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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">96224</article-id><article-id pub-id-type="doi">10.17816/kazmj96224</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Theoretical and clinical medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Теоретическая и клиническая медицина</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Experimental and clinical substantiation of the use of xymedon as an antioxidant in the complex treatment of patients with chronic osteomyelitis</article-title><trans-title-group xml:lang="ru"><trans-title>Экспериментально-клиническое обоснование использования ксимедона в качестве антиоксиданта в комплексном лечении больных хроническим остеомиелитом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malyshev</surname><given-names>K. V.</given-names></name><name xml:lang="ru"><surname>Малышев</surname><given-names>К. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution></institution></aff><pub-date date-type="pub" iso-8601-date="2000-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2000</year></pub-date><volume>81</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>13</fpage><lpage>17</lpage><history><date date-type="received" iso-8601-date="2022-01-12"><day>12</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-01-12"><day>12</day><month>01</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Эко-Вектор</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/96224">https://kazanmedjournal.ru/kazanmedj/article/view/96224</self-uri><abstract xml:lang="en"><p>The antioxidant activity of blood plasma is studied in patients with chronic osteomyelitis. The experimental data on the effect of antioxidants of xymedone and methyluracil on the basic free radicals, peroxide oxidation of li poids and chemoluminescence of peritoneal macrophages of rats made it possible to justify the use of drugs in the complex treatment of patients in pre- and postoperative period. As a result of the use of xymedone in the complex treatment the blood indices improved, antioxidant plasma activity increased in 25 patients of the basic group. In patients of the control group taking methyluracil the efficiency of the treatment was less significant</p></abstract><trans-abstract xml:lang="ru"><p>Лечение хронического остеомиелита (ХО), несмотря на достигнутые успехи, в медицинской практике остается сложным и недостаточно эффективным. По разным данным [4], у 13—65,7% пациентов возникают рецидивы заблевания, требующие длительного лечения и многократного проведения хирургических вмешательств.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Али-Заде Ч.А., Караваев Ч.Н., Пау кер А. В. и др.//Орчъпъ&amp;., травматол. — 1993. — № 3. — С. 100-102.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Бривиба К.К, Макарова Н.В., Тирзит Г.Д. Изд. Акад, наук Латвии. — Сер. “Химия”.—1989—№ 3.— С. 90-92.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Владимиров Ю.А., Азизова О.А., Деев А.И. и др. Свободные радикалы в живых системах. /ВИНИТИ, сер. “Биофизика”. — М., 1991.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Гостищев В. 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