Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector9080210.17816/kazmj90802Research ArticleBioquinol and blood enzymesNeshchadimenkoI.info@eco-vector.comGeneral Pathology Laboratory of Kyiv Medical Institute150619282465695722112202121122021Copyright © 1928, Eco-Vector1928<p>Salvarsan, introduced by Ehrlich in the therapy of syphilis, has revolutionized this field. This substance is known to have a strong spirillocidal effect, which is especially clear in vitro and in animal experiments. However, the use of salvarsan in humans was not as simple as in experimental animals, for clinical observations have shown that a single infusion of it is not enough - this on the one hand, and on the other hand - that its combination with other antisyphilitic agents is necessary. The best such combination is the combination of salvarsan with mercury, but even this combination has not proved to be quite effective, since some patients after its use began to show the side effects of mercury poisoning. These circumstances have forced researchers to look for new anti-syphilitic agents, which on the one hand would be effective against lues, and on the other hand, would be well tolerated by patients.</p>Kazan Medical archiveКазанский медицинский архив