The substituted derivative of closo-dodecaborate anion based on para-iodo-L-phenylalanine is a novel compound for BNCT with CT imaging capability

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

A substituted derivative of closo-dodecaborate anion [B12H11NH=C(CH3)NHCH2CH-4-I-C6H4(COOCH3)]– containing in its structure elements for vector delivery and diagnostics by beam imaging methods was obtained. The structure of the co-compound was established by multinuclear NMR spectroscopy and ESI-mass spectrometry. For aqueous solutions of the compound Na[B12H11NH=C(CH3)NHCH2CH-4-I-C6H4(COOCH3)], the X-ray density was measured and the distribution of the drug in the organs of laboratory animals was studied by computer tomography.

Авторлар туралы

М. Ryabchikova

National Research University Higher School of Economics

Email: zhdanov@igic.ras.ru
Ресей, Moscow

А. Nelyubin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Ресей, Moscow

Yu. Finogenova

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Ресей, Moscow

V. Skribitsky

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Ресей, Moscow; Moscow

А. Zhdanov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: zhdanov@igic.ras.ru
Ресей, Moscow

А. Lipengolts

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Ресей, Moscow; Moscow

Е. Grigorieva

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Ресей, Moscow

К. Zhizhin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Ресей, Moscow

N. Kuznetsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Ресей, Moscow

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