Synthesis and Biological Activity of Esters Based on Cycloalkenedicarboxylic Acids

A. A. Firstova; Фирстова А. А.; E. R. Kofanov; Кофанов Е. Р.; M. I. Kovaleva; Ковалева М. И.

doi:10.31857/S0132342323010086

Synthesis and Biological Activity of Esters Based on Cycloalkenedicarboxylic Acids

Autores: Firstova A.A.¹, Kofanov E.R.¹, Kovaleva M.I.²
Afiliações:
1. Yaroslavl State Technical University
2. Yaroslavl State University named after P.G. Demidov
Edição: Volume 49, Nº 2 (2023)
Páginas: 153-164
Seção: Articles
URL: https://kazanmedjournal.ru/0132-3423/article/view/670646
DOI: https://doi.org/10.31857/S0132342323010086
EDN: https://elibrary.ru/GHIOTR
ID: 670646

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Resumo

Previously undescribed esters based on N-substituted imides of cycloaliphatic carboxylic acids have been synthesized in high yields and efficient methods for their preparation have been presented. Toxicological studies of the obtained compounds were carried out using various test objects (Chlorella vulgaris, Allium cepa, Drosophila melanogaster). It was shown that the studied compounds are not active against D. melanogaster, increase the frequency of mutations in C. vulgaris and have the ability to induce chromosomal rearrangements in A. cepa. The synthesized compounds can be used in the development of antitumor drugs.

Palavras-chave

N-substituted imides of carboxylic acids, esters, cycloalkenyl fragments, L-aminoacid, cytotoxicity, biological activity, mutagenicity

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