MATERIALS ON SUBSTANTIATION OF HYGIENIC STANDARDS FOR N-PENTYL ETHER OF CHLOROFORMIC ACID IN THE AIR OF THE WORKING AREA AND IN THE ATMOSPHERE

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Abstract

Pentyl chloroformate refers to moderately toxic substances when administered in the stomach (DL50 for white mice 1000,0 ± 86,0 mg/kg), has a pronounced irritant effect on the skin and mucous membrane of the eyes, has no skin-resorptive and sensitizing effect, weakly accumulates in the body. It shows selective irritant effect on the respiratory system on inhalation. The irritant threshold for rats is 7,8 mg/m3, for humans - 2,3 mg/m3. Hygienic standards for pentyl chloroformate are recommended for approval: MAC in the air of the working area - 0,5 mg/m3 (vapors, hazard class 2, marked «requires special protection for the skin and eyes»); tentative safe exposure level in the atmospheric air of populated areas - 0,005 mg/m3.

About the authors

M. V. Bidevkina

Scientific Research Disinfectology Institute

Author for correspondence.
Email: bidevkinamv@niid.ru

Bidevkina Marina Vasil’evna

117246, Moscow

Russian Federation

M. I. Golubeva

Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds

Email: golubevamargo@mail.ru

Golubeva Margarita Ivanovna

142450, Staraya Kupavna, Moscow region

Russian Federation

G. P. Pankratova

Scientific Research Disinfectology Institute

Email: gala@onrush.ru

Pankratova Galina Pavlovna

117246, Moscow Russian Federation

A. V. Limantsev

Scientific Research Disinfectology Institute

Email: av.lim@yandex.ru

Limantsev Anatoliy Vladimirovich

117246, Moscow

Russian Federation

I. N. Razumnaya

Joint-Stock Company All-Union Scientific Center for the Safety of Biologically Active Compounds

Email: fake@neicon.ru

Razumnaja Irina Nikolaevna

142450, Staraya Kupavna, Moscow region

Russian Federation

А. L. Karaev

Scientific Research Disinfectology Institute

Email: karayev-al@mail.ru

Karaev Andrey Lvovich

117246, Moscow

Russian Federation

T. N. Potapova

Scientific Research Disinfectology Institute

Email: potapovatn@niid.ru

Potapova Tat’yana Nikolaevna

117246, Moscow

Russian Federation

References

  1. Harmful substances in the environment. Oxygenated organic compounds. Part III. Ed. V.A. Filova, B.A. Ivina, Yu.I. Musiychuka. SPb .: ANO NPO Professional; 2004:237-240.(in Russian)
  2. Guidelines for the formulation of studies on the study of irritant properties and the justification of the maximum allowable concentrations of selectively acting irritants in the air of the working area. MU number 2196-80. M., USSR Ministry of Health; 1980. (in Russian)
  3. Guidelines for the establishment of approximate safe levels of exposure to harmful substances in the air of the working area. MU number 4000-85. M., USSR Ministry of Health; 1985. (in Russian)
  4. Requirements for the formulation of experimental studies to substantiate the maximum allowable concentrations of industrial allergens in the air of the working area and atmosphere. MU number 1.1.578-96. M.; 1996. (in Russian)
  5. Guidelines for the establishment of approximate safe exposure levels (TSEL) of pollutants in the atmospheric air of populated areas. MU No. 2630-82-88.M, Ministry of Health of the USSR; 1988. (in Russian)

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Copyright (c) 2019 Bidevkina M.V., Golubeva M.I., Pankratova G.P., Limantsev A.V., Razumnaya I.N., Karaev А.L., Potapova T.N.


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