Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector563810.17750/KMJ2016-887Research ArticleFeatures of drug therapy for patients with myocardial infarction and different glomerular filtration ratesBelkoreyO Scardiosvao@gmail.comD’yakovaE Ncardiosvao@gmail.comOslopovV Ncardiosvao@gmail.comKhasanovN Rcardiosvao@gmail.comCity Polyclinic №218Healthcare Department of North-Eastern Administrative DistrictKazan State Medical University1512201697688789218112016Copyright © 2016, Belkorey O.S., D’yakova E.N., Oslopov V.N., Khasanov N.R.2016<p><strong>Aim.</strong> To study the features of treatment of patients with myocardial infarction and different functional state of kidneys at outpatient and inpatient stages of treatment.</p><p><strong>Methods.</strong>A retrospective study included 179 patients admitted to the hospitals of Moscow North-Eastern Administrative District with verified diagnosis of myocardial infarction. Depending on glomerular filtration rate all patients were divided into two groups: patients with acute myocardial infarction and with GFR of ≥60 ml/min/1.73 m2, and those with GFR</p><p><strong>Results.</strong> Prevalence of arterial hypertension among patients with decreased functional state of kidneys was 94.5% vs. 76.8% among patients with preserved kidney function (p=0.004), prevalence of ischemic heart disease was 36.4% vs. 18.8% respectively (p=0.021). Outpatients administration rate of ACE inhibitors to patients with decreased kidney function was 18.2% and that of statins was 1.8%. Among patients with history of myocardial infarction 24.4% received aspirin, and 35.6% received another antithrombotic medication (P2Y12 platelet receptor inhibitor).</p><p><strong>Conclusions.</strong> Arterial hypertension and history of myocardial infarction, prolonged inpatient stay were observed more frequently in patients with decreased kidney function; outpatient administration of ACE inhibitors, statins and antithrombotic medications to patients with history of myocardial infarction and decreased kidney functional ability was rare.</p>myocardial infarctionchronic kidney diseasedrug therapyинфаркт миокардахроническая болезнь почеклекарственная терапия[Концепция долгосрочного социально-экономического развития Российской Федерации на период до 2020 г. Распоряжение Правительства РФ. 2008; 1662-р.][Моисеев В.С., Мухин Н.А., Смирнов А.В. Клинические рекомендации. Сердечно-сосудистый риск и хроническая болезнь почек: стратегии кардионефропротекции. Рос. кардиол. ж. 2014; 8 (112): 7-37.][Эрлих А.Д., Грацианский Н.А. Российский регистр острого коронарного синдрома «РЕКОРД-3». Характеристика пациентов и лечение до выписки из стационара. Кардиология. 2016; (4): 16-24.][Avezum A., Makdisse M., Spencer F. et al. Impact of age on management and outcome of acute coronary syndrome: observations from the Gloal Registry of Acute Coronary Events (GRACE). Am. Heart J. Jan. 2005; 149 (1): 67-73. http://dx.doi.org/10.1016/j.ahj.2004.06.003][Culleton B.F., Larson M.G., Wilson P.W. et al. Cardiovascular disease and mortality in a community-based cohort with mild renal insuffiency. Kidney Int. 1999; 56: 2214-2219. http://dx.doi.org/10.1046/j.1523-1755.1999.00773.x][Hamm C.W., Ardissino D., Boersma E. et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. The task force for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes of the European Society of Cardiology. Eur. Heart J. 2007; 28: 1598-1660. http://dx.doi.org/10.1093/eurheartj/ehm161][Lea J.P., Greene E.L., Nicholas S.B. et al. Cardiorenal metabolic syndrome in the African diaspora: rationale for including chronic kidney disease in the metabolic syndrome definition. Ethn. Dis. 2009; 19 (Suppl. 2): 11-14.][McCullough P.A., Li S., Jurkovitz C.T. et al. CKD and cardiovascular disease in screened high-risk volunteer and general populations: the Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999-2004. Am. J. Kidney Dis. 2008; 51 (4, suppl. 2): 38-45. http://dx.doi.org/10.1053/j.ajkd.2007.12.017][Peterson E.D., Roe M.T., Mulgund J. et al. Association between hospital process performance and outcomes among patients with acute coronary syndromes. JAMA. 2006; 295 (16): 1912-1920. http://dx.doi.org/10.1001/jama.295.16.1912][Thom T., Haase N., Rosamond W. et al. Heart disease and stroke statistics - 2006 update: report from American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006; 113 (6): 85-151. http://dx.doi.org/10.1161/CIRCULATIONAHA.105.171600]