Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector211910.17816/KMJ2119Research ArticleElectrophysiological parameters in patients with the «dry» form of age-related macular degeneration treated with polarized polychromatic non-coherent light and dynamic electromyostimulationSaifullinaF R-SharafievaR Zrezinshar@rambler.ruPogorel’tsevV I-AbdulaevaE A-Kazan State Medical Academy, Kazan, RussiaOut-patients Clinic of Kazan Scientific Centre of Russian Academy of Science, Kazan, RussiaKazan State Medical University, Kazan, Russia1512201293696196528032016Copyright © 2012, Saifullina F.R., Sharafieva R.Z., Pogorel’tsev V.I., Abdulaeva E.A.2012Aim. To study the electrophysiological parameters in patients with the «dry» form of age-related macular degeneration before and after combined treatment with polarized polychromatic non-coherent light and dynamic electromyostimulation. Methods. Two groups of patients with the «dry» form of age-related macular degeneration were examined. Patients in the main group (40 patients, 80 eyes) were treated with a combination of polarized polychromatic non-coherent light and dynamic electromyostimulation, patients in the control group (39 patients, 78 eyes) were treated conventionally. Mean age of the patients was 71.3±1.1 years. All patients underwent standard ophthalmic examination. To assess the functional status of the macula, electroretinography was performed using the «Neuro-MVP» device (Ivanovo, Russia). A-wave amplitude and latency on the red light stimulus were examined. Results. A-wave amplitude on macular electroretinogram was 11.9% lower and A-wave latency was 20.8% higher in patients with age-related macular degeneration compared to healthy subjects. A statistically significant improvement of the A-wave amplitude and latency was observed on macular electroretinogram after the combined treatment. A-wave amplitude increased from 13.22±1.36 to 17.17±1.59 µV (p 0.01) after 2 months and up to 17.80±1.60 µV (p 0.05) after 6 months of treatment. A-wave latency decreased from 19.32±0.41 to 18.51±0.36 ms (p 0.01) after 2 months and down to 18.31±0.45 ms (p 0.05) after 6 months of treatment. There was a relevant increase in A-wave amplitude from 13.15±1.09 to 16.3±1.09 µV (p 0.01) and decrease in A-wave latency from 19.23±0.30 to 18.64±0.30 ms (p 0.05) in patients of the control group 2 months after the end of treatment. Conclusion. There were relevant increase in A-wave amplitude and decrease in A-wave latency observed on macular electroretinography after treatment. The proposed treatment method does not cause any complications and can be used as a treatment option in patients with allergic reactions to standard drugs.age-related macular degeneration«dry» formelectroretinographyvisual evoked potentialvertebrobasilar systemcerebral hemodynamicsвозрастная макулярная дегенерациясухая формаэлектроретинографиязрительные вызванные потенциалы на паттернвертебробазилярный бассейнцеребральная гемодинамика[Аветисов С.Э., Киселёва Т.Н., Лагутина Ю.М., Кравчук Е.А. Влияние вазоактивных препаратов на зрительные функции и глазной кровоток у больных с ранними проявлениями возрастной макулярной дегенерации // Вестн. офтальм. - 2007. - Т. 123, №3. - С. 1-4.][Журавлёва Л.В., Бойко Э.В. Опыт применения «Лютеин-форте» в лечении «сухой» формы возрастной макулярной дегенерации // Клин. офтальм. - 2007. - Т. 8, №2. - С. 72-75.][Кацнельсон Л.А., Лысенко В.С., Балишанская Т.И. Клинический атлас патологии глазного дна. - М.: Медицина, 1999. - 151 с.][Кацнельсон Л.А., Форофонова Т.И., Бунин А.Я. Сосудистые заболевания глаза. - М.: Медицина, 1990. - 270 с.][Киселёва Т.Н., Лагутина Ю.М., Кравчук Е.А. и др. Фезам в лечении неэкссудативных форм возрастной макулярной дегенерации // Клин. офтальм. - 2005. - Т. 6, №3. - С. 99-102.][Киселёва Т.Н., Лагутина Ю.М., Кравчук Е.А. Современные аспекты патогенеза, клиники и медикаментозного лечения неэкссудативных форм возрастной макулярной дегенерации // Клин. офтальм. - 2006. - Т. 7, №3. - С. 99-103.][Смолякова Г.П., Лысенко В.С. Патогенетические подходы к лечению возрастных ЦИХРД. Методические рекомендации. - Хабаровск, 2000. - 35 с.][Нащенкова О.В. Применение биологически активных веществ в лечении возрастной макулодистрофии // Клин. офтальм. - 2004. - Т. 5, №2. - С. 82-85.]