Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector701710.17750/KMJ2017-691Research ArticleHealth features of newborns depending on vitamin D level of their mothers during pregnancyVasil’evaE Ntomadenisova@rambler.ruMal’tsevaL Itomadenisova@rambler.ruDenisovaT Gtomadenisova@rambler.ruGerasimovaL Itomadenisova@rambler.ruChuvash State University named after I.N. UlyanovKazan State Medical AcademyPostgraduate Doctors’ Training Institute1510201798569169602102017Copyright © 2017, Vasil’eva E.N., Mal’tseva L.I., Denisova T.G., Gerasimova L.I.2017<p><strong>Aim.</strong> Evaluation of health state in newborns whose mothers were at risk of pre-eclampsia, depending on vitamin D level. </p>
<p><strong>Methods.</strong> Study materials included peripheral blood from pregnant women and umbilical cord blood of newborns. Vitamin D level was measured by enzyme-linked immunoassay kits of BIOMEDICAGRUPPE company (Germany). Intrauterine fetal state was studied with the use of ultrasonography. </p>
<p><strong>Results.</strong> Analysis of the study proved that vitamin D level in the umbilical cord blood correlates with its concentration in the mother’s blood. In women at pre-eclampsia risk decreased calcium level and vitamin D deficiency in the blood were detected. Administration of 2,000 IU of vitamin D and 1.5 g of calcium from the beginning of 2nd trimester of pregnancy resulted in reduction of frequency and severity of pre-eclampsia and its complications, including intrauterine growth retardation. Use of vitamin D in combination with calcium supplementation was shown to significantly improve unfavorable perinatal outcomes in women at high risk of pre-eclampsia, reducing by 3 times hypoxia and cerebral fetal lesions frequency that proves the vitamin D importance for functioning of mother-placenta-fetus system. </p>
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