Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector840510.17816/KMJ2018-194Research ArticleConnective tissue dysplasia in females with primary knee and hip osteoarthritisIzmozherovaN Vnadezhda_izm@mail.ruGetmanovaN Anadezhda_izm@mail.ruPopovA Anadezhda_izm@mail.ruPeretolchinaT Fnadezhda_izm@mail.ruUral State Medical University1504201899219420030032018Copyright © 2018, Izmozherova N.V., Getmanova N.A., Popov A.A., Peretolchina T.F.2018<p><strong>Aim.</strong> Assessment of the prevalence of connective tissue dysplasia markers in women with primary knee and hip osteoarthritis.</p>
<p><strong>Methods.</strong> 203 females were examined in a cross-sectional study, with median age 58 years (55-62 years) and duration of post-menopause for 8 years (5.0-12.0 years). Severity of postmenopausal syndrome was defined by modified menopause index scores with the assessment of neurovegetative, metabolic and endocrine and psychoemotional symptoms. Backache and joint pain were assessed by visual analogue scale. Osteoarthritis was diagnosed according to clinical and radiologic criteria.</p>
<p><strong>Results.</strong> In 153 patients primary osteoarthritis stage 2-3 was diagnosed (group 1), group 2 included 50 patients without osteoarthritis. Screening for connective tissue dysplasia was performed by steps. At first, L.V. Solovyovas phenotypic screening scale modified by T.F. Peretolchina was used, and cut-off score of 1.92 points was found in 6 (12%) patients without osteoarthritis and 44 (28.8%) in osteoarthritis group, that allowed suggesting connective tissue dysplasia. Then international M.J. Glesby phenotypic scale was used: 53 (34.6%) patients with osteoarthritis and only 1 (2%) subject without osteoarthritis had three and more phenotypic traits (2=18.925, р 0.001), that confirms connective tissue dysplasia. On step three, according to Russian guidelines on Inherited disorders of connective tissue (Russian scientific society of cardiology, 2012), among examined patients three phenotypes of connective tissue dysplasia were determined: (1) joint hypermobility syndrome; (2) increased dysplastic stigmatization and (3) increased, mostly visceral dysplastic stigmatization. The latter was more prevalent in females with osteoarthritis.</p>
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