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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">653398</article-id><article-id pub-id-type="doi">10.17816/KMJ653398</article-id><article-id pub-id-type="edn">BONJXJ</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Approaches to Non-Pharmacological Modulation of Neural and Immune Communication: Therapeutic Potential of Vibration Stimulation</article-title><trans-title-group xml:lang="ru"><trans-title>Подходы к нефармакологической модуляции нервной и иммунной коммуникации: терапевтический потенциал вибрационной стимуляции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7670-6566</contrib-id><contrib-id contrib-id-type="scopus">35776847200</contrib-id><contrib-id contrib-id-type="spin">3939-3590</contrib-id><name-alternatives><name xml:lang="en"><surname>Shirolapov</surname><given-names>Igor V.</given-names></name><name xml:lang="ru"><surname>Широлапов</surname><given-names>Игорь Викторович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor, Head, Translational Research and Personalized Medicine Lab., Neurosciences Research Institute, Associate Professor, Depart. of Physiology</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент, заведующий, лаб. Трансляционных исследований и персонализированной медицины НИИ нейронаук, доцент, каф. физиологии</p></bio><email>ishirolapov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8055-1958</contrib-id><contrib-id contrib-id-type="spin">6326-6884</contrib-id><name-alternatives><name xml:lang="en"><surname>Pavlova</surname><given-names>Olga N.</given-names></name><name xml:lang="ru"><surname>Павлова</surname><given-names>Ольга Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Biology), Assistant Professor, Head, Depart. of Physiology</p></bio><bio xml:lang="ru"><p>доктор биологических наук, доцент, заведующий, каф. физиологии</p></bio><email>o.n.pavlova@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6338-7095</contrib-id><contrib-id contrib-id-type="spin">6795-5163</contrib-id><name-alternatives><name xml:lang="en"><surname>Gulenko</surname><given-names>Olga N.</given-names></name><name xml:lang="ru"><surname>Гуленко</surname><given-names>Ольга Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biology), Assistant Professor, Depart. of Physiology</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, доцент, каф. физиологии</p></bio><email>o.n.gulenko@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0666-7442</contrib-id><contrib-id contrib-id-type="spin">5788-5795</contrib-id><name-alternatives><name xml:lang="en"><surname>Moskvitina</surname><given-names>Polina M.</given-names></name><name xml:lang="ru"><surname>Москвитина</surname><given-names>Полина Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant Lecturer, Depart. of Physiology</p></bio><bio xml:lang="ru"><p>ассистент, каф. физиологии</p></bio><email>p.m.moskvitina@samsmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samara State Medical University</institution></aff><aff><institution xml:lang="ru">Самарский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-05-30" publication-format="electronic"><day>30</day><month>05</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2025</year></pub-date><volume>106</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>422</fpage><lpage>431</lpage><history><date date-type="received" iso-8601-date="2025-02-05"><day>05</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-02-27"><day>27</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-06-15"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/653398">https://kazanmedjournal.ru/kazanmedj/article/view/653398</self-uri><abstract xml:lang="en"><p>Nowadays, principles of neuromuscular system activation using vibration-mediated, intensive reflex stimulation are employed in addition to conventional physical activity for clinical rehabilitation or sports performance. Studies show that vibration training is an effective, non-pharmacological way to improve various body functions, which can effectively rehabilitate movement disorders and muscle weakness, as well as treat hormonal and metabolic disorders, osteoporosis, cardiorespiratory disorders, and age-related disorders. Immune dysfunction and age-related changes are closely associated with neuroinflammation and neurodegeneration. Recent data demonstrate the positive effects of vibration training on immune responses and higher integrative brain functions, suggesting a promising therapeutic approach for treating nervous system diseases. This article evaluates the effects of vibration training for neuromuscular stimulation on cellular and molecular pathways involved in neuroimmune communications and systematizes the available data on the potential use of this non-pharmacological option for treatment of neurological and immune disorders. Various vibration training programs demonstrate their effectiveness and multifunctional performance in treating deficits and could be a promising addition to conventional exercise and physical rehabilitation options. However, the effects of proprioceptive stimulation by vibration training on the nervous system and the associated immune response remain to be elucidated. Therefore, research in various animal models and in human, as well as a comprehensive evaluation of the results and therapeutic effectiveness, will contribute to a deeper, more systematic understanding of this technology's effects on human health.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящее время наряду с традиционной физической нагрузкой в целях клинической реабилитации или для достижения спортивных показателей применяются принципы активации нейромышечной системы с использованием рефлекторной интенсивной стимуляции, опосредованной вибрационным воздействием. В ряде исследований вибрационная физическая нагрузка как немедикаментозный метод воздействия на различные функциональные системы организма продемонстрировала свою эффективность в реабилитации двигательных расстройств и мышечной слабости, в коррекции гормональных и метаболических нарушений, остеопороза, кардиореспираторной и возраст-ассоциированной патологии. Иммунная дисфункция и возрастные изменения тесно коррелируют с процессами нейровоспаления и нейродегенерации. Последние данные указывают на положительное влияние вибрационного тренинга на иммунный ответ и высшие интегративные функции мозга, а также демонстрируют терапевтические возможности при заболеваниях нервной системы. В настоящей статье анализируется влияние вибрационной стимуляции нейромышечной системы на клеточные и молекулярные пути, вовлечённые в нейроиммунные коммуникации, и систематизированы имеющиеся данные о потенциале такого воздействия для немедикаментозной коррекции неврологических и иммунных нарушений. Анализ исходов различных программ вибрационной физической нагрузки подтверждает эффективность и многофункциональность данного вмешательства для коррекции соответствующего дефицита и позволяет рассматривать его как многообещающее дополнение к традиционным упражнениям и методам физической реабилитации. Однако вопросы о конкретных механизмах, посредством которых интенсивная проприоцептивная стимуляция в условиях вибрационного тренинга может влиять на различные аспекты функционирования нервной системы и иммунный ответ, остаются открытыми. Поэтому изучение данной технологии с помощью разнообразных модельных организмов и у человека, а также комплексное исследование результатов воздействия и всесторонняя оценка терапевтической эффективности будут способствовать более глубокому и системному пониманию особенностей её влияния на здоровье человека в целом.</p></trans-abstract><kwd-group xml:lang="en"><kwd>neuromuscular system</kwd><kwd>vibration stimulation</kwd><kwd>proprioception</kwd><kwd>neuroimmune interactions</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>нейромышечная система</kwd><kwd>вибрационная стимуляция</kwd><kwd>проприоцепция</kwd><kwd>нейроиммунные взаимодействия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Rittweger J. Manual of vibration exercise and vibration therapy. NYC, USA: Springer; 2020. 389 p. doi: 10.1007/978-3-030-43985-9</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Pyatin VF, Shirolapov IV. 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