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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">70742</article-id><article-id pub-id-type="doi">10.17816/kazmj70742</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Changes in extracellular cyclic nucleotides in patients with peptic ulcer disease and chronic gastritis</article-title><trans-title-group xml:lang="ru"><trans-title>Изменения внеклеточных циклических нуклеотидов у больных язвенной болезнью и хроническим гастритом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Trusov</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Трусов</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vakhrushev</surname><given-names>Ya. M.</given-names></name><name xml:lang="ru"><surname>Вахрушев</surname><given-names>Я. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ustinov Medical Institute</institution></aff><aff><institution xml:lang="ru">Устиновский ордена Дружбы народов медицинский институт</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1986-12-15" publication-format="electronic"><day>15</day><month>12</month><year>1986</year></pub-date><volume>67</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>401</fpage><lpage>403</lpage><history><date date-type="received" iso-8601-date="2021-05-17"><day>17</day><month>05</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-05-17"><day>17</day><month>05</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1986, Trusov V.V., Vakhrushev Y.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1986, Трусов В.В., Вахрушев Я.М.</copyright-statement><copyright-year>1986</copyright-year><copyright-holder xml:lang="en">Trusov V.V., Vakhrushev Y.M.</copyright-holder><copyright-holder xml:lang="ru">Трусов В.В., Вахрушев Я.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/70742">https://kazanmedjournal.ru/kazanmedj/article/view/70742</self-uri><abstract xml:lang="en"><p>The aim of this work was to study the peculiarities of changes in the levels of cyclic nucleotides (cAMP and cGMP) in peripheral blood during oral administration of solutions with different pH in patients with peptic ulcer disease and chronic gastritis. Studies were conducted in 55 patients, 23 of them had duodenal ulcer, 16 - chronic gastritis with decreased secretory function of the stomach.</p></abstract><trans-abstract xml:lang="ru"><p>Целью настоящей работы являлось изучение особенностей изменения уровня циклических нуклеотидов (цАМФ и цГМФ) в периферической крови при пероральном приеме растворов с различным pH у больных язвенной болезнью и хроническим гастритом. Исследования были проведены у 55 человек, из них у 23 больных была язвенная болезнь двенадцатиперстной кишки, у 16—хронический гастрит с пониженной секреторной функцией желудка.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>ЛИТЕРАТУРА</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Данченко А. П. 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