Functional Design Of Peroral Delivery Systems Based On Polymethylsesquoxane Hydrogels For The Therapy Of Iron Deficiency Anemia

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Abstract

Anemia is a prevalent circulatory system illness that is severely harmful to patients. The development of novel oral delivery systems for iron compounds with enhanced biopharmaceutical properties is vital considering the severe side effects associated with oral medication use. We believe incorporating iron compounds to polymethylsilsesquioxane hydrogels is a promising approach. According to previously published materials, such a system should have great biocompatibility and a capacity for iron compounds, and it may be able to release contents into the intestine. This study investigated polymethysilsesquioxane hydrogels with varying silicate unit concentrations. Potential iron-containing medicines were iron(III) chloride (FeCl3∙6H2O)) and iron(II) D-gluconate. All hydrogels were found to have nearly 100% sorption activity for a saturated solution of FeCl3∙6H2O (0.27 M) during the experiment, but only around 30% sorption capacity was found for a saturated solution of D-gluconate (0.24 M). A specific field of study was the distribution of iron atoms within hydrogels. It has been established that the largest regions devoid of iron atoms are observed in a hydrogel with a maximum quantity of inorganic units. The outcomes provide opportunities for the precise engineering of polymer matrix structures for iron compound delivery.

About the authors

P. D. Orlova

Lomonosov Moscow State University

Email: i.m.deygen@gmail.com

Faculty of fundamental physico-chemical engineering, Faculty of chemistry

Russian Federation, Moscow, 119991

I. B. Meshkov

Institute of synthetic polymer materials

Email: i.m.deygen@gmail.com
Russian Federation, Moscow, 117393

E. V. Latipov

Institute of nanotechnology electronics

Email: i.m.deygen@gmail.com
Russian Federation, Moscow, 115487

S. G. Vasiliev

Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry

Email: i.m.deygen@gmail.com
Russian Federation, Chernogolovka, 142432

A. A. Kalinina

Institute of synthetic polymer materials

Email: i.m.deygen@gmail.com
Russian Federation, Moscow, 117393

A. M. Muzafarov

Institute of synthetic polymer materials

Email: i.m.deygen@gmail.com
Russian Federation, Moscow, 117393

I. M. Le-Deygen

Lomonosov Moscow State University

Author for correspondence.
Email: i.m.deygen@gmail.com

Faculty of chemistry

Russian Federation, Moscow, 119991

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