Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector3342810.17816/KMJ2020-574Research ArticleA clinical case of central cancer of the lung and infiltrative tuberculosisNaumovA Gnaumovag@pimunn.ruPavluninA Vnaumovag@pimunn.ruGolovaA Yunaumovag@pimunn.ruNikolskayaN Anaumovag@pimunn.ruMansurskayaK Vnaumovag@pimunn.ruSamarinaO Enaumovag@pimunn.ruPrivolzhsky Research Medical University1208202010145745781304202018062020Copyright © 2020, Naumov A.G., Pavlunin A.V., Golova A.Y., Nikolskaya N.A., Mansurskaya K.V., Samarina O.E.2020<p>The scientific challenge of combining the tuberculosis process and lung cancer has not been fully disclosed in modern literature. This primarily involves the low incidence of these two pathologies at the same time. This may contribute to difficulties in the qualitative and timely diagnosis of these diseases. Tuberculosis hides the radiological manifestations of a malignant tumor for a long time that contributing to its progression and the development of high mortality among patients. Lung cancer facilitates hemato- and lymphogenous spread of a specific pathogen. As an example, a clinical case of simultaneous occurrence of pulmonary tuberculosis and lung cancer which was observed in the patient admitted to the Department for patients with respiratory tuberculosis of Nizhny Novgorod regional clinical tuberculosis dispensary, was presented. We concluded that compliance with the algorithm of the mandatory diagnostic minimum when patients admitted to the general healthcare network, as well as compliance with the rules for population screening, especially among people over 45, will minimize the risks of delayed diagnosis in case of coexistence of respiratory tuberculosis and lung cancer.</p>tuberculosislung cancercombinationdiagnosisтуберкулёзрак лёгкогосочетаниедиагностика[Global tuberculosis report 2019. Geneva: World Health Organization. 2019; 283 p.][Ergeshov A.E. Tuberculosis in the Russian Federation: situation, challenges and perspectives Vestnik RAMN. 2018; 73 (5): 330–337. (In Russ.) DOI: 10.15690/vramn1023.][Nechaeva O.B. Socially important infectious diseases posing a biological threat to the population of Russia. Tuberculosis and lung diseases. 2019; 97 (11): 7–17. (In Russ.) DOI: 10.21292/2075-1230-2019-97-11-7-17.][Silva D.R., Valentini D.F., Borges de Almeida C.P., Dalcin P. de Tarso R. Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence. J. Bras. Pneumol. 2013; 39 (4): 484–489. DOI: 10.1590/S1806-37132013000400013.][Roca I., Akova M., Baquero F. et al. The goal threat of antimicrobial resistance: science for intervention. New Microbes New Infect. 2015; 6: 22–29. DOI: 10.1016/j.nmni.2015.02.007.][Furin J., Brigden G., Lessem E. et al. Global progress and challenges in implementing new medications for treating multidrug-resistant tuberculosis. Emerg. Infect. Dis. 2016; 22 (3): e151430. DOI: 10.3201/eid2203.151430.][Karashchuk N.P., Kiseleva M.V. Cancer and tuberculosis of the lung. Nauchnyy meditsinskiy vestnik Yugry. 2014; (1–2): 71–73. (In Russ.)][Polyanskiy V.K., Savitskiy G.G., Lyatoshinskiy A.V. Lung cancer in patients with tuberculosis. Tuberkulez i sotsial'no-znachimye zabolevaniya. 2015; (3): 81–82. (In Russ.)][Belova O.S., Komarov I.G. Differential diagnosis of lung cancer and tuberculosis: review. Sovremennaya onkologiya. 2018; (3): 56–61. (In Russ.)][Cuéllar L., Carstaneda A.C., Rojas K. et al. Característicasclínicas y toxicidad del tratamiento de tuberculosis enpacientes con cancer. Rev. Peru Med. Exp. Salud Publica. 2015; 32: 272–277.][Plotnikov V.P., Perminova I.V., Chernykh E.E., Laptev S.P. A case of concurrent lung cancer and fibrous-cavernous pulmonary tuberculosis. Tuberculosis and lung diseases. 2019; 97 (1): 35–40. (In Russ.) DOI: 10.21292/2075-1230-2019-97-1-35-40.][Cukic V. The association between lung carcinoma and tuberculosis. Med. Arch. 2017; 73 (3): 212–214. DOI: 10.5455/medarh.2017.71.212-214.]