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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">60567</article-id><article-id pub-id-type="doi">10.17816/kazmj60567</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The effectiveness of differentiated treatment of patients with essential hypertension</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность дифференцированного лечения больных гипертонической болезнью</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Panfilov</surname><given-names>Yu. A.</given-names></name><name xml:lang="ru"><surname>Панфилов</surname><given-names>Ю. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kryukov</surname><given-names>N. N.</given-names></name><name xml:lang="ru"><surname>Крюков</surname><given-names>Н. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baibursyan</surname><given-names>E. D.</given-names></name><name xml:lang="ru"><surname>Байбурсян</surname><given-names>Е. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>info@eco-vector.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Department of Internal Diseases of the Dental and Pediatric Faculties of the Kuibyshev Medical Institute named after D. I. Ulyanova</institution></aff><aff><institution xml:lang="ru">Кафедра внутренних болезней стоматологического и педиатрического факультетов Куйбышевского медицинского института им. Д. И. Ульянова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="1982-04-15" publication-format="electronic"><day>15</day><month>04</month><year>1982</year></pub-date><volume>63</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>19</fpage><lpage>21</lpage><history><date date-type="received" iso-8601-date="2021-02-10"><day>10</day><month>02</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-02-10"><day>10</day><month>02</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1982, Panfilov Y.A., Kryukov N.N., Baibursyan E.D.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1982, Панфилов Ю.А., Крюков Н.Н., Байбурсян Е.Д.</copyright-statement><copyright-year>1982</copyright-year><copyright-holder xml:lang="en">Panfilov Y.A., Kryukov N.N., Baibursyan E.D.</copyright-holder><copyright-holder xml:lang="ru">Панфилов Ю.А., Крюков Н.Н., Байбурсян Е.Д.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/60567">https://kazanmedjournal.ru/kazanmedj/article/view/60567</self-uri><abstract xml:lang="en"><p>Abstract. Depending on the hemodynamic type and state of the kallikreinkinin 'blood system, differential treatment of 246 hypertensive patients was carried out using the beta-blocker anaprilin and the peripheral arteriolar vasodilator apressin. A pronounced hypotensive effect was observed in 82.5% of patients. In patients who underwent differential treatment, a decrease in blood pressure was observed 3.2 days earlier than in patients who were treated empirically; hospitalization terms were reduced by an average of 2.5 bed-days.</p></abstract><trans-abstract xml:lang="ru"><p>Реферат. В зависимости от гемодинамического типа и состояния калликреин- кининовой' системы крови проводилось дифференцированное лечение 246 больных гипертонической болезнью с применением бета-блокатора анаприлина и периферического артериолярного вазодилататора апрессина. Выраженный гипотензивный эффект отмечен у 82,5% больных. У пациентов, подвергшихся дифференцированному лечению, снижение артериального давления наблюдалось на 3,2 дня раньше, чем у больных, лечение которых осуществлялось эмпирически; сроки госпитализации сократились в среднем на 2,5 койко-дня.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hypertonic disease</kwd><kwd>anaprilin</kwd><kwd>apressin</kwd><kwd>Kazan Medical archiv</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гипертоническая болезнь</kwd><kwd>анаприлин</kwd><kwd>апрессин</kwd><kwd>Казанский медицинский архив</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Волков В. С., Высоцкий Н. Н., Троцюк В. В., Мишин В. И. .Клин. &amp;(ед., 1976, 7.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Куница Л. Д. Там же, 1979, 7.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Кутаковский М. С. Гипертоническая болезнь. 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