Nanodiamonds as lutetium-177 carriers for nuclear medicine

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Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
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Рұқсат жабық Тек жазылушылар үшін

Аннотация

The work investigated the sorption of carrier-free 177Lu isolated from neutron-irradiated 176Yb2O3, and with a carrier obtained by irradiation of natLu2O3, by commercial and oxidized nanodiamonds (NDs) of various brands from aqueous solutions to identify among them a promising carrier for further research for the purposes of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP brand (ox-STP); conditions for the rapid sorption of lutetium by it in an amount equivalent to 1.2 GBq of carrier-free 177Lu were determined, which corresponds to the activity used in therapy.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Kazakov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: adeptak92@mail.ru
Ресей, Moscow

J. Babenya

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

T. Ekatova

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

S. Vinokurov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

E. Khvorostinin

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow

I. Ushakov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

V. Zukau

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

E. Stasyuk

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

E. Nesterov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

V. Sadkin

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

A. Rogov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Ресей, Tomsk

B. Myasoedov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences

Email: adeptak92@mail.ru
Ресей, Moscow; Moscow

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2. Fig. 1. Elution curve of 177Lu-bn without carrier and Yb with α-HIBA solution on a Dowex 50WX8 column.

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3. Fig. 2. Sorption of 177Lu-bn by TAN (a) and ok-TAN (b) samples, 100 μg/ml

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4. Fig. 3. Sorption of 177Lu-bn TAN and ox-TAN at pH 5.6 for 5 min depending on the m/V ratio.

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5. Fig. 4. Sorption of 177Lu-sn (20 ng) by TAN sample, 100 μg/ml.

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6. Fig. 5. Sorption of 177Lu-sn (20 ng) by STP (a) and ox-STP (b) samples, 100 μg/ml.

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7. Fig. 6. Sorption of 177Lu-sn (20 ng) by STP and ox-STP samples at pH 5.6 for 30 min depending on the m/V ratio.

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8. Fig. 7. Sorption of 177Lu-sn (300 ng) by ox-STP at pH 5.6 depending on the m/V ratio.

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