Reactions of Pyrimidine-2-sulfenyl Chloride with Alkylvinyl and Allyl Ethers

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Resumo

The regioselective synthesis of novel thiazolo[3,2-a]pyrimidine derivatives in 52–92% yields was developed based on the reaction of pyrimidine-2-sulfenyl chloride with unsaturated ethers. The reaction with allylic and vinylic ethers proceed regioselectively, but with the opposite regiochemistry. The reaction with allylic ethers lead to 2-substituted thiazolo[3,2-a]pyrimidine derivatives whereas 3-organyloxy derivatives are formed in the reaction with vinylic ethers.

Sobre autores

R. Ishigeev

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: v_a_potapov@irioch.irk.ru
ORCID ID: 0000-0003-0843-4818
Rússia, Irkutsk, 664033

S. Amosova

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: v_a_potapov@irioch.irk.ru
ORCID ID: 0000-0002-2874-3725
Rússia, Irkutsk, 664033

V. Potapov

A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Autor responsável pela correspondência
Email: v_a_potapov@irioch.irk.ru
ORCID ID: 0000-0002-3151-6726
Rússia, Irkutsk, 664033

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