MORPHOLOGIC SPECIFICITIES OF HEPATOPROTECTIVE EFFECTS OF ANTIHYPOXANTS IN EXPERIMENTAL ACUTE LIVER DAMAGE WITH CARBON TETRACHLORIDE

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

The article presents the results on liver morphologic changes in acute carbon tetrachloride damage and its preventive correction by antihypoxants: complex oxymethyluracil agents (with sodium succinate and ascorbic acid). It has been shown that carbon tetrachloride causes pronounced morphologic changes in the liver and preventive use of the antihypoxants studied decreases intensity and prevalence of dystrophic processes in liver tissues. The analysis of comparative efficiency of the agents studied has been carried out.

Авторлар туралы

E. Repina

Ufa Institute of Occupational Health and Human Ecology

Хат алмасуға жауапты Автор.
Email: e.f.repina@bk.ru

Repina Elvira Faridovna

450106, Ufa


Ресей

N. Khusnutdinova

Ufa Institute of Occupational Health and Human Ecology

Email: fake@neicon.ru

Khusnutdinova Nadezhda Yurevna 

450106, Ufa

 

Ресей

G. Timasheva

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru

Timasheva Gulnara Vilevna 

450106, Ufa


Ресей

S. Baigil’din

Ufa Institute of Occupational Health and Human Ecology

Email: baigildin.samat@yandex.ru

Baigildin Samat Sagadatovich

450106, Ufa


Ресей

D. Karimov

Ufa Institute of Occupational Health and Human Ecology

Email: karimovdo@gmail.com

Karimov Denis Olegovich

450106, Ufa


Ресей

L. Musina

All-Russian Centre of Eye and Plastic Surgery

Email: morphoplant@mail.ru

Musina Lyalya Akhiyarovna

450075, Ufa

Ресей

V. Myshkin

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru

Myshkin Vladimir Alexandrovich

450106, Ufa


Ресей

A. Bakirov

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru

Bakirov Ahat Barievich

450106, Ufa


Ресей

A. Gimadieva

Ufa Institute of Chemistry of the Russian Academy of Science

Email: alf_gim@mail.ru

Gimadieva Alfiya Raisovna

450054, Ufa


Ресей

Әдебиет тізімі

  1. . Golikov S.N., Sanotsky N.V., Tiunov, L.A. General mechanisms of toxic action. M.: Medicine; 1986; p. 279 (in Russian).
  2. Okovityi S.N., Smirnov A.V. Antihypoxants. Experimental and clinical pharmacology. 2001, 64, p. 76-80 (in Russian).
  3. Abdullayev N.Kh., Karimov Kh.Ya. Liver intoxication with hepatotropic poisons. Tashkent, Medicine, 1989, 96 p. (in Russian).
  4. Bilenko M.V. Ischemic and reperfusion injuries of organs (molecular mechanisms, ways of prevention andtreatment). M., Medicine, 1989, p. 367 (in Russian).
  5. Lukyanova L.D. Pharmacological correction of mitochondrial dysfunction in hypoxia. Problems of hypoxia: molecular, physiological and medical aspects. M, 2004, p. 456-487 (in Russian).
  6. Myshkin V.A., Enikeev D.A. Overcoming of hepatotoxicity with antioxidants: reality and perspective. Ufa, Polygraphdesign; 2014; 182 p. (in Russian).
  7. Myshkin V.A., Bakirov A.B., Repin E.F. Experimental pharmacorrection of toxic liver lesions by antioxidants. Ufa, LLC«Print-2»; 2016; 173 p. (in Russian).
  8. Myshkin V.A., Enikeev D.A., Srubilin D.A., Gimadieva A.R. Experimental evaluation of pyrimidine derivatives on models of liver toxicity: a review. Medical science, 2016; 03, p. 88-98 (in Russian).
  9. Myshkin V.A., Bakirov A.B., Repina E.F., Gimadieva A.R. Hepatoprotection using oxymethyluracil. Information methodical letter, Ufa; 2013; 11 p. (in Russian).
  10. Repina E.F., Gimadieva A.R., Myshkin V.A., Bakirov A.B., Timasheva G.V., Khusnutdinova N.Yu. etc. Antihypoxic activity of a new complex compound of oxymethyluracil with sodium succinate. Toxicological Review, 2017, 2, p. 40-42 (in Russian).
  11. Repina E.F., Myshkin V.A., Karimov D.O., Timasheva G.V., Khusnutdinova N.Yu. Smolyankin D.A. Antihypoxic activity of complex compound of oxymethyluracil with ascorbic acid. Toxicological Review, 2018, 4, p. 20-23 (in Russian).
  12. Merkulov G.A. Course of histopathological techniques. M., Medicine, 1969 (in Russian).

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© Repina E.F., Khusnutdinova N.Y., Timasheva G.V., Baigil’din S.S., Karimov D.O., Musina L.A., Myshkin V.A., Bakirov A.V., Gimadieva A.R., 2019


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