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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">96325</article-id><article-id pub-id-type="doi">10.17816/kazmj96325</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Theoretical and clinical medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Теоретическая и клиническая медицина</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Immunoglobulins E in the clinic and outcomes of viral hepatitis B in children with allergically altered reactivity</article-title><trans-title-group xml:lang="ru"><trans-title>Иммуноглобулины E в клинике и исходах вирусного гепатита B у детей с аллергически измененной реактивностью</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kalagina</surname><given-names>L. S.</given-names></name><name xml:lang="ru"><surname>Калагина</surname><given-names>Л. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Infectious Diseases, Department of Children's Infectious Diseases</p></bio><bio xml:lang="ru"><p>Кафедра инфекционных болезней, кафедра детских инфекционных болезней</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nagimova</surname><given-names>F. I.</given-names></name><name xml:lang="ru"><surname>Нагимова</surname><given-names>Ф. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Infectious Diseases, Department of Children's Infectious Diseases</p></bio><bio xml:lang="ru"><p>Кафедра инфекционных болезней, кафедра детских инфекционных болезней</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan Institute for the Improvement of Doctors named after V. I. Lenin</institution></aff><aff><institution xml:lang="ru">Казанский институт усовершенствования врачей имени В. И. Ленина</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Nizhny Novgorod Medical Institute named after S. M. Kirov</institution></aff><aff><institution xml:lang="ru">Нижегородский медицинский институт имени С. М. Кирова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Infectious Diseases Hospital No. 23</institution></aff><aff><institution xml:lang="ru">Инфекционная больница № 23</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1991-01-15" publication-format="electronic"><day>15</day><month>01</month><year>1991</year></pub-date><volume>72</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>28</fpage><lpage>30</lpage><history><date date-type="received" iso-8601-date="2022-01-13"><day>13</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-01-13"><day>13</day><month>01</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1991, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1991, Эко-Вектор</copyright-statement><copyright-year>1991</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/96325">https://kazanmedjournal.ru/kazanmedj/article/view/96325</self-uri><abstract xml:lang="en"><p>In 60 children aged 3 to 14 years old with viral hepatitis B, the clinical picture of the disease and the content of serum IgE were studied. In children with allergically altered reactivity, significantly increased and prolonged (more than 3 months) hyperimmunoglobulinemia E can be considered a prognostically unfavorable sign.</p></abstract><trans-abstract xml:lang="ru"><p>У 60 детей в возрасте от 3 до 14 лет, больных вирусным гепатитом B, изучены клиника заболевания и содержание сывороточных IgE. У детей с аллергически измененной реактивностью значительно повышенную и затяжную (более 3 мес) гипериммуноглобулинемию E можно считать прогностически неблагоприятным признаком.</p></trans-abstract><kwd-group xml:lang="en"><kwd>children</kwd><kwd>hepatitis B</kwd><kwd>serum immunoglobulins E</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>гепатит B</kwd><kwd>сывороточные иммуноглобулины E</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Блюгер А. Ф., Векслер Х. М., Крупникова Э. 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