Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework

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Biocompatible metal-organic framework MIL-100(Fe) was used as a container for a model hydrophobic active pharmaceutical ingredient, ibuprofen, in composite films based on gelatin, pectin, and kappacarrageenan. According to powder X-ray diffraction and scanning electron microscopy data, the metal-organic framework retained the crystal structure and its particles were uniformly distributed throughout the hydrocolloid matrix. Testing of the obtained film materials under simulated biological conditions using chromatography – mass spectrometry analysis showed that they are applicable as a dosage form for slow release of active pharmaceutical ingredients.

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作者简介

A. Pak

Nesmeyanov Institute of Organic Element Compounds, Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)

Email: novikov84@gmail.com
俄罗斯联邦, Moscow; Moscow

T. Volkhina

Mendeleev University of Chemical Technology of Russia

Email: novikov84@gmail.com
俄罗斯联邦, Moscow

Yu. Nelyubina

Nesmeyanov Institute of Organic Element Compounds, Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)

Email: novikov84@gmail.com
俄罗斯联邦, Moscow; Moscow

V. Novikov

Moscow Institute of Physics and Technology (National Research University)

编辑信件的主要联系方式.
Email: novikov84@gmail.com
俄罗斯联邦, Moscow

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2. Fig. 1. Photographs of composite films based on Ibuprofen and MIL-100(Fe)_IBU of different compositions. SEM-images of surface fragments were obtained immediately after the films were fabricated.

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3. Fig. 2. Powder X-ray diffraction data for samples of composite films based on Ibuprofen added in amounts of 1, 3 and 5% of the total hydrocolloid mass compared to the theoretically calculated diffractogram of Ibuprofen.

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4. Fig. 3. X-ray powder diffraction data for MIL-100(Fe) and MIL-100(Fe)_IBU samples compared to the theoretically calculated diffractogram of MIL-100(Fe).

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5. Fig. 4. Powder X-ray diffraction data for composite film samples based on MIL-100(Fe)_IBU added in amounts of 1, 3 and 5% of the total hydrocolloid mass compared to the theoretically calculated MIL-100(Fe) diffractogram.

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6. Fig. 5. Release profiles of Ibuprofen from MIL100(Fe)_IBU powder samples and films containing MIL-100(Fe)_IBU.

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