Kazan medical journalKazan medical journalКазанский медицинский журнал0368-48142587-9359Eco-Vector60741910.17816/KMJ607419ReviewsОбзорыReview ArticleSERPINE-1 gene polymorphism in patients with cardiovascular diseasesПолиморфизм гена SERPINE-1 у пациентов с сердечно-сосудистыми заболеваниямиhttps://orcid.org/0000-0001-8850-1843UsmanovaAigul F.УсмановаАйгуль Фаритовна
Russian Federation

Postgrad. Stud., Hospital Therapy Department

асп., каф. госпитальной терапии

Y.Aigul5543823@yandex.ruhttps://orcid.org/0000-0001-6701-5395MayanskayaSvetlana D.МаянскаяСветлана Дмитриевна
Russian Federation

M.D., D. Sci. (Med.), Prof., Hospital Therapy Depart.

докт. мед. наук, проф., каф. госпитальной терапии

Smayanskaya@mail.ruhttps://orcid.org/0000-0002-4227-008XKravtsovaOlga A.КравцоваОльга Александровна
Russian Federation

Cand. Sci. (Biol.), Assoc. Prof., Depart. of Biochemistry, Biotechnology and Pharmacology

канд. биол. наук, доц., каф. биохимии, биотехнологии и фармакологии

okravz@yandex.ruKazan State Medical UniversityКазанский государственный медицинский университетKazan State Medical UniversityКазанский государственный медицинский университетKazan (Volga Region) Federal UniversityКазанский (Приволжский) федеральный университет190220240104202410522722831010202309112023Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttp://creativecommons.org/licenses/by-nc-sa/4.0https://kazanmedjournal.ru/kazanmedj/article/view/607419

Currently, the issues of recurrent course of cardiovascular diseases are given great importance. Today, there is a search for more and more new factors and causes, including genetic ones, that contribute to the increase in the incidence of circulatory system diseases. The study of polymorphic variants of hemostasis system genes made it possible to study the molecular mechanisms underlying the causes of cardiovascular complications. Polymorphism of the SERPINE-1 gene, encoding plasminogen activator inhibitor-1, is associated with the occurrence of cardiovascular diseases. This literature review examines the influence of SERPINE-1 gene polymorphism and the concentration of the plasminogen activator inhibitor-1 it encodes on the development and severity of circulatory system diseases; as well as the role of plasminogen activator inhibitor-1 as one of the indicators reflecting the antifibrinolytic potential of the blood. Taking into account the opinion of most authors, we can conclude that the polymorphism of the SERPINE-1 gene and its homozygous variant 4G/4G, due to which the synthesis of plasminogen activator inhibitor-1 is increased, is an unfavorable predictor of many pathological processes. However, most of the data have been obtained on the association of the SERPINE-1 gene polymorphism with cardiovascular diseases, where, according to most authors, the 4G/4G genotype is a prognostically negative variant. However, a number of researchers believe that the heterozygous 5G/4G variant is likely associated with the occurrence of cerebral ischemia. The inconsistency of the data obtained, of course, requires further study of the characteristics of the SERPINE-1 gene polymorphism in various pathological conditions, which is an important prerequisite for understanding the mechanisms of a number of diseases. To prepare the review, a literature search method in PubMed databases for the period 2013–2023 was used.

В настоящее время вопросам рецидивирующего течения сердечно-сосудистых заболеваний придают большое значение. На сегодняшний день идёт поиск всё более новых факторов и причин, в том числе генетических, способствующих росту частоты болезней системы кровообращения. Исследование полиморфных вариантов генов системы гемостаза позволило изучить молекулярные механизмы, лежащие в основе причин сердечно-сосудистых осложнений. Полиморфизм гена SERPINE-1, кодирующего ингибитор активатора плазминогена-1, ассоциирован с возникновением сердечно-сосудистых заболеваний. В данном литературном обзоре рассмотрено влияние полиморфизма гена SERPINE-1 и концентрации кодируемого им ингибитора активатора плазминогена-1 на развитие и тяжесть течения болезней системы кровообращения; а также роль ингибитора активатора плазминогена-1 как одного из показателей, отражающих антифибринолитический потенциал крови. Принимая во внимание мнение большинства авторов, можно сделать вывод о том, что полиморфизм гена SERPINE-1 и его гомозиготный вариант 4G/4G, за счёт которого увеличен синтез ингибитора активатора плазминогена-1, — неблагоприятный предиктор многих патологических процессов. Однако больше всего данных получено по ассоциации полиморфизма гена SERPINE-1 с сердечно-сосудистыми заболеваниями, где, по мнению большинства авторов, генотип 4G/4G представляет собой прогностически негативный вариант. Тем не менее, ряд исследователей считают, что гетерозиготный вариант 5G/4G, вероятно, связан с возникновением церебральной ишемии. Противоречивость полученных данных, безусловно, требует дальнейшего изучения особенностей полиморфизма гена SERPINE-1 при различных патологических состояниях, что является важной предпосылкой к пониманию механизмов течения ряда заболеваний. При подготовке обзора был использован метод поиска литературы по базам данных PubMed за период 2013–2023 гг.

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