<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">86608</article-id><article-id pub-id-type="doi">10.17816/kazmj86608</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Pathogenetic therapy of acne vulgaris</article-title><trans-title-group xml:lang="ru"><trans-title>Патогенетическая терапия вульгарных угрей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Andreeva</surname><given-names>V. N.</given-names></name><name xml:lang="ru"><surname>Андреева</surname><given-names>В. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Dermatovenereology</p></bio><bio xml:lang="ru"><p>Кафедра дерматовенерологии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan State Institute for Advanced Training of Doctors named after V.I. Lenin</institution></aff><aff><institution xml:lang="ru">Казанский ГИДУВ им. В. И. Ленина</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1981-11-15" publication-format="electronic"><day>15</day><month>11</month><year>1981</year></pub-date><volume>62</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>44</fpage><lpage>46</lpage><history><date date-type="received" iso-8601-date="2021-11-03"><day>03</day><month>11</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-11-03"><day>03</day><month>11</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1981, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1981, Эко-Вектор</copyright-statement><copyright-year>1981</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/86608">https://kazanmedjournal.ru/kazanmedj/article/view/86608</self-uri><abstract xml:lang="en"><p>The pathogenetic substantiation of the effectiveness of the inclusion of zinc preparations in the complex of treatment of acne vulgaris is given. An original methodology for an objective assessment of the severity of skin manifestations of the process at the stages of treatment is presented. Based on the materials of examination and treatment of 34 patients with acne vulgaris, the initial change in the indicators of the activity of cellular alkaline phosphatase was proved, which stabilized during the course of treatment. The inclusion in the complex of therapy of the preparation of zinc sulfate in a dose of 110-220 mg contributed to the rapid disappearance of inflammation, a progressive decrease in the index of severity of skin manifestations and improvement of the immediate results of therapy.</p></abstract><trans-abstract xml:lang="ru"><p>Дано патогенетическое обоснование эффективности включения препаратов цинка в комплекс лечения вульгарных угрей. Приведена оригинальная методика, объективной оценки тяжести кожных проявлений процесса на этапах лечения. На материалах обследования и лечения 34 больных вульгарными угрями доказано исходное изменение показателей активности клеточной щелочной фосфатазы, стабилизирующееся, в ходе лечения. Включение в комплекс терапии препарата сульфата цинка в дозе 110— 220 мг способствовало быстрому исчезновению воспалительных явлений, прогрессивному снижению индекса тяжести кожных проявлений и улучшению ближайших результатов терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acne vulgaris</kwd><kwd>zinc</kwd><kwd>pathogenetic therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>вульгарные угри</kwd><kwd>цинк</kwd><kwd>патогенетическая терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Залем З. Я. Вести, дерматол., 1968, 7.—</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Ковтуняк Н. А., Ярмольчук Г. М. Научн. докл. высш. шк. Биол. науки, М., 1975, 1. —</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Леонов В. А., Дубина Т. Л. Цинк в организме человека и животных. Минск, 1971. —</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Солошенко Э. Н., Петрунин П. Ф. Вести, дерматол., 1977, 4. —</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Фракун В. Б. Врач, дело, 1966, 7; 1972, 6. —</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Beveridge G. W. Practitioner, 1970, 204, 1223 —</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Carruthers R. Healing. Drugs, 1973. 6, 3—4. —</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Cunliffe W. J., Chuster S Lancot, 1969, 1, 7597.-</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Demettris P. N. Ibid., 1972, 2, 1261. —</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Coolamali S. K., Comaish G. Ind J. Derm., 1975, 14, 3.—</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Frost P., Chen J., Rabbani J. a. o. In Line Metabolism, 1977.—</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Kirchner H., Rühle R. Lancet, 1973. 1, 1317. —</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Michael s son G., Juhlin L., Va hl gui st A. Arch. Dermatol., 1977, 113, 1.—</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Orris L., S h alita A. R., Sibulkin D. a. o. Ibid., 1978, 114, 7.—</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Raika G. Acta derm, vener., 1977, 57, 2—</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Smith J., B r o w n E., C a s s i b y W. In: Line metabolism, 1977.—</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Taylor M., King J. C., Tamura T. a o. Arch. Dermatol., 1978, 114, 7.—</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Weston W., Huff C. Ibid., 1977, 113, 422.’</mixed-citation></ref></ref-list></back></article>
