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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">90147</article-id><article-id pub-id-type="doi">10.17816/kazmj90147</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The pathogenesis of polyuria in diabetes insipidus</article-title><trans-title-group xml:lang="ru"><trans-title>К патогенезу полиурии при diabetes insipidus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rakhlin</surname><given-names>L. M.</given-names></name><name xml:lang="ru"><surname>Рахлин</surname><given-names>Л. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Therapeutic Clinic of the State Institute for Advanced Medical Training</institution></aff><aff><institution xml:lang="ru">Терапевтическая клиника Гос. Института для усовершенствования врачей</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1928-02-15" publication-format="electronic"><day>15</day><month>02</month><year>1928</year></pub-date><volume>24</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>188</fpage><lpage>195</lpage><history><date date-type="received" iso-8601-date="2021-12-11"><day>11</day><month>12</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-12-11"><day>11</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1928, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1928, Эко-Вектор</copyright-statement><copyright-year>1928</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/90147">https://kazanmedjournal.ru/kazanmedj/article/view/90147</self-uri><abstract xml:lang="en"><p>Polyuria and associated polydipsia are known to be the main, and often the only, symptoms of diabetes insipidus. The amount of urine excreted may reach enormous figures - 43 liters in the case of Trousseau. Specific gravity is at a very low level, reaching 1001 and below. Together with this disturbance of water exchange, the exchange of sodium chloride is usually disturbed, and these two processes, in fact, characterize diabetes insipidus. Regarding the origin, systematics, and pathogenesis of these basic symptoms there is a large literature, but even on the main questions there are still fundamental discrepancies.</p></abstract><trans-abstract xml:lang="ru"><p>Полиурия и связанная с ней полидипсия представляют собой, как известно, главные, а часто и единственные симптомы diabetes insipidus. Количество выделяемой при этом мочи может доходить до громадных цифр—43 литра в случае Trousseau. Удельный вес стоит на очень низком уровне, доходя до 1001 и ниже. Вместе с этим нарушением водообмена бывает нарушен обычно и обмен хлористого натра, и эти два процесса, собственно говоря, и характеризуют собой diabetes insipidus. Относительно происхождения, систематики, патогенеза этих основных симптомов существует большая литература, но даже по главным вопросам здесь имеются до сих пор коренные расхождения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Проф. Д. М. Российский. Несахарный диабет. Изд. Практ. Мед., 1927.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Философов и Романенко. Рус. Клин., 1924, № 4.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Вакуленко. Врач. Газ., 1926, № 8—9.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Römer. Münch. med. 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