<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">641804</article-id><article-id pub-id-type="doi">10.17816/KMJ641804</article-id><article-id pub-id-type="edn">FAOQQP</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Theoretical and clinical medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Теоретическая и клиническая медицина</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Evaluation of walking biomechanics in men with elemental imbalance</article-title><trans-title-group xml:lang="ru"><trans-title>Оценка биомеханических параметров ходьбы мужчин в условиях элементного дисбаланса</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>元素不平衡条件下男性行走的生物力学参数评估</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8297-931X</contrib-id><contrib-id contrib-id-type="spin">1647-5767</contrib-id><name-alternatives><name xml:lang="en"><surname>Ageenko</surname><given-names>Kirill I.</given-names></name><name xml:lang="ru"><surname>Агеенко</surname><given-names>Кирилл Игоревич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biology), Researcher, Head, Lab. of Bioelementology and Functional Morphology</p></bio><bio xml:lang="ru"><p>канд. биол. наук, заведующий, лаб. биоэлементологии и функциональной морфологии</p></bio><email>kir.ageenko@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6583-4175</contrib-id><contrib-id contrib-id-type="spin">5825-7122</contrib-id><name-alternatives><name xml:lang="en"><surname>Lugovaya</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Луговая</surname><given-names>Елена Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biology), Assistant Professor, Director</p></bio><bio xml:lang="ru"><p>канд. биол. наук, доцент, директор</p></bio><email>elena_plant@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8459-8473</contrib-id><name-alternatives><name xml:lang="en"><surname>Starenchenko</surname><given-names>Kirill A.</given-names></name><name xml:lang="ru"><surname>Старенченко</surname><given-names>Кирилл Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Junior Research Associate, Lab. of Bioelementology and Functional Morphology</p></bio><bio xml:lang="ru"><p>младший научный сотрудник, лаб. биоэлементологии и функциональной морфологии</p></bio><email>kirillstarenchenko@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">“Arctic” Research Center, Far Eastern Branch, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский центр «Арктика» Дальневосточного отделения Российской академии наук</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-07-03" publication-format="electronic"><day>03</day><month>07</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-08-05" publication-format="electronic"><day>05</day><month>08</month><year>2025</year></pub-date><volume>106</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>544</fpage><lpage>552</lpage><history><date date-type="received" iso-8601-date="2024-11-12"><day>12</day><month>11</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-12-28"><day>28</day><month>12</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-08-05"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://eco-vector.com/for_authors.php#07</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/641804">https://kazanmedjournal.ru/kazanmedj/article/view/641804</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND</bold><bold>:</bold> The analysis of walking biomechanics and macro- and micronutrient levels in participants based on contemporary measurement technologies allows for the assessment of the bioelemental bases of musculoskeletal functions.</p> <p><bold>AIM</bold><bold>:</bold> To establish the relationship between the temporal, phase, spatial, and kinematic parameters of walking in apparently healthy middle-aged men living in Magadan and the level of essential elements in their system.</p> <p><bold>METHODS</bold><bold>:</bold> Eighteen walking parameters of 42 apparently healthy middle-aged men were measured and assessed using a system for diagnosing musculoskeletal disorders and rehabilitation. The levels of 25 elements were determined in the hair of the participants using atomic emission and mass spectrometry with argon inductively coupled plasma. SPSS 23 software was used for statistical analysis. The Shapiro–Wilk test and Spearman rank correlation (<italic>p</italic> &lt; 0.05) were used.</p> <p><bold>RESULTS</bold><bold>:</bold> The temporal parameters of walking corresponded to the reference values in 73.81% to 100% of participants, the walking phase parameters in 76.19% to 92.86% of participants, and the spatial parameters in 76.19% to 100% of participants. The elemental profiles of the volunteers showed a deficiency of Ca (83.9%), Co (16.1%), Fe (16.1%), I (16.1%), Mg (22.6%), and Se (19.4%) and an excessive level of K (22.6%) and Na (12.9%). The concentration of these elements deviated from the reference values by a maximum of two times. Moderate positive (0.356 &lt; <italic>r</italic> &lt; 0.475; <italic>p</italic> &lt; 0.048) and negative (−0.472 &lt; <italic>r</italic> &lt; −0.382; <italic>p</italic> &lt; 0.034) correlations were detected between the walking biomechanics and Ca, Co, Cr, Fe, K, Mg, Na, P, Se, and Zn concentrations.</p> <p><bold>CONCLUSION</bold><bold>:</bold> The walking biomechanics of the examined apparently healthy Magadan residents corresponded to the reference ranges. A significant elemental imbalance (more than three times) leads to instrumental deviations of walking parameters.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Актуальность. </bold>Анализ биомеханических параметров ходьбы и уровней макро- и микроэлементов обследуемых, опирающийся на современные технологии их измерения, позволяет оценить биоэлементные основы функционирования опорно-двигательного аппарата.</p> <p><bold>Цель.</bold> Установить взаимосвязь временных, фазовых, пространственных и кинематических параметров ходьбы практически здоровых мужчин зрелого возраста, проживающих в г. Магадане, и содержания у них эссенциальных химических элементов.</p> <p><bold>Материал и методы.</bold> Измерение и оценку 18 параметров ходьбы у 42 практически здоровых мужчин зрелого возраста провели с помощью системы диагностики двигательной патологии и восстановительного лечения. Методами атомно-эмиссионной и масс-спектрометрии с индуктивно связанной аргоновой плазмой в волосах обследованных определили концентрации 25 химических элементов. Статистическую обработку выполнили с помощью программы SPSS 23. Применяли тест Шапиро–Уилка и ранговую корреляцию Спирмена (<italic>p</italic> &lt;0,05).</p> <p><bold>Результаты. </bold>Установлено, что временные параметры ходьбы соответствуют нормативным значениям у 73,81–100% обследованных, характеристики фаз ходьбы — у 76,19–92,86%, пространственные параметры — у 76,19–100% пациентов. Элементный профиль добровольцев характеризуется недостатком Ca (83,9%), Co (16,1%), Fe (16,1%), I (16,1%), Mg (22,6%), Se (19,4%) и избытком K (22,6%), Na (12,9%) при отклонении концентраций данных элементов от референсных значений не более чем в 2 раза. Умеренно выраженные положительные (0,356&lt; r &lt;0,475; <italic>p</italic> &lt;0,048) и отрицательные (−0,472&lt; r &lt;−0,382; <italic>p</italic> &lt;0,034) корреляционные связи были установлены между биомеханическими параметрами ходьбы и концентрациями Ca, Co, Cr, Fe, K, Mg, Na, P, Se, Zn.</p> <p><bold>Заключение.</bold> Биомеханические параметры ходьбы обследованных условно здоровых магаданцев соответствуют интервалам нормы. Значительный дисбаланс биоэлементов (более чем в 3 раза) приводит к инструментально фиксируемым отклонениям в параметрах ходьбы.</p></trans-abstract><trans-abstract xml:lang="zh"><p><bold>研究背景：</bold>基于现代测量技术，对行走的生物力学参数以及受试者的宏观和微观元素水平进行分析，可以评估肌肉骨骼系统功能的生物元素基础。</p> <p><bold>目的：</bold>建立生活在马加丹的实际健康成熟男性的时间，相位，空间和运动学行走参数与其基本化学元素含量之间的关系。研究对象与方法：使用用于诊断运动病理学和康复治疗的系统对42名实际健康的成熟年龄男性的18个行走参数进行了测量和评估。使用电感耦合氩等离子体的原子发射和质谱法测定受检患者头发中25种化学元素的浓度。使用SPSS 23程序进行统计处理。使用夏皮罗-威尔克检验和斯皮尔曼秩相关性（<italic>p</italic> &lt;0.05）。</p> <p><bold>结果：</bold>发现行走的时间参数对应于73.81-100％的检查患者的标准值，行走阶段的特征–在76.19-92.86％，空间参数—在76.19-100％的患者中。志愿者的元素分布特征在于缺乏Ca（83.9％）、Co（16.1％）、Fe（16.1％）、I（16.1％）、Mg（22.6％）、Se（19.4％）和过量的K（22.6％）、Na（12.9％）当这些元素的浓度偏离参考值不超过2倍。中度阳性（0.356&lt;<italic>r</italic> &lt;0.475；<italic>p</italic> &lt;0.048）和阴性（-0.472&lt;<italic>r</italic> &lt;-0.382； <italic>p</italic> &lt;0.034)建立了步行生物力学参数与Ca、Co、Cr、Fe、K、Mg、Na、P、Se、Zn浓度之间的相关性。</p> <p><bold>结论：</bold>被检查的条件健康马加丹居民的生物力学步行参数与正常间隔相对应。生物元素的显着不平衡（超过3倍）导致步行参数的仪器记录偏差。</p></trans-abstract><kwd-group xml:lang="en"><kwd>walking biomechanics</kwd><kwd>musculoskeletal system</kwd><kwd>essential chemical elements</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биомеханические параметры ходьбы</kwd><kwd>опорно-двигательная система</kwd><kwd>эссенциальные химические элементы</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>行走的生物力学参数</kwd><kwd>肌肉骨骼系统</kwd><kwd>基本化学元素</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Skvortsov DV. Diagnosis of motor pathology by instrumental methods: gait analysis, stabilometry. Moscow: Scientific-med. MBN company; 2007. (In Russ.) ISBN: 978-5-94982-045-2 EDN: QLQAIN</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Piche E, Gerus P, Chorin F, et al. The effect of different dual tasks conditions on gait kinematics and spatio-temporal walking parameters in older adults. Gait Posture. 2022;95:63–69. doi: 10.1016/j.gaitpost.2022.04.006 EDN: NCQBTS</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Herssens N, Verbecque E, Hallemans A, et al. Do spatiotemporal parameters and gait variability differ across the lifespan of healthy adults? A systematic review. Gait Posture. 2018;64:181–190. doi: 10.1016/j.gaitpost.2018.06.012</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Migel K, Wikstrom E. Gait biomechanics following taping and bracing in patients with chronic ankle instability: a critically appraised topic. J Sport Rehabil. 2020;29(3):373–376. doi: 10.1123/jsr.2019-0030 EDN: PERFPZ</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Koroleva SV. The technology of objective assessment of motor disorders in the dynamics of rehabilitation in patients with traumatic and orthopedic profile. Fizicheskaya i reabilitacionnaya medicina. 2022;4(1):47–52. doi: 10.26211/2658-4522-2022-4-1-47-52 EDN: ZCFJQS</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Kirpichev IV, Koroleva SV, Usmane MA. Study of the temporal characteristics of gaiting in patients with coxarthrosis. Fizicheskaya i reabilitacionnaya medicina. 2023;5(2):65–71. doi: 10.26211/2658-4522-2023-5-2-65-71 EDN: TSWVVZ</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Fukuchi CA, Fukuchi RK, Duarte M. Effects of walking speed on gait biomechanics in healthy participants: a systematic review and meta-analysis. Syst Rev. 2019;8(1):153. doi: 10.1186/s13643-019-1063-z EDN: UHLUIS</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Lau LK, Wee SL, Pang WJB, et al. Reference values of gait speed and gait spatiotemporal parameters for a south east asian population: the yishun study. Clin Interv Aging. 2020;15:1753–1765. doi: 10.2147/CIA.S270407</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lordall J, Oates AR, Lanovaz JL. Spatiotemporal walking performance in different settings: effects of walking speed and sex. Front Sports Act Living. 2024;6:1277–1587. doi: 10.3389/fspor.2024.1277587 EDN: TPKSOV</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Rössler R, Wagner J, Knaier R, et al. Spatiotemporal gait characteristics across the adult lifespan: reference values from a healthy population — analysis of the COmPLETE cohort study. Gait Posture. 2024;109:101–108. doi: 10.1016/j.gaitpost.2024.01.005 EDN: GNIWXK</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Ciosek Ż, Kot K, Kosik-Bogacka D, et al. The effects of calcium, magnesium, phosphorus, fluoride, and lead on bone tissue. Biomolecules. 2021;11(4):506. doi: 10.3390/biom11040506 EDN: JGLSCN</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Danilchenko S, Rogulsky Y, Kulik A, et al. A simple method to determine the fractions of labile and mineral-bound microelements in bone tissue by atomic absorption spectrometry. Biol Trace Elem Res. 2021;199(3):935–943. doi: 10.1007/s12011-020-02234-4 EDN: MHGLFU</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Shrimanker I, Bhattarai S. Electrolytes. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. 2023 Jul 24.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Gorbachev AL, Efimova AV, Lugovaya EA, Bulban AP. Features of element's status of inhabitants of different natural-geographic territories of the Magadan region. Human ecology. 2003;6:12–16. EDN: HRTKUV</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lugovaya EA, Stepanova EM. Regional indicators of the content of macro- and microelements in the body of residents of Magadan. Scientific and practical recommendations. Magadan: Ekspress-poligrafiya; 2019. (In Russ.)</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Skalny AV, Grabeklis AR, Korobejnikova TV, et al. Reference values of the content of chemical elements in human biological substrates. Мoscow, 2023. 58 p. (In Russ.)</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Lugovaya EA, Stepanova EM. Analisys of elemental status of residents of Magadan town with different body mass index. Part 2. Element interconnections. Problems of biological, medical and pharmaceutical chemistry. 2014;11:66–71. EDN: TEQRVH</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Rondanelli M, Faliva MA, Tartara A, et al. An update on magnesium and bone health. Biometals. 2021;34(4):715–736. doi: 10.1007/s10534-021-00305-0 EDN: SCATRA</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Pinto MM, Dubouchaud H, Jouve C, et al. A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles. J Physiol Biochem. 2022;78(2):501–516. doi: 10.1007/s13105-021-00827-8 EDN: KQJPFS</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Zhao J, Lu Q, Zhang X. Associations of serum vitamin B12 and its biomarkers with musculoskeletal health in middle-aged and older adults. Front Endocrinol. 2024;15:1387035. doi: 10.3389/fendo.2024.1387035 EDN: KPZWJU</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Pyrgioti EE, Karakousis ND. B12 levels and frailty syndrome. J Frailty Sarcopenia Falls. 2022;7(1):32–37. doi: 10.22540/JFSF-07-032 EDN: BQOBZQ</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Swart KM, van Schoor NM, Lips P. Vitamin B12, folic acid, and bone. Curr Osteoporos Rep. 2013;11(3):213–218. doi: 10.1007/s11914-013-0155-2 EDN: CAAIWC</mixed-citation></ref></ref-list></back></article>
