R.J., Ashwood P. // Brain, behavior, and immunity. 2023. V. 108. P. 245–254.
  12. Wang H., Ye J. // Reviews in Endocrine and Metabolic Disorders. 2015. V. 16. P. 47–54.
  13. Divella R., Gadaleta Caldarola G., Mazzocca A. // Journal of Clinical Medicine. 2022. V. 11. № 8. P. 2191.
  14. Liu X., Jiang N., Zhou W. // Molecules. 2023. V. 28. № 11. P. 4501.
  15. Elkins C., Li C. // Immunometabolism. 2022. V. 4. № 4. P. e00013.
  16. Morrison T., Watts E.R., Sadiku P., Walmsley S.R. // Immunological reviews. 2023. V. 314. № 1. P. 427–441.
  17. Будихина А.С., Пащенков М.В. // Иммунология. 2021. V. 42. № 1. P. 5–20.
  18. Симашкова Н.В., Клюшник Т.П., Якупова Л.П. // Психиатрия. 2018. Т. 78. № 2. С. 17–24.
  19. Доценко В.Л., Нешкова Е.А., Яровая Г.А. Вопр. мед. хим. 1994. Т. 40. № 3. С. 20–25.
  20. Нартикова В.Ф., Пасхина Т.С. // Вопр. мед. хим. 1979. Т. 25. № 4. С. 494–499.
  21. Скрипченко Н.В., Широкова А.С. // Нейрохирургия и неврология детского возраста. 2016. № 4. С. 16–25.
  22. Abou Chahla M.N., Khalil M.I., Comai S., Brundin L., Erhardt S., Guillemin G.J. // Brain Sciences. 2023. V. 13. № 3. P. 505.
  23. Шилов Ю.Е., Безруков М.В. // Вестник Российской академии медицинских наук. 2013. Т. 68. № 1. С. 35–41.
  24. Klyushnik T.P., Ivanov A.B., Petrov V.G. // Journal of Neurology and Psychiatry named after S.S. Korsakov. 2014. V. 114. № 2. P. 37.
  25. Зозуля С.А., Смирнова Л.К., Кузнецов Н.Е. // Психическое здоровье. 2017. Т. 15. №1. С. 11–18.
  26. Santana-Coelho D. // Brain, Behavior, & Immunity-Health. 2024. P. 10083
  27. Gevi F., Zolla L., Gabriele S., Persico A.M. // Molecular Autism. 2016. V. 7. P. 1–11.
  28. Saade M.C., Clark A.J., Parikh S.M. // Frontiers in Nutrition. 2022. V. 9. P. 1070435.
  29. Kominsky D.J., Campbell E.L., Colgan S.P. // The Journal of Immunology. 2010. V. 184. № 8. P. 4062–4068.
  30. Анашкина А.А., Ерлыкина Е.И. // Современные технологии в медицине. 2021. Т. 13. № 1. С. 78–92.
  31. Ye Z., Wang S., Zhang X., Li H., Xu Z., Zuo Y. // Frontiers in Endocrinology. 2020. V. 11. P. 617.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Russian Academy of Sciences, 2025