Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector7198010.17816/kazmj71980Research ArticleClinical and immunohistochemical assessment of proliferative activity in uterine myomaBorodinYu. I.info@eco-vector.comKiyasovA. P.info@eco-vector.comKlyucharovI. V.info@eco-vector.com15012001821384022062021Copyright © 2021, Borodin Y.I., Kiyasov A.P., Klyucharov I.V.2021<p>A tumor of the uterus, consisting of smooth muscles, is called myoma and fibroids, and in practice, the terms are used synonymously. Myoma of the uterus is a common disease in women of childbearing age. The frequency of its detection without regard to age is 2.45%. With age, its prevalence increases and reaches 8.31% by the age of 50. The estimate of the final probability of contracting uterine fibroids in the population throughout life is 9.7%. According to sectional data, uterine fibroids, including small nodes, occur in 20% of women. In 50% of cases, these tumors are manifested by clinically pronounced disorders that lead a woman to a doctor.</p>Kazan Medical archiveКазанский медицинский архив[БохманЯ.В., Ткешелашвили В.Г, Вишневский А. С., Волкова А.Т.Ц Акуш. и гин. — 1987. — № 7. — С. 12-16.][Вихляев а Е.М., Василевская Л. Н. Миома матки. — М., 1981.][Груздев В.С. Гинекология. — Казань, 1922.][Губарев А.П. Оперативная гинекология. — М., 1928.][Кленицкий Я.С. Фибромиома матки (гл. в книге: многотомное руководство по акушерству и гинекологии). — М., 1962.][Курбанова М.Х., Королева А.Г., Сергеева А. С./ /Генетика. - 1989. - № 10. - С. 1896-1898.][Савицкий ГА. Миома матки. — СПб, 1994.][Чакалова Г., Карагъозов А. И. др. //Вопр. он- кол. - 1991. - № 2. - С. 235-237.][Bacchi С.Е., Gown А.М.// Braz. J. Med. Biol. Res. — 1993.-Vol. 26.-P. 677-687.][Ch. Zaloudek et al. Mesenchimal tumours of the uterus from Blausteins Pathology of the Female Genital Tract. — 1995.][Downes K.A., Hart W.R.// Am. J. Surg. Pathol. — 1977.-Vol. 21,-P. 1261-1270.][Friedman A.J., Haas S.T.// Am. J. Obstet. Gynecol. - 1993. - Vol. 168. - P. 751-755. Am. J. Obstet Gynecol. — 1994. — Vol. 170. — P. 258—259.][Hall P.A. Assessment of cell proliferation markers with particular emphasis on Ki-67 and PCNA. A report for DAKO A/S. — London, 1993.][Martin H.// Zentralbl. Pathol. — 1994. — Vol. 140.-P. 15-22.][Poupeye E.M., Goethals P.P. е/д/.//Nucl. Med. Biol. - 1993. - Vol. 20. - P. 359-362.][Shi Y.F., Xie X., Zhao CL.// Chung. Hua. Fu. Chan. Ko. Tsa. Chih. - 1994. - Vol. 29. - P. 201-204,251.][Soumakis S., Panayiotides J. et al.// Eur. J. Gynecol. Oncol. — 1997. — Vol. 18. — P. 203—207.][Zaczek M., Dabros E., Maciejowski J., Szot W.// Patol. Pol. - 1994. - Vol. 45. - P. 35-38.]