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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">96137</article-id><article-id pub-id-type="doi">10.17816/kazmj96137</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Course and prognosis of nephrotic syndrome in children</article-title><trans-title-group xml:lang="ru"><trans-title>Течение и прогноз нефротического синдрома у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Makovetskaya</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Маковецкая</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kirichenko</surname><given-names>L. A.</given-names></name><name xml:lang="ru"><surname>Кириченко</surname><given-names>Л. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gusev</surname><given-names>Yu. P.</given-names></name><name xml:lang="ru"><surname>Гусев</surname><given-names>Ю. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rusakova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Русакова</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kuibyshev Ulyanov Medical Institute</institution></aff><aff><institution xml:lang="ru">Куйбышевский медицинский институт имени Д. И. Ульянова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Children's City Hospital No. 8</institution></aff><aff><institution xml:lang="ru">детская городская больница № 8</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1987-08-15" publication-format="electronic"><day>15</day><month>08</month><year>1987</year></pub-date><volume>68</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>281</fpage><lpage>284</lpage><history><date date-type="received" iso-8601-date="2022-01-09"><day>09</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-01-09"><day>09</day><month>01</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1987, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1987, Эко-Вектор</copyright-statement><copyright-year>1987</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/96137">https://kazanmedjournal.ru/kazanmedj/article/view/96137</self-uri><abstract xml:lang="en"><p>The development of nephrotic syndrome in a child poses diagnostic and therapeutic challenges to clinicians, such as clarifying the primary or secondary nature of the syndrome, determining its morphological basis if possible, developing treatment tactics during clinical observation and recommendations for supportive therapy in the outpatient setting. Although the clinical and laboratory complex of the nephrotic syndrome seems to be perfectly studied and the general principles of therapy are given in nephrology manuals, the prognosis of the disease still remains unclear; the tactics of supportive treatment need further development.</p></abstract><trans-abstract xml:lang="ru"><p>Развитие нефротического синдрома у ребенка ставит перед клиницистами такие задачи диагностического и лечебного плана, как выяснение первичности или вторичности синдрома с определением по возможности его морфологической основы, разработка лечебной тактики на этапе клинического наблюдения и рекомендаций в отношении поддерживающей терапии в амбулаторных условиях. Хотя клинико-лабораторный комплекс нефротического синдрома представляется идеально изученным и общие принципы терапии приведены в руководствах по нефрологии, прогноз заболевания до сих пор остается неясным; дальнейшей разработки требует и тактика поддерживающего лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Игнатова М. С//Педиатрия.— 1983.— № 3.— С. 61—66.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Игнатова М. С., Вельтищев Ю. Е.//Детская нефрология.— Л., Медицина, 1982.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Студеникин М. Я., ред. //Болезни почек в детском возрасте.— М., Медицина, 1976.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Cameron I. 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