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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">89047</article-id><article-id pub-id-type="doi">10.17816/kazmj89047</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Theoretical and clinical medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Теоретическая и клиническая медицина</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Features of the clinical course of rheumatoid arthritis in women during pregnancy</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности клинического течения ревматоидного артрита у женщин в период беременности</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Davletshin</surname><given-names>R. A.</given-names></name><name xml:lang="ru"><surname>Давлетшин</surname><given-names>Р. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Therapy No. 1</p></bio><bio xml:lang="ru"><p>Кафедра терапии № 1</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Bashkir State Medical Institute named after the XѴth anniversary of the Komsomol</institution></aff><aff><institution xml:lang="ru">Башкирский государственный медицинский институт имени ХѴ-летия ВЛКСМ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1984-03-15" publication-format="electronic"><day>15</day><month>03</month><year>1984</year></pub-date><volume>65</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>128</fpage><lpage>130</lpage><history><date date-type="received" iso-8601-date="2021-11-25"><day>25</day><month>11</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-11-25"><day>25</day><month>11</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1984, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1984, Эко-Вектор</copyright-statement><copyright-year>1984</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/89047">https://kazanmedjournal.ru/kazanmedj/article/view/89047</self-uri><abstract xml:lang="en"><p>The study involved 52 women with rheumatoid arthritis, aged 18 to 29, including 19 pregnant women. The comparison of the clinical features of the process activity with the content of cortisol in the blood, anti-lymphocytic antibodies and rheumatoid factor was carried out. In women with rheumatoid arthritis, a decrease in the content of cortisol with a tendency to an increase in the titer of anti-lymphocyte antibodies and a significant increase in these indicators during pregnancy was found. Low cortisol levels were observed in the exacerbation phase of the rheumatoid process. The data obtained indicate the effect of the concentration of cortisol in the blood and the titer of anti-lymphocyte antibodies on the pathogenesis of rheumatoid arthritis, as well as the need to develop a tactic for treating women with this pathology.</p></abstract><trans-abstract xml:lang="ru"><p>Обследованы 52 женщины, больные ревматоидным артритом, в возрасте от 18 до 29 лет, в том числе 19 беременных. Проведено сопоставление клинических особенностей активности процесса с содержанием кортизола в крови, антилимфоцитарных антител и ревматоидного фактора. У женщин с ревматоидным артритом установлено снижение содержания кортизола при тенденции к росту титра антилимфоцитарных антител и значительное повышение этих показателей в период беременности. Низкий уровень кортизола наблюдался в фазе обострения ревматоидного процесса. Полученные данные свидетельствуют о влиянии концентрации кортизола в крови и титра антилимфоцитарных антител на патогенез ревматоидного артрита, а также о необходимости разработки тактики лечения женщин с данной патологией.</p></trans-abstract><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>pregnancy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>беременность</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Янбаева Х. И., Исаханов Г. 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