Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector210510.17816/KMJ2105Review ArticlePredictors of epileptic seizures - retrospective analysisKruchkovaM Vmaria.kruchkova@mail.ruPorunovA A-IsmagilovM F-GamirovaR G-Kazan National Scientific and Research Technical University, Kazan, RussiaKazan State Medical University, Kazan, RussiaKazan State Medical Academy, Kazan, Russia1512201293691391528032016Copyright © 2012, Kruchkova M.V., Porunov A.A., Ismagilov M.F., Gamirova R.G.2012The article surveys the data from domestic and international studies regarding the evolution of thoughts and contemporary point of view at epileptic seizure predictors, considering data from experimental and laboratory studies as well as from clinical studies. The provisional epileptic seizure predictors classification is proposed. The characteristics of the included predictors is given, the need for direct comparison considering results of laboratory studies on biological models as well as clinical trials on biologic objects is underlined.epileptic seizureepileptiform activityelectroencephalographypredictorsprognosisэпилептический приступэпилептиформная активностьэлектроэнцефалографияпредикторыпрогноз[Воробьёв В.И., Грибунин В.Г. Теория и практика вейвлет-преобразования. - СПб.: изд. Военного университета связи, 1999. - 204 с.][Меклер А.А. Применение аппарата нелинейного анализа динамических систем для обработки сигналов ЭЭГ. Актуальные проблемы современной математики: учёные записки / Под ред. Е.В. Калашникова. - СПб.: ЛГУ им. А.С. Пушкина, 2004. - Т. 13. - С. 112-140.][Чепурнов С.А., Аристов А.В., Бердиев Р.К. и др. Перспектива современных подходов к анализу ЭЭГ при эпилепсии с целью поиска предикторов приступов // Успехи физиол. наук. - 2010. - Т. 41, №4. - С. 27-44.][Baumgartner C., Serles W., Leutmezer F. et al. Preictal SPECT in temporal lobe epilepsy: regional cerebral blood flow is increased prior to electroencephalography-seizure onset // J. Nucl. Med. - 1998. - Vol. 39. - P. 978-982.][Federico P., Abbott D.F., Briellmann R.S. et al. Functional MRI of the pre-ictal state // Brain. - 2005. - Vol. 128. - P. 1811-1817.][Iasemidis L.D., Pardalos P., Sackellares J.C., Shiau D.S. Quadratic binary programming and dynamical system approach to determine the predictability of epileptic seizures // J. Comb. Optim. - 2001. - Vol. 5. - P. 9-26.][Lehnertz K., Elger C.E. Can epileptic seizures be predicted? Evidence from nonlinear time series analysis of brain electrical activity // Phys. Rev. Lett. - 1998. - Vol. 80. - P. 5019-5023.][Leutmezer F., Schernthaner С., Lurger S. et al. Electrocardiographic changes at the onset of epileptic seizure // Epilepsia. - 2003. - Vol. 44, N 3. - P. 348-354.][Litt B., Esteller R., Echauz J. et al. Epileptic seizures may begin hours in advance of clinical onset: a report of five patients // Neuron. - 2001. - Vol. 30. - P. 51-64.][Mormann F., Andrzejak R.G., Christian E.E. et al. Epileptic seizures are preceded by a decrease in synchronization // Epileps. Res. - 2003. - Vol. 53. - P. 173-185.][Mormann F., Andrzejak R.G., Elger C.E., Lehnertz K. Seizure prediction: the long and winding road // Brain. - 2007. - Vol. 130. - P. 314-333.][Novak V., Reeves L., Novak P. et al. Time-frequency mapping of RR-interval during complex partial seizures of temporal lobe origin // J. Auton. Nerv. Syst. - 1999. - Vol. 77. - P. 195-202.][Penfield W., Erickson T.C. Epilepsy and cerebral localization. - Springfield: Charles C. Thomas, 1941. - P. 101-103.][Schindler K., Wiest R., Kollar M., Donati F. EEG analysis with simulated neuronal cell models helps to detect pre-seizure changes // Clin. Neurophysiol. - 2002. - Vol. 113. - P. 604-614.]