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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1958</article-id><article-id pub-id-type="doi">10.17816/KMJ1958</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Organ-saving treatment of invasive bladder cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Органосохраняющее лечение инвазивного рака мочевого пузыря</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sitdykova</surname><given-names>M E</given-names></name><name xml:lang="ru"><surname>Ситдыкова</surname><given-names>Марина Эдуардовна</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zubkov</surname><given-names>A Y</given-names></name><name xml:lang="ru"><surname>Зубков</surname><given-names>Алексей Юрьевич</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nuriev</surname><given-names>I R</given-names></name><name xml:lang="ru"><surname>Нуриев</surname><given-names>Ильяс Рустамович</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan State Medical University, Kazan, Russia</institution></aff><aff><institution xml:lang="ru">Казанский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2013</year></pub-date><volume>94</volume><issue>4</issue><issue-title xml:lang="en">VOL 94, NO4 (2013)</issue-title><issue-title xml:lang="ru">ТОМ 94, №4 (2013)</issue-title><fpage>501</fpage><lpage>505</lpage><history><date date-type="received" iso-8601-date="2016-03-28"><day>28</day><month>03</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Sitdykova M.E., Zubkov A.Y., Nuriev I.R.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Ситдыкова М.Э., Зубков А.Ю., Нуриев И.Р.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Sitdykova M.E., Zubkov A.Y., Nuriev I.R.</copyright-holder><copyright-holder xml:lang="ru">Ситдыкова М.Э., Зубков А.Ю., Нуриев И.Р.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/1958">https://kazanmedjournal.ru/kazanmedj/article/view/1958</self-uri><abstract xml:lang="en"><p>The review describes the modern approaches to open and endoscopic surgery, chemo- and radiotherapy in organ-saving treatment of invasive bladder cancer. Bladder cancer nowadays ranks the second among urological malignancies. Incidence of bladder cancer in Russia has increased by 58.6% over the past 10 years, with the share of invasive tumors reaching 30%. According to the European Association of Urology guidelines, the radical cystectomy with ureterocolonic diversion is the standard treatment of muscle-invasive bladder cancer. However, the extensive surgical trauma, comorbidities and exhaustion of patients, disability and social adaptation failure as well as the high mortality rate restrict the use of cystectomy. Thereby, taking into account the dynamic development of chemo- and radiotherapy allowing to reduce the recurrence rate, more and more experts are inclined to use organ-saving treatment of invasive bladder cancer. Organ-saving treatment has several advantages: it is less complicated and costly, preserves sexual function, decreases the risk of kidney damage and provides a good quality of life. Still, scanty publications are comparing results of cystectomy and organ-saving treatments of invasive bladder cancer, causing controversial opinions and highlighting the need for further studies.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен обзор литературы, посвящённый открытой и эндоскопической хирургии, применению химио- и лучевой терапии в органосохраняющем лечении инвазивного рака мочевого пузыря. В настоящее время рак мочевого пузыря занимает второе место среди онкоурологических заболеваний. За последние 10 лет прирост больных данной нозологии в России составил 58,6%. На долю инвазивной формы приходится до 30% новообразований. Согласно рекомендациям Европейской ассоциации урологов, стандартным методом лечения мышечно-инвазивного рака мочевого пузыря считают радикальную цистэктомию с деривацией мочи в сегмент кишечного тракта. Однако большой объём и травматичность операции, отягощённость и истощённость пациентов, инвалидизация и социальная дезадаптация, а также высокий процент летальности ограничивают применение цистэктомии. В связи с этим, а также с динамичным развитием химиолучевой терапии, которая позволяет снизить частоту рецидивов, всё больше специалистов склоняются к возможности органосохраняющего лечения инвазивного рака мочевого пузыря. Органосохраняющее лечение имеет ряд преимуществ: отсутствие громоздкости в проведении хирургического вмешательства, снижение материальных затрат, сохраняется половая функция, уменьшается опасность нарушения функций почек, обеспечивается хорошее качество жизни. Таким образом, в литературе существуют немногочисленные публикации и разноречивые мнения по вопросу сравнительной оценки результатов цистэктомии и органосохраняющих операций при инвазивном раке мочевого пузыря, что обосновывает необходимость дальнейшего изучения данной проблемы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>bladder cancer</kwd><kwd>invasive bladder cancer</kwd><kwd>organ-saving treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак мочевого пузыря</kwd><kwd>инвазивная форма</kwd><kwd>органосохраняющее лечение</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Аполихин О.И., Какорина Е.П., Сивков А.В. и др. Состояние урологической заболеваемости в Российской Федерации по данным официальной статистики // Урология. - 2008. - №3. - С. 3-9.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Болотина Л.В., Русаков И.Г. 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