Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector9651510.17816/kazmj96515Research ArticleFunctional status of neutrophils and monocytes in rheumatoid arthritisArleevskayaM. I.info@eco-vector.comZinkevichO. D.info@eco-vector.comVoroninaI. E.info@eco-vector.comLenin Kazan Institute for Advanced Medical EducationKazan Research Institute of Epidemiology and Microbiology151019876853623641601202216012022Copyright © 1987, Eco-Vector1987<p>Phagocytes as an effector link of pathological immune reactions in rheumatoid arthritis, interacting with immune complexes, release into the environment lysosomal enzymes and oxygen radicals, which destroy synovial membrane and joint cartilage, which imparts autoantigenic properties to tissues. At the same time, neutrophils and monocytes phagocytize immune complexes and products of tissue destruction, contributing to their removal from the body. It can be assumed that in extra-articular manifestations of rheumatoid arthritis, when the above processes develop in other organs, blood phagocytes will be more active than in isolated joint syndrome.</p>Kazan Medical archiveКазанский медицинский архив