Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector191210.17816/KMJ1912Research ArticleDiagnostic value of vascular endothelial growth factor determination in chronic pyelonephritis in childrenBazarnyV Vvlad-bazarny@yandex.ruAverchenkoM V-Ural State Medical Academy, Ekaterinburg, Russia1510201394565665828032016Copyright © 2013, Bazarny V.V., Averchenko M.V.2013Aim. This paper is devoted to the evaluation of clinical and diagnostic value of vascular endothelial growth factor detection in chronic pyelonephritis in children. Methods. The study included 62 patients with different compensation degrees of the disease. Patients were divided into 2 groups - subcompensation (37 patients), and decompensation (25 patients). Renal function was assessed by glomerular filtration rate. Vascular endothelial growth factor concentration was determined by the enzyme-linked immunosorbent assay. To assess the renal vasculature, triplex ultrasonography using pulsed Doppler was performed. The endothelial dysfunction was examined by postocclusion test with reactive hyperemia. Results. Vascular endothelial growth factor level had been significantly increasing in patients according to the severity of the disease. The vascular endothelial growth factor concentration exceeded 600 pg/ml all patients who has later developed chronic renal failure. The sensitivity of this indicator at the abovementioned critical point was assessed as 80%. The change of resistance index reflected renal vascularization disorders. The endothelial dysfunction in postocclusion test was also revealed in patients with pyelonephritis. The vascular endothelial growth factor level highly correlated with the glomerular filtration rate and resistance index. Conclusion. Detecting the vascular endothelial growth factor serum level is one of the tools for endothelial dysfunction laboratory monitoring and renal function assessment in in children with chronic pyelonephritis.chronic pyelonephritischildrenvascular endothelial growth factorхронический пиелонефритдетифактор роста эндотелия сосудов[Герасимов А.Н. Медицинская статистика. - М.: МИА, 2007. - 480 с.][Детская нефрология. Практическое руководство / Под ред. Э. Лойманна, А.Н. Цыгина, А.А. Саркисяна. - М.: Литтерра, 2010. - 390 с.][Belting M., Almgren P., Manjer J. et al. Vasoactive peptides with angiogenesis-regulating activity predict cancer risk in males // Cancer Epidemiol. Biomarkers Prev. - 2012. - Vol. 21, N 3. - P. 513-522.][Celermajer D.S. Testing endothelial function using ultrasound // J. Cardiovasc. Pharmacol. - 1998. - Vol. 32, Suppl. 3. - Р. 29-32.][Dei Cas A., Gnudi L. VEGF and angiopoietins in diabetic glomerulopathy: how far for a new treatment? // Metabolism. - 2012. - Vol. 61,N 12. - P. 1666-1673.][Eichmann A., Simons M. VEGF signaling inside vascular endothelial cells and beyond // Curr. Opin. Cell Biol. - 2012. - Vol. 24,N 2. - P. 188-193.][Lee H.S. Paracrine role for TGF-b-induced CTGF and VEGF in mesangial matrix expansion in progressive glomerular disease // Histol. Histopathol. - 2012. - Vol. 27, N 9. - P. 1131-1141.][Obeidat M., Ballermann B.J. Glomerular endothelium: a porous sieve and formidable barrier // Exp. Cell Res. - 2012. - Vol. 318,N 9. - Р. 964-972.][Simons M. An inside view: VEGF receptor trafficking and signaling // Physiology (Bethesda). - 2012. - Vol. 27, N 4. - Р. 213-222.][Splendiani G., Parolini C., Fortunato L. Resistive index in chronic nephropathies: predictive value of renal outcome // Clin. Nephrol. - 2002. - Vol. 57. - P. 45-50.]