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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">70092</article-id><article-id pub-id-type="doi">10.17816/kazmj70092</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Dynamics of immunologic parameters in elder children with atopic dermatitis</article-title><trans-title-group xml:lang="ru"><trans-title>Динамика иммунологических показателей у детей старшего возраста с атопическим дерматитом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamov</surname><given-names>В. А.</given-names></name><name xml:lang="ru"><surname>Шамов</surname><given-names>Б. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pediatric Diseases, Faculty of General Medicine, Department of Dermatovenereology</p></bio><bio xml:lang="ru"><p>Кафедра детских болезней лечебного факультета, Кафедра дерматовенерологии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamova</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Шамова</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Professor, Head of the Department of Children's Diseases, Faculty of General Medicine, Department of Dermatovenereology</p></bio><bio xml:lang="ru"><p>Профессор, заведующая кафедрой детских болезней лечебного факультета, Кафедра дерматовенерологии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Malanicheva</surname><given-names>T. G.</given-names></name><name xml:lang="ru"><surname>Маланичева</surname><given-names>Т. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department of Pediatric Diseases, Faculty of General Medicine, Department of Dermatovenereology</p></bio><bio xml:lang="ru"><p>Кафедра детских болезней лечебного факультета, Кафедра дерматовенерологии</p></bio><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan State Medical University</institution></aff><aff><institution xml:lang="ru">Казанский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1999-04-07" publication-format="electronic"><day>07</day><month>04</month><year>1999</year></pub-date><volume>80</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>253</fpage><lpage>255</lpage><history><date date-type="received" iso-8601-date="2021-04-30"><day>30</day><month>04</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1999, Shamov В.А., Shamova A.G., Malanicheva T.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1999, Шамов Б.А., Шамова А.Г., Маланичева Т.Г.</copyright-statement><copyright-year>1999</copyright-year><copyright-holder xml:lang="en">Shamov В.А., Shamova A.G., Malanicheva T.G.</copyright-holder><copyright-holder xml:lang="ru">Шамов Б.А., Шамова А.Г., Маланичева Т.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/70092">https://kazanmedjournal.ru/kazanmedj/article/view/70092</self-uri><abstract xml:lang="en"><p>In children aged 10 to 17 with atopic dermatitis the following changes are revealed: the decrease of the content of CD3+-cells, CD8+-cells, natural killers, CH50, the increase of immunoregulator index indicators, CD19+-cells, igg, ige circulating immune complexes. More pronounced disorders of the immune status are found in boys and girls aged 13 to 17 than in children aged 10 to 12. After the treatment the favourable dynamics of the indicators of CD8+-cells, immunoregulator index, concentration of igg, ige and circulating immune complexes is found.</p></abstract><trans-abstract xml:lang="ru"><p>Отличительной особенностью детей подросткового периода являются выраженная перестройка эндокринного аппарата, неравномерное развитие внутренних органов и систем организма, неоднозначные изменения иммунитета. Происходит критическая оценка окружающих, усиливается эмоциональное напряжение, изменяется возбудимость вегетативной нервной системы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kazan Medical archive</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Гребенюк ВН., Торопова Н.П., Кулагин В.И. 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