Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector210310.17816/KMJ2103Research ArticleInfluence of the local anesthetics solutions’ temperature on muscular action potential amplitude decrease at brachial plexus blockSafinR Rsafin_r.r@hotmail.comAnisimovO G-Republican Clinical Hospital, Kazan, RussiaKazan State Medical Academy, Kazan, RussiaKazan State Medical University, Kazan, Russia1512201293690791028032016Copyright © 2012, Safin R.R., Anisimov O.G.2012Aim. To study influence of temperature of local anesthetics solutions on effectiveness of brachial plexus block using axillary access. Methods. Patients who underwent arm and hand surgeries were randomized either to the main group (n=25) or to the control group (n=25). In the main group, 1% lidocaine (20 ml) and 0.25% ropivacaine (40 ml - males, 30 ml - females) at 38 °C were used for brachial plexus block using axillary access. In the control group, anesthetics at room temperature were used. Brachial plexus block was performed using the axillary access at m. pectoralis major margin above the a. axillaris pulsation point. To register provoked muscular action potentials, a portative neurodiagnostic system «Nicolet One» was used. The percentage of provoked muscular action potential amplitude decrease was counted with results of a measurement before the block as a baseline. For additional analgesia and sedation phentanylum 0.005% was used until Ramsay sedation score II was achieved. «EZSAT-E» software package was used for data analysis. Results. In the main group brachial plexus block was achieved 14.2±3.4 minutes earlier than in the control group. Phentanylum dose required to provide psychic and emotional comfort was 45.4% lower in the main group (3.0±0.9 μg/kg per hour) compared to the control group (5.5±1.7 μg/kg per hour). Conclusion. The use of local anesthetics solutions at body temperature increases the efficiency of brachial plexus block and reduces the time of it’s achievement, increases it’s analgesic potential and decreases the need for narcotic analgesics to provide psychic and emotional comfort for the patient.brachial plexus blocklocal anestheticsdrug temperatureelectromyographyаксиллярный блок плечевого сплетениясредства для местной анестезиитемпература лекарственного средстваэлектромиография[Кормачёв М.В., Сафин Р.Р., Юнусова И.И. и др. Влияние температуры на физико-химические и клинико-фармакологические свойства растворов местных анестетиков // Казан. мед. ж. - 2010. - №6. - С. 818-821.][Лахин Р.Е., Сафин Р.Р., Бокатюк С.В. Роль температурного фактора в изменении физико-химических свойств местных анестетиков // Вестн. анестезиол. и реаниматол. - 2011. - Т. 8, №1. - С. 36-40.][Сафин Р.Р. Способ проводниковой анестезии. Патент РФ на изобретение №2440152 // Бюлл. изобр. и полезн. моделей. - 2012. - №2. - С. 131.][Barash P.G., Cullen B.F., Stoelting R.T. Clinical anesthesia. - Philadelphia: Lippicont, 1989. - 1575 p.][Kamaya H., Hayes J., Ueda I. Dissotiaton constants of local anesthetics and their temperature dependence // Anesth. Analg. - 1983. - Vol. 62. - P. 1025-1030.][O’Donnell B.D., Iohom G. Conclusion: an estimation of the minimum effective anesthetic volume of 2% lidocaine in ultrasound-guided axillary brachial plexus block perioperative medicine // Perioperat. Med. - 2009. - Vol. 111, N 1. - P. 25-29.][Vester-Andersen T., Christiansen C., Sørensen M. еt al. Perivascular axillary block II: influence of injected volume of local anaesthetic on neural blockade // Acta. Anaesthesiol. Scand. - 1983. - Vol. 27, N 2. - P. 95-98.]