Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector161410.17750/KMJ2015-923Research ArticleDiagnosis and specific prevention of hepatitis b in a specialized settingEremeevaZh Gfin5zhannik@rambler.ruMinullinI Kfin5zhannik@rambler.ruPlatonovaO Vfin5zhannik@rambler.ruBogdanovaE Vfin5zhannik@rambler.ruFazylovV Khfin5zhannik@rambler.ruKazan State Medical University, Kazan, RussiaRepublican clinical dispensary of dermatology and sexually transmitted diseases, Kazan, Russia1512201596692392928032016Copyright © 2015, Eremeeva Z.G., Minullin I.K., Platonova O.V., Bogdanova E.V., Fazylov V.K.2015<p><strong>Aim.</strong> To evaluate the diagnostic approaches to viral hepatitis B and immune response on hepatitis B vaccination among clinical dispensary of dermatology and sexually transmitted diseases medical staff.</p>
<p><strong>Methods.</strong> The study included 92 serum samples of healthcare facility staff who underwent hepatitis B vaccination more than 7 years before. To assess the post-vaccination immunity, levels of antibodies to surface antigen of hepatitis B (anti-HBS) were determined by ELISA. Published data on the duration of post-vaccination immunity and annual reporting forms of clinical dispensary of dermatology and sexually transmitted diseases of Kazan in 2013 were analyzed.</p>
<p><strong>Results.</strong> Patients with human immunodeficiency virus, viral hepatitis B and C are often seeking for medical aid, retaining the risk for medical staff and other patients to be infected. Diagnosis of hepatitis B virus in medical settings is based on the detection of hepatitis B surface antigen (HBSAg), while revealing hepatitis B core antigen (HBCAg), anti-HBC (summary levels), extra-Dane particle antigen (HBEAg) and other markers of viral hepatitis B would allow to diagnose a latent form of hepatitis B. In 56.5% (n=92) of cases, anti-HBs levels were below the protective titer, suggesting higher risk for infection and requiring an additional revaccination. In the remaining 43.5% of cases, protective antibodies titers were revealed, confirming the effectiveness of specific prevention measures.</p>
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