Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector6303210.17816/kazmj63032Research ArticleDiagnostic value of the determination of cortisol and its metabolites in the urine of patients with Itsenko-Cushing's diseaseKalininA. P.info@eco-vector.comNarujnukN. D.info@eco-vector.comКазанскаяG. A.info@eco-vector.comLabor Research Clinical Institute. M.F. Vladimirsky3107197455450511003202110032021Copyright © 1974, Kalinin A.P., Narujnuk N.D., Казанская G.A.1974<p>It has been established that in Itsenko-Cushing's disease, the main clinical manifestations of the disease arise as a result of excessive production of adrenal cortex hormones, mainly glucocorticoids.</p>Kazan Medical archiveКазанский медицинский архив