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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Kazan medical journal</journal-id><journal-title-group><journal-title xml:lang="en">Kazan medical journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Казанский медицинский журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0368-4814</issn><issn publication-format="electronic">2587-9359</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1946</article-id><article-id pub-id-type="doi">10.17816/KMJ1946</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Theoretical and clinical medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Теоретическая и клиническая медицина</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Depression in young HIV-positive patients is associated with anemia</article-title><trans-title-group xml:lang="ru"><trans-title>Депрессия у молодых ВИЧ-инфицированных пациентов связана с анемией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khasanova</surname><given-names>G R</given-names></name><name xml:lang="ru"><surname>Хасанова</surname><given-names>Гульшат Рашатовна</given-names></name></name-alternatives><email>gulshatra@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bikkinina</surname><given-names>O I</given-names></name><name xml:lang="ru"><surname>Биккинина</surname><given-names>Олеся Ильмировна</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Anokhin</surname><given-names>V A</given-names></name><name xml:lang="ru"><surname>Анохин</surname><given-names>Владимир Алексеевич</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan State Medical University, Kazan, Russia</institution></aff><aff><institution xml:lang="ru">Казанский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Republican Centre for AIDS and Infectious Diseases Treatment and Prevention, Kazan, Russia</institution></aff><aff><institution xml:lang="ru">Республиканский центр по борьбе со СПИД и инфекционными заболеваниями, г. Казань</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2013</year></pub-date><volume>94</volume><issue>4</issue><issue-title xml:lang="en">VOL 94, NO4 (2013)</issue-title><issue-title xml:lang="ru">ТОМ 94, №4 (2013)</issue-title><fpage>445</fpage><lpage>450</lpage><history><date date-type="received" iso-8601-date="2016-03-28"><day>28</day><month>03</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Khasanova G.R., Bikkinina O.I., Anokhin V.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Хасанова Г.Р., Биккинина О.И., Анохин В.А.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Khasanova G.R., Bikkinina O.I., Anokhin V.A.</copyright-holder><copyright-holder xml:lang="ru">Хасанова Г.Р., Биккинина О.И., Анохин В.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://kazanmedjournal.ru/kazanmedj/article/view/1946">https://kazanmedjournal.ru/kazanmedj/article/view/1946</self-uri><abstract xml:lang="en"><p>Aim. To examine the interrelation between depression and anemia in HIV-positive patients. Methods. A cross-sectional study included 99 HIV-positive patients. Anemia was defined as hemoglobin concentration below 12 g/dL in women and 13 g/dL in men. Depressive symptoms were measured using the Beck Hopelessness Scale. Results. Anemia was registered in 30.3% of patients. In 54.5% of patients depression was detected (Beck Scale score ≥10). In patients with anemia the prevalence of depression was 76.7% including severe depression in 20% of patients. Mean Beck Scale score in anemia group was significantly higher compared to the group without anemia (17.57±12.90%, 95% confidence interval 13.5-20.5 and 10.06±8.07, 95% confidence interval 7.7-12.3, t=3.2, p=0.007 relevantly). Moderate reverse correlation between Beck scale scores and hemoglobin level was revealed ((r=-0.24, p=0.019). After stratification and adjusting for potential confounders, anemia was found to be associated with higher prevalence of depression in patients younger than 40 years old. The prevalence ratio for depression in patients with anemia, comparing to patients without anemia was 1.827 (95% confidence interval 1.28-2.61, λ2=8.85, p=0.0029) in this age group. Detected association did not depend on sex, family status, disease duration, CD4-level and treatment with antiretrovirals. Conclusion. Depressive symptoms are associated with anemia in HIV-patients younger than 40 years old.</p></abstract><trans-abstract xml:lang="ru"><p>Цель. Оценка взаимосвязи анемии и депрессии у больных, инфицированных вирусом иммунодефицита человека (ВИЧ). Методы. Проведено поперечное срезовое исследование группы из 99 пациентов. Анемию определяли как снижение концентрации гемоглобина ниже 120 г/л у женщин и 130 г/л у мужчин. Для оценки наличия и выраженности депрессии использовали шкалу Бека. Результаты. Анемия была диагностирована у 30,3% пациентов. У 54,5% больных с ВИЧ-инфекцией выявлены баллы, соответствующие депрессии (≥10). В подгруппе больных с анемией частота депрессии составила 76,7%, в том числе у 20% пациентов с анемией получены результаты анкетирования, соответствующие тяжёлой депрессии. Среднегрупповой суммарный балл по шкале Бека в группе больных с анемией статистически значимо превышал таковой в группе без анемии (17,57±12,90%, 95% доверительный интервал 13,5-20,5 и 10,06±8,07, 95% доверительный интервал 7,7-12,3 соответственно, t=3,2, p=0,007). Установлена обратная корреляционная связь средней силы между тяжестью депрессии и уровнем гемоглобина (r=-0,24, p=0,019). После стратификации и взвешивания по потенциальным конфаундерам была установлена связь между наличием анемии и депрессии у пациентов моложе 40 лет. В данной возрастной группе отношение превалентностей депрессии при сравнении групп пациентов с анемией и без неё составило 1,827 (95% доверительный интервал 1,28-2,61, λ2=8,85, p=0,0029). Выявленная связь не зависела от пола, семейного статуса, стажа инфекции, уровня CD4-клеток, антиретровирусной терапии. Вывод. Симптомы депрессии ассоциированы с анемией у ВИЧ-инфицированных пациентов моложе 40 лет.</p></trans-abstract><kwd-group xml:lang="en"><kwd>HIV-infection</kwd><kwd>anemia</kwd><kwd>depression</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ВИЧ-инфекция</kwd><kwd>анемия</kwd><kwd>депрессия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Хасанова Г.Р. Анемия хронического заболевания и ВИЧ-инфекция // Практ. мед. - 2012. - №1. - С. 49-51.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Beck А.Т., Ward C.H., Mendelson M. et al. An inventory for measuring depression // Arch. Gen. Psych. - 1961. - Vol. 4. - P. 44-46.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bromet E., Andrade L.H., Hwang I. et al. Cross-national epidemiology of DSM-IV major depressive episode // BMC. Medicine, 2011. - doi:10.1186/1741-7015-9-90. - http://www.biomedcentral.com/content/pdf/1741-7015-9-90.pdf (дата обращения: 10.06.13).</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Chandra P.S., Desai G., Ranjan S. HIV and psychiatric disorders // Ind. J. Med. Res. - 2005. - Vol. 121. - P. 451-467.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Cook J.A., Grey D., Burke J. et al. Depressive symptoms and AIDS-related among a multisite cohort of HIV-positive women // Am. J. Public Health. - 2004. - Vol. 94. - P. 1133-1140.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>De Maeyer E.M., Dallman P., Gurney J.M. et al. Preventing and controlling iron deficiency anaemia through primary health care. A guide for health administrators and programme managers. - Geneva: World Health Organization, 1989. - 58 p.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Farinpour R., Miller E.N., Satz P. et al. Psychosocial risk factors of HIV morbidity and mortality: findings from the Multicenter AIDS Cohort Study (MACS) // J. Clin. Exp. Neuropsychol. - 2003. - Vol. 25. - P. 654-670.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Horberg M.A., Silverberg M., Hurley L. et al. Effects of depression and selective serotonin reuptake inhibitor use on adherence to highly active antiretroviral therapy and on clinical outcomes in HIV-infected patients // J. Acquir. Immune Defic. Synd. - 2008. - Vol. 47. - P. 384-390.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Komiti A., Judd F., Grech P. et al. Depression in people living with HIV/AIDS attending primary care and outpatient clinics // Aust. N. Z. J. Psychiatry. - 2003. - Vol. 37. - P. 70-77.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Levine A.M., Berehane K., Karim R. et al. Impact of highly active antiretroviral therapy on anemia and relationship between anemia and survival in a large cohort of HIV-infected women: women’s interagency HIV study // J. Acquir. Immune Defic. Syndr. - 2004. - Vol. 37, N 2. - P. 1245-1252.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Marwick K.F., Kaaya S.F. Prevalence of depression and anxiety disorders in HIV-positive outpatients in rural Tanzania // AIDS Care. - 2010. - Vol. 22, N 4. - P. 415-419.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Michael D.S., David A.S., Debra S.H. et al. Depression severity and drug injection HIV risk behavior // Am. J. Psychiatry. - 2003. - Vol. 160. - P. 1659-1662.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Onder G., Penninx B.W., Cesari M. et al. Anemia is associated with depression in older adults: results from the InCHIANTI study // J. Gerontol. Biol. Sci. Med. Sci. - 2005. - Vol. 60, N 9. - P. 1168-1172.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Steptoe A., Wikman A., Molloy G.J., Kaski J.-C. Anaemia and the development of depressive symptoms following acute coronary syndrome: longitudinal clinical observational study // BMJ. Open. - 2012. - Vol. 2, N 1. - P. 551.</mixed-citation></ref></ref-list></back></article>
