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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">60722</article-id><article-id pub-id-type="doi">10.17816/kazmj60722</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical and immunological aspects of the spa treatment of patients with rheumatoid arthritis</article-title><trans-title-group xml:lang="ru"><trans-title>Клинико-иммунологические аспекты курортного лечения больных ревматоидным артритом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Trofimova</surname><given-names>R. I.</given-names></name><name xml:lang="ru"><surname>Трофимова</surname><given-names>Р. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Department of Pathological Physiology of the Kazan State Pedagogical University named after V.I. Lenin and the immune-allergological laboratory of the Slavyansky resort</institution></aff><aff><institution xml:lang="ru">Кафедра патологической физиологии Казанского ГИДУВа им. В. И. Ленина и иммунно-аллергологическая лаборатория Славянского курорта</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1982-04-15" publication-format="electronic"><day>15</day><month>04</month><year>1982</year></pub-date><volume>63</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>33</fpage><lpage>35</lpage><history><date date-type="received" iso-8601-date="2021-02-12"><day>12</day><month>02</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-02-12"><day>12</day><month>02</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1982, Trofimova R.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1982, Трофимова Р.И.</copyright-statement><copyright-year>1982</copyright-year><copyright-holder xml:lang="en">Trofimova R.I.</copyright-holder><copyright-holder xml:lang="ru">Трофимова Р.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/60722">https://kazanmedjournal.ru/kazanmedj/article/view/60722</self-uri><abstract xml:lang="en"><p>The parameters of cellular and humoral immunity were studied in 160 patients with rheumatoid arthritis. Immunodeficiency of T-lymphocytes was found in 41% of patients with minimal and in 67% of patients with an average degree of activity of rheumatoid arthritis, on the basis of which various complexes of spa treatment of this disease were developed.</p></abstract><trans-abstract xml:lang="ru"><p>Изучены показатели клеточного и гуморального иммунитета у '160 больных ревматоидным артритом. Обнаружен иммунодефицит Т-лимфоцитов у 41% больных с минимальной и у 67% больных со средней степенью активности ревматоидного артрита, на основании чего разработаны различные комплексы курортного лечения этого заболевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>immunological methods for studying the activity of the process</kwd><kwd>spa treatment</kwd><kwd>Kazan Medical archiv</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>иммунологические методы исследования активности процесса</kwd><kwd>курортное лечение</kwd><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Арустамова Р. Г., Болотин Е. В., Гордовская И. Б. Тер. арх.,1976,8.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Буланова Т. Д., Полянская И. П., Чибисова В. А. 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