Metal-free reductive c-c-coupling between arylboronic acids and 2-(5-iodo-1,2,3-triazolyl)phenols

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Abstract

A novel approach to 2-(1-arylalkyl)benzoxazoles via a reaction of arylboronic acids with 2-(5-iodo-1,2,3-triazolyl)phenols has been developed. The key intermediates of the proposed cascade transformation are 2-(1-diazoalkyl)benzoxazoles, entering reductive C-C-coupling with boronic acids. The reaction proceeds under transition-metal-free conditions and affords target compounds in yields up to 67%.

About the authors

A. G. Gevondian

M.V. Lomonosov Moscow State University

Y. N. Kotovshchikov

M.V. Lomonosov Moscow State University

Email: kotovshchikov@org.chem.msu.ru

G. V. Latyshev

M.V. Lomonosov Moscow State University

N. V. Lukashev

M.V. Lomonosov Moscow State University

I. P. Beletskaya

M.V. Lomonosov Moscow State University

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