Kazan medical journalKazan medical journal0368-48142587-9359Eco-Vector157110.17816/KMJ1571Research ArticleEpidemiology of post-traumatic epilepsy in the Republic of TatarstanYarmukhametovaM Rjmr-2010@mail.ruKazan State Medical University, Kazan, Russia1508201293467768028032016Copyright © 2012, Yarmukhametova M.R.2012Aim. To conduct a comprehensive study of epidemiological and clinical characteristics of patients with post-traumatic epilepsy among the adult population of three districts of the Republic of Tatarstan. Methods. The study was conducted in 2009 in three districts: Arskiy, and Baltasinskiy Tetyushskiy. Cases of active epilepsy were recorded according to the results of household walkovers, continuous investigation of medical outpatient records in healthcare institutions, registration cards of the calls of the ambulance station. Clinical and neurological examinations, including examination of a neurologist, EEG, and in addition - magnetic resonance and computed tomography were performed in cases of newly diagnosed epilepsy, as well as to confirm the diagnosis. Results. Of the established causes of symptomatic epilepsy the most common one was traumatic brain injury (25.09%), notably in males (n=52, 19.47%) on average three times more frequently than in females (n=15, 5.61%). Most commonly the injuries were seen in the age group 30-49 years (5-6 times more common in men). In 23.88% (n=16) of patients with post-traumatic epilepsy more than 12 attacks per year were registered, in 73,14% (n=49) - 1-12 attacks per year, 2.98% (n=2) patients were in medical remission. 83.58% of patients received monotherapy. The most commonly prescribed medications - valproic acid salt, carbamazepine, topiramate, both as monotherapy and as part of polytherapy. Conclusion. A high prevalence of post-traumatic epilepsy (25.09%) was revealed; an insufficient degree of control of epileptic seizures was noted, which was often due to irrational drug therapy.neurologyepilepsyhead traumaepidemiologyincidenceprevalenceRepublic of Tatarstanневрологияэпилепсиячерепно-мозговая травмаэпидемиологиязаболеваемостьраспространённостьРеспублика Татарстан[Белова Е.В. Клинико-эпидемиологический анализ эпилепсии и фармако-экономическое обоснование помощи взрослому населению в городе Тюмени. - М., 2004. - 145 с.][Беляев О.В. Эпидемиология и реабилитация больных эпилепсией (по материалам Волгоградской области). - СПб., 2005. - 140 с.][Бирюкбаева Г.Н., Мильчакова Л.Е., Кривошапкин В.Г. и др. Эпидемиология эпилепсии в сельской местности Республики Саха-Якутия // Ж. неврол. и психиатр. им. С.С. Корсакова. - 2008. - №3. - С. 67-70.][Гехт А.Б., Мильчакова Л.Е., Чурилин Ю.Ю. и др. Эпидемиология эпилепсии в России // Ж. неврол. и психиатр. им. С.С. Корсакова. - 2006. - Т. 106. - С. 3-7.][Мильчакова Л.Е. Эпилепсия в отдельных субъектах Российской Федерации: эпидемиология, клиника, социальные аспекты, возможности оптимизации фармакотерапии. - М., 2008. - 189 с.][Стародумов А.А. Клинико-эпидемиологическое и медико-психологическое исследование эпилепсии в среднепромышленном городе (В связи с задачами совершенствования противоэпилептологической службы). - СПб., 1999. - 158 с.][Статистика здоровья населения и здравоохранения (по материалам Республики Татарстан за 2005-2009 годы). - Казань, 2010. - С. 48-51.][Тойтман Л.Л. , Тойтман О.Л. Клинико-эпидемиологическая характеристика эпилепсии в Еврейской автономной области // Ж. неврол. и психиатр. им. С.С. Корсакова. - 2000. - №9. - С. 45-47.][Ярмухаметова М.Р., Богданов Э.И., Мильчакова Л.Е., Гехт А.Б. Эпидемиология эпилепсии у взрослых в Республике Татарстан // Неврол. вестн. - 2010. - Т. XLII, №4. - С. 3-8.][Boyle P., Parkin D.M. Statistical methods for registries / In: Cancer registration: principles and methods. - IARC Scientific Publications No. 95. - International Agency for Research on Cancer, Lyon, France, 1991. - 296 p.][D’Ambrosio R., Perucca E. Epilepsy after head injury // Curr. Opin. Neurol. - 2004. - Vol. 17, N 6 - P. 731-735.][Forsgren L., Beghi E., Oun A., Sillanpa M. The epidemiology of epilepsy in Europe - a systematic review // Eur. J. Neuro. - 2005. - N 12. - P. 245-253.][ICE, 1989: Commission on classification and terminology of ILAE. Proposal for revised classification of epilepsies and epileptic syndromes // Epilepsia. - 1989. - Vol. 30. - P. 389-399.][ICES, 1981: Commission on classification and terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures // Epilepsia. - 1981. - Vol. 22. - P. 489-501.][Olafsson E., Hauser A. Prevelence of epilepsy in rural iceland: a population-based study // Epilepsia. - 1999. - Vol. 40, N 11. - P. 1529-1534.][Velez A., Eslava-Cobos J. Epilepsy in Colombia: epidemiologic profile and classification of epileptic seizures and syndromes // Epilepsia. - 2006. - Vol. 47, N 1. - P. 193-201.]