Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector176510.17816/KMJ1765Research ArticleThe clinical diagnosis of HIV-infection in a specialized hospitalFazylovV H-ManapovaE Relveram@yandex.ruGoltzM L-LustikmanE M-BeshimovA T-Kazan State Medical University, Kazan, RussiaRepublican Clinical Hospital of Infectious Diseases, Kazan, RussiaRepublican Centre for AIDS and Infectious Diseases Treating and Prevention, Kazan, Russia15022013941303428032016Copyright © 2013, Fazylov V.H., Manapova E.R., Goltz M.L., Lustikman E.M., Beshimov A.T.2013Aim. To assess the structure of opportunistic infections and concomitant diseases, including the stage of infection, in patients hospitalized with HIV-infection. Methods. 40 cases of in-patient treatment of patients diagnosed with HIV aged 25 to 42 (mean age 34.26±1.22), male - 26, female - 14, with mean duration of infection 6,7±0,6 years were analyzed. Results. The patients were admitted to the hospital on 17±3.24 day of the disease, including cases of pulmonary diseases (on 23±3.6 day), cases of chronic hepatitis reactivation and liver cirrhosis decompensation (on 30±10.09 day), cases of acute infections (on 7±1.16 day). Previous psychoactive drug use was confirmed in 28 (70.0%) of patients. 13 (32.5%) patients received treatment with antiretroviral drugs, 3 (7.5%) have abandoned it, the rest had never been offered an antiretroviral treatment. According to the classification by V.I. Pokrovsky, the patient were staged as: stage III - 4 (10.0%) patients, stage IVA - 8 (20.0%), IVB - 11 (27.5)%, IVC - 17 (42.5%) patients. Pulmonary diseases were the most prevalent and were diagnosed in 17 (42,5%) patients, including cases of community-acquired pneumonia (focal, multisegmental, interstitial, lobular) in 8 (47.1%) patients, pulmonary tuberculosis (infiltrative, military, intrathoracic lymph nodes tuberculosis) in 9 (52.9)% patients. Liver diseases (chronic hepatitis B, chronic hepatitis B + C, liver cirrhosis) were the most frequent concomitant diseases and were found in 21 (52.5%) patients. Conclusion. Herpes zoster and liver diseases are the most predominant concomitant diseases at the early stages of HIV-infection, whereas ooportunistic infections, tuberculosis, community-acquired pneumonia and sepsis are typical in patients with late stages of HIV-infection.HIVopportunistic diseasesantiretroviralsRepublic of TatarstanВИЧ-инфекцияоппортунистические заболеванияантиретровирусная терапияРеспублика Татарстан[Ермак Т.Н., Перегудова А.Б., Груздев Б.М. Оппортунистические инфекции у ВИЧ-инфицированных: чудес не бывает // Тер. арх. - 2006. - №11. - С. 80-81.][Покровский В.В., Ладная Н.Н., Соколова Е.В., Буравцова Е.В. ВИЧ-инфекция: информ. бюл. №27 ФНМЦ ПБ СПИД. - М., 2005. - 27 с.][Покровский В.В., Юрин О.Г., Кравченко А.В. и др. Протоколы лечения больных ВИЧ-инфекцией // Эпидемиол. и инфекц. бол. Актуал. вопр. (приложение). - 2011. - №3. - 43 с.][Шахгильдян В.И. Цитомегаловирусная пневмония. В кн.: Пневмония / Под ред. А.Г. Чучалина, А.И. Синопальникова, Л.С. Страчунского. - М.: МИА, 2006. - С. 360-385.][Gardner E.M., McLees M.P., Steiner J.F. et al. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection // Clin. Infect. Dis. - 2011. - Vol. 52. - P. 793-800.][Sherman K.E., Rouster S.D., Chung R.T., Rajicic N. Hepatitis C virus prevalence among patients co-infected with human immunodeficiency virus: a cross-sectional analysis of the U.S. Adult AIDS Clinical Trials Group // Clin. Infect. Dis. - 2002, Mar. 15. - N 34. - Р. 831-837.][Wit F.W., Weverling G.J., Weel J. et al. Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy // J. Infect. Dis. - 2002. - Vol. 186. - P. 23-31.][Weber R., Sabin C.A., Friis-Møller N. et al. Liver-related deaths in persons infected with the human immunodeficiency virus // Arch. Intern. Med. - 2006. - Vol. 166, N 15. - P. 1632-1641.]