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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">84419</article-id><article-id pub-id-type="doi">10.17816/kazmj84419</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Efficiency of dimephosphone in sinus node weakness syndrome in children</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность димефосфона при синдроме слабости синусового узла у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Balykova</surname><given-names>L. A.</given-names></name><name xml:lang="ru"><surname>Балыкова</surname><given-names>Л. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Markelova</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Маркелова</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Balashov</surname><given-names>V. P.</given-names></name><name xml:lang="ru"><surname>Балашов</surname><given-names>В. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kotlyarov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Котляров</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Mordovian State University</institution></aff><aff><institution xml:lang="ru">Мордовский государственный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2001-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2001</year></pub-date><volume>82</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>424</fpage><lpage>427</lpage><history><date date-type="received" iso-8601-date="2021-10-31"><day>31</day><month>10</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-10-31"><day>31</day><month>10</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2001, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2001, Эко-Вектор</copyright-statement><copyright-year>2001</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/84419">https://kazanmedjournal.ru/kazanmedj/article/view/84419</self-uri><abstract xml:lang="en"><p>The comparative study of efficiency of dimephosphone (50—100 mg/kg/day intravenously in dropper) cytochrome c (0,5 mg/kg/day intravenously in dropper) and the standard treatment scheme in 121 children with sinus node weakness syndrome is carried out. It is shown that monotherapy with dimephosphone made it possible to reach the therapeutic effect in children with the I clinicoelectrocardiographic continuation of the disease. In the II and III types the addition of dimephosphone to the standard scheme increased its efficiency by 27—30%. The validity of continuation the neurometablic therapy with sinus node weakness syndrome during half a year and pe forming three courses of treatment with the drug at the interval of three months is shown.</p></abstract><trans-abstract xml:lang="ru"><p>Проведено сравнительное изучение эффективности димефосфона (50-100 мг/кг/сут внутривенно в капельнице) цитохрома с (0,5 мг/кг/сут внутривенно в капельнице) и стандартной схемы лечения у 121 ребенка с синдромом слабости синусового узла. Показано, что монотерапия димефосфоном позволила достичь терапевтического эффекта у детей с I клинико-электрокардиографическим продолжением заболевания. При II и III типах добавление димефосфона к стандартной схеме повышало ее эффективность на 27-30%. Показана обоснованность продолжения нейрометаболической терапии при синдроме слабости синусового узла в течение полугода и формирования трех курсов лечения препаратом с интервалом в три месяца.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Балыкова Л.А. 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