Preparation of a сloso-Dodecaborate Anion Conjugate with Ethyl Glycinate and Study of Its Biodistribution in a B16f10 Melanoma Model

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

A method for the synthesis of amidine-closo-dodecaborate based on glycine ethyl ester in the form of sodium salt solvate of high purity and constant composition was proposed in this work. The structure of the obtained solvate was confirmed by X-ray analysis of single crystal. In addition, total and acute toxicity as well as biodistribution in laboratory mice with B16F10 melanoma were determined for the synthesized conjugate Na[B12H11NH=C(NHCH2COOC2H5)CH3].

Негізгі сөздер

Толық мәтін

Рұқсат жабық

Авторлар туралы

M. Ryabchikova

National Research University Higher School of Economics

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 101000

A. Nelyubin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 119991

A. Smirnova

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 115522

Y. Finogenova

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 115522

V. Skribitsky

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 115522; Moscow, 115409

K. Shpakova

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 115522; Moscow, 115409

A. Kubasov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 119991

A. Zhdanov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: zhdanov@igic.ras.ru
Ресей, Moscow, 119991

A. Lipengolts

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 115522; Moscow, 115409

E. Grigorieva

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 115522

K. Zhizhin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 119991

N. Kuznetsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Ресей, Moscow, 119991

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2. Fig. 1. The structure of the isopropyl complex according to the RSA data.

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3. Fig. 2. Graph of changes in boron concentration in organs and tissues after intraperitoneal conjugate administration.

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