МикроРНК гиппокампа в механизмах индукции депрессивно-подобного поведения стрессорными воздействиями

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Патогенез депрессивных расстройств связывают с дисбалансом нейротрансмиттеров в мозге, эндокринными нарушениями, провоспалительными и нейродегенеративными процессами, поэтому не удивительно, что терапия классическими антидепрессантами, направленная на отдельные системы, зачастую оказывается малоэффективной и, более того, может вызывать нежелательные побочные эффекты. Необходимость поиска новых механизмов патологии с целью возможного их использования в качестве потенциальных мишеней при разработке более действенных терапевтических средств привлекла внимание к малым некодирующим РНК (микроРНК). Эти микроРНК, регулирующие экспрессию целевых генов на посттранскрипционном уровне, вовлекаются в центральной нервной системе в механизмы чувствительности и устойчивости к стрессорным воздействиям – общепринятым факторам риска депрессии. Настоящий обзор посвящен систематизации и анализу результатов, полученных на грызунах, о микроРНК и сигнальных путях их участия в развитии депрессивно-подобного состояния в условиях хронического стресса путем регуляции нейровоспаления, нейрогенеза, cинаптической пластичности и апоптоза в гиппокампе. Результаты проведенного анализа подтверждают представление о сложной регуляторной сети, вовлеченной в инициирование и поддержание этого психоэмоционального расстройства, что может способствовать разработке адекватных терапевтических средств, направленных на борьбу с заболеванием.

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Г. Т. Шишкина

Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук

Автор, ответственный за переписку.
Email: gtshi@bionet.nsc.ru
Россия, 630090, Новосибирск

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