Biocompatible microemulsions based on oleic acid modified with piperidinium surfactants

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Abstract

A number of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained and characterized. The effect of additives on the size, stability, and solubilization effect of the formed systems with respect to hydrophilic (rhodamine B) and hydrophobic (indomethacin) substances was studied. By varying the ratio of components, it was possible to form microemulsions that differ greatly in viscosity: from easy-flowing compositions to gels. The kinetic parameters describing release process of substrates from microemulsions have been obtained. In vivo tests of the anti-inflammatory action of microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug. In vivo tests of the anti-inflammatory action of microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug.

About the authors

A. B Mirgorodskaya

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

Email: mirgoralla@mail.ru

R. A Kushnazarova

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

O. A Lenina

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

K. A Petrov

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

L. Ya. Zakharova

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”

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